Postnatal Cytomegalovirus Infection Through Human Milk in Preterm Infants

Hamprecht, Klaus; Goelz, Rangmar

doi:10.1016/j.clp.2016.11.012

Cited by 97 publications

(130 citation statements)

References 55 publications

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“…Previous research using macaques with hippocampal lesions made in the neonatal period demonstrated schizophrenic-like characteristics that only manifested during adolescence (86). Further, studies of postnatally acquired CMV revealed that some of the cognitive sequelae do not become evident until school age (22). Our finding that postnatal ZIKV infection of infant RMs causes persistent changes consistent with delayed or dysfunctional brain maturation suggest that long-term clinical monitoring of all ZIKV-infected infants and children may be critical.…”

Section: Discussionmentioning

confidence: 99%

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Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

et al. 2018

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The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid- and neuro-tropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration. Structural and resting state functional Magnetic Resonance Imaging (MRI/rs-fMRI) show persistent enlargement of lateral ventricles, maturational changes in specific brain regions, and altered functional connectivity (FC) between brain areas involved in emotional behavior and arousal functions, including weakened amygdala-hippocampal connectivity in two out of two ZIKV-infected infant RMs several months after clearance of ZIKV RNA from peripheral blood. ZIKV infection also results in distinct alterations in the species-typical emotional reactivity to acute stress, which were predicted by the weak amygdala-hippocampal FC. We demonstrate that postnatal ZIKV infection of infants in this model impacts neurodevelopment, suggesting that long-term clinical monitoring of pediatric cases is warranted.

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Section: Discussionmentioning

confidence: 99%

“…These infections are transmitted in utero but also postnatally via breastfeeding and can lead to significant long-term neurologic complications, such as encephalopathy and cognitive impairment (20-22). The route of postnatal transmission of ZIKV differs from CMV and HIV (arthropod vs. breast milk).…”

Section: Introductionmentioning

confidence: 99%

Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

et al. 2018

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“…Цитомегаловирус в грудном молоке имеют около 20% серопозитивных матерей и 30-60% их детей оказыва-ются инфицированными [4]. Реактивация цитомега-ловируса в молочных железах наиболее часто насту-пает между 2-й и 12-й неделей жизни младенца, т.е.…”

Section: обзоры литературыunclassified

On the Possibilities of Laboratory Verification of Cytomegalovirus Infection in Children

Пермякова¹,

Lvova²,

Pospelova³

2017

Ross. vestn. perinatol. pediatr.

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“…A BM‐acquired CMV infection usually causes no clinical symptoms in healthy neonates and has a low probability of causing deafness and nervous system sequela. However, the risk of serious sequela from CMV may increase in pathologically jaundiced infants . BM‐acquired CMV infection in pathologically jaundiced infants is seldom reported, and there are no reported data concerning local populations.…”

Section: Introductionmentioning

confidence: 99%

“…However, the risk of serious sequela from CMV may increase in pathologically jaundiced infants. 12,13 BM-acquired CMV infection in pathologically jaundiced infants is seldom reported, and there are no reported data concerning local populations. CMV screening and diagnostic methods should be comprehensively assessed to facilitate selecting a suitable test method.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of breastmilk‐acquired cytomegalovirus infection in jaundiced infants

Hou¹,

Liu²,

Fan³

et al. 2020

Clinical Laboratory Analysis

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Background Our objective was to evaluate the prevalence and different diagnostic methods of breastmilk (BM)‐acquired cytomegalovirus (CMV) infection in a pathologically jaundiced cohort. Methods A total of 400 infants confirmed with pathological jaundice at The People's Hospital of Qingyang City were screened for BM‐acquired CMV infection between February 2018 and February 2019. A total of 300 infants were finally enrolled in our study. CMV infection was confirmed by detecting both CMV‐DNA in various samples using FQ‐PCR and CMV‐IgM with chemiluminescence. Clinical and other laboratory data were collected from these infants during their hospitalization or regular visits. Results Ninety‐eight (32.67%) subjects were confirmed to be BM CMV‐DNA–positive, and 18 (18.37%) were diagnosed with a BM‐acquired CMV infection. All 18 (100%) infants with a BM‐acquired CMV infection were CMV‐DNA–positive in urine, while 5 (27.78%) cases and 11 (61.11%) cases were confirmed in plasma and peripheral blood mononuclear cells (PBMCs), respectively. Only 6 (33.33%) infants were CMV‐IgM–positive. Birthweight, direct bilirubin, aspartate aminotransferase, and the viral load in BM of the BM‐acquired CMV group were higher than those in the non‐infected group (P < .05). Low birthweight and viral load in BM were risk factors for BM‐acquired CMV infection. Detecting CMV‐DNA in urine samples exhibited better performance than the other methods for screening BM‐acquired CMV infections. Conclusions Our study found a high prevalence of BM‐acquired CMV infection in jaundiced infants, and detecting CMV‐DNA in a urine sample was the most sensitive method for disease screening.

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Postnatal Cytomegalovirus Infection Through Human Milk in Preterm Infants

Cited by 97 publications

References 55 publications

Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

On the Possibilities of Laboratory Verification of Cytomegalovirus Infection in Children

High prevalence of breastmilk‐acquired cytomegalovirus infection in jaundiced infants

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