Postnatal development of myenteric neurochemical phenotype and impact on neuromuscular transmission in the rat colon

Vries, P. De; Soret, Rodolphe; Suply, E.; Héloury, Yves; Neunlist, Michel

doi:10.1152/ajpgi.00092.2010

Cited by 56 publications

(69 citation statements)

References 28 publications

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“…Remarkably, enteric neuron subtype plasticity appears to continue after birth, at least in rodents, in which close proximity of the developing ENS to bowel lumen facilitates diet and intestinal microbe-induced changes in neuronal cell fate (102). In rats, the percentage of ChAT-IR neurons in colon myenteric plexus increases from P14 to P36, whereas the percentage of nNOS-IR neurons increases from P1 to P5 and then remains unchanged to P36 (103). These ratios can be altered by intraluminal lipids.…”

Section: Ens Morphogenesis Does Not End When Encdcs Reach "The End"mentioning

confidence: 99%

Building a second brain in the bowel

Avetisyan¹,

Schill²,

Heuckeroth³

2015

J. Clin. Invest.

116

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Section: Ens Morphogenesis Does Not End When Encdcs Reach "The End"mentioning

confidence: 99%

Building a second brain in the bowel

Avetisyan¹,

Schill²,

Heuckeroth³

2015

J. Clin. Invest.

116

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“…During later postnatal development, the intestinal epithelial barrier surface increases, and the paracellular permeability per surface of the intestinal epithelial barrier decreases (13,27). In rats, the proportion of myenteric neurons in the colon increases during the first weeks of the postnatal period, which is likely related to the development of colonic spontaneous motility (31). During the suckling and weaning periods, the composition of the diet and the amount of dietary input modulate structural and functional development of the intestine due to a direct effect on genes that determine this structural and functional development (2).…”

mentioning

confidence: 99%

Development and entrainment of the colonic circadian clock during ontogenesis

Polidarová

Olejníková

Paušlyová

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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-Colonic morphology and function change significantly during ontogenesis. In mammals, many colonic physiological functions are temporally controlled by the circadian clock in the colon, which is entrained by the central circadian clock in the suprachiasmatic nuclei (SCN). The aim of this present study was to ascertain when and how the circadian clock in the colon develops during the perinatal period and whether maternal cues and/or the developing pup SCN may influence the ontogenesis of the colonic clock. Daily profiles of clock genes Per1, Per2, Cry1, Cry2, Reverb␣, Bmal1, and Clock expression in the colon underwent significant modifications since embryonic day 20 (E20) through postnatal days (P) 2, 10, 20, and 30 via changes in the mutual phasing among the individual clock gene expression rhythms, their relative phasing to the light-dark regime, and their amplitudes. An adult-like state was achieved around P20. The foster study revealed that during the prenatal period, the maternal circadian phase may partially modulate development of the colonic clock. Postnatally, the absence and/or presence of rhythmic maternal care affected the phasing of the clock gene expression profiles in pups at P10 and P20. A reversal in the colonic clock phase between P10 and P20 occurred in the absence of rhythmic signals from the pup SCN. The data demonstrate ontogenetic maturation of the colonic clock and stress the importance of prenatal and postnatal maternal rhythmic signals for its development. These data may contribute to the understanding of colonic function-related diseases in newborn children. colon; circadian clock; clock gene; ontogenesis; circadian entrainment THE GASTROINTESTINAL TRACT begins functioning immediately after birth with demands to digest, absorb, and secrete water, electrolytes, and nutrients. Concurrently, the gastrointestinal tract also provides a selective barrier against the noxious environment of the gut lumen, which is continuously exposed to a variety of commensal and pathogenic microbes and antigens. During ontogenesis, the gut morphology and function undergo major modifications, which are already apparent during the prenatal period and continue during early postnatal development until weaning (for review, see Ref. 15). The primitive gut tube is established early prenatally, which coincides with the development of the enteric nervous system (3). After the gut tube is fully formed, the epithelium, mesenchyme, and lumen undergo expansion followed by epithelium reorganization. During that period, villi are formed in a rostrocaudal wave along the entire intestinal tract. Later, the spaces between the epithelial folds become populated by cells that represent proliferating compartments of the crypts (11). In rodents, colonic crypts are formed only after birth, and their morphological architecture further develops postnatally. Early postnatally, the immature colon is capable of transporting nutrients, such as carbohydrates and amino acids (1, 18), but this ability rapidly disappears with age. In rats, th...

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“…In adult guinea pigs, caffeine can also induce intestinal smooth muscle relaxation Articles by facilitating the inhibitory responses to isoprenaline, cyclic 3'-5'-adenosine mono-phosphate, and papaverine (18). Rodents are a suitable animal model to evaluate the caffeine effect on preterm neonates given that at birth their gastrointestinal function is developmentally comparable to 32-wk gestation infants (31). In this study, we demonstrated that the caffeine-induced relaxant effect in newborn rat gastric muscle is equally dependent on ryanodine receptors.…”

Section: Discussionmentioning

confidence: 99%

Caffeine impairs gastrointestinal function in newborn rats

2015

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Background: Feeding intolerance is commonly documented in premature infants. Caffeine is routinely utilized for apnea of prematurity treatment and known to reduce the lower esophageal sphincter (LES) muscle tone, but the caffeine effect on the newborn gastrointestinal function is unknown. We hypothesized that caffeine impairs esophageal and gastrointestinal motor function. As such, we investigated the drug effect on the tissue's mechanical properties and the newborn rat's in vivo gastric emptying rate. Methods: The effects of caffeine on LES, gastric fundal and antrum, as well as ileal and colonic muscle force potential and relaxation response, were measured in newborn and adult rats. The caffeine-induced (10 mg/kg i.p.) newborn gastric emptying rate changes were evaluated following 3 h of fasting. results: Caffeine relaxed the precontracted LES and fundal muscle (P < 0.01), reduced the gastric and intestinal muscle contraction (P < 0.01), and delayed the pups' gastric emptying time (P < 0.01). The caffeine-induced muscle relaxant effect was independent of age and mediated via ryanodine receptors. conclusion: Caffeine administration to newborn rats at a dose comparable to the one therapeutically used for preterm neonates impairs LES and gastrointestinal motor function. Further clinical investigation on the possible contribution of caffeine to neonatal feeding intolerance is warranted.

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Postnatal development of myenteric neurochemical phenotype and impact on neuromuscular transmission in the rat colon

Cited by 56 publications

References 28 publications

Building a second brain in the bowel

Building a second brain in the bowel

Development and entrainment of the colonic circadian clock during ontogenesis

Caffeine impairs gastrointestinal function in newborn rats

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