Postnatal development of the distribution of nitric oxide-producing neurons in the rat corpus callosum

Barbaresi, Paolo; Mensà, Emanuela; Sagrati, Andrea; Graciotti, Laura

doi:10.1016/j.neures.2019.02.005

Cited by 3 publications

(2 citation statements)

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“…NOS are complex proteins found in a family of three isoforms which differ in their structure and distribution. Neuronal NOS (NOS1/nNOS), expressed in a subpopulation of neurons and endothelial NOS (NOS3/ eNOS) expressed in endothelial cells, both being Ca 2+ calmodulin-dependent and constituve enzymes, while the third isoform inducible NOS (NOS2/iNOS) is primarily present in immune system cells and its activation is Ca 2+ calmodulin independent (Barbaresi et al, 2020;Chachlaki and Prevot, 2020). In the brain, endogenous NO acts as a diffusible neurotransmitter mainly produced by nNOS, activated upon glutamate binding to postsynaptic N-methyl-Daspartate (NMDA) receptors (Chachlaki and Prevot, 2020;Fernando et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Since Nnos has been identified at different time points in various cell types of the central nervous system (CNS) (Maccallini and Amoroso, 2023), in certain areas of the brain, it is only temporarily expressed (Chung et al, 2004;Imura et al, 2005) and there is a gradual increase in others (Tripathi et al, 2023) during embryonic and postnatal development. Additionally, during the first month of postnatal life, histochemical and immunocytochemical research have characterized the distribution of NO-producing neurons in the rat corpus callosum structure (cc) (Barbaresi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

Ibouzine-Dine,

Berkiks,

Lamtai

et al. 2024

AAVS

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The postnatal period represents the critical window referring to specific intervals of time during which the brain's development exhibits increased sensitivity to specific types of learning and external influences. This period is usually associated with the development of age-related neurodevelopmental processes. Nitric oxide (NO) is an essential signaling molecules that play an important role in physiological processes including neuronal survival and differentiation, neurogenesis, synaptogenesis, pruning, and brain plasticity. In the present study, we aimed to determine the activity of NO during the early and late critical periods of structural and functional maturation of the central nervous system (CNS). In this study, we focused on the prefrontal cortex, hippocampus, striatum, and hypothalamus of male and female "Wistar" rat pups, as these areas have differential developing states. NO level was determined on postnatal days (PND)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

Ibouzine-Dine,

Berkiks,

Lamtai

et al. 2024

AAVS

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Spacing spheroids, curl-up and coiled neuritic plexus of the sacral spinal cord of aged dog: Hypothesis based on continued NADPH diaphorase histological observations

Jia

Hou

et al. 2020

Preprint

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NADPH diaphorase (N-d) neurons distribute in spinal cord and function for visceral sensation and autonomic regulation. N-d positive neurons innervate pelvic organs. In previous investigation, we report that aging-related N-d body (ANB) in the lumbosacral spinal cord in aged rat and megaloneurite in the sacral spinal cord in aged dog. This article was a continued data report of aging-related N-d alterations in aged dog. N-d positivity in aged spinal cord has revealed a certain of morphological profiles in the spinal cord of several species. However, we still found some denoted N-d neurodegenerative changes that we failed to notice in our previous studies when reexamination of the sacral spinal cord of aged dog. In the horizontal section, spacing spheroids in the superficial laminae of the dorsal horn, curl-up and coiled neurites in the intermediate zone were detected in the sacral spinal cord. The ANB and vacuolar neurite were also detected. Vacuolar degeneration also occurred in the dorsal ganglia at the sacral segment. The curl-up and coiled neurites did not occur in the lumbothoracic segment, but the ANB and vacuolar neurite were scatteringly detected in in the lumbothoracic segment of aged dog. The results suggested that the N-d sensory inputs interrupted and disconnected with integration of autonomic centers and output circuits of regulating urogenital organs during the aging. These specialized profiles were speculated that the N-d neurite deterioration of visceral sensory circuit implicated dysfunction of pelvic organs in the aging. Megaloneurite and fiber dilation may make backward reasoning to N-d fiber architecture under normal condition.Urinary incontinence is clinical epidemiological health issues of older adults[1] Constipation is also common in adults older than 60 years [2]. Generally, constipation is considered for the peripheral enteric neurodegeneration [3,4]. Erectile dysfunction in men is also a sign of an underlying aging condition [5]. The sensation of the aging spinal cord could be changed in the singling circuitry in the dorsal horn of the lumbosacral segment [6]. The impact of aging on the cellular composition of the spinal cord reveals aging-associated changes in the numbers of neurons and non-neuronal cells [7].The sacral spinal cord innervates of the urogenital organs [8,9]. The relevant cell bodies of autonomic neurons distribute in the dorsal horn, intermediolateral nucleus (IML), dorsal commissural nucleus (DCN). In the dog [9, 10] and monkey [11], autonomic neurons also locate in the anterior horn. Many neuropeptides distribute in these neurons [12,13]. The NADPH diaphorase (N-d) is also important neuronal enzyme identical to nitric oxide synthase (NOS) distributed in the autonomic spinal cord[14-16], although some experiments may not completely reach the consistent conclusion [17][18][19][20]. Up to date, the N-d is also commonly used to investigate the neurodegenerative diseases[21-23]. Aging-related N-d alterations have been studied in the sacral spinal cord in the rat [18], dog[2...

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Intrinsic organization of the corpus callosum

Barbaresi,

Fabri,

Lorenzi

et al. 2024

Front. Physiol.

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The corpus callosum—the largest commissural fiber system connecting the two cerebral hemispheres—is considered essential for bilateral sensory integration and higher cognitive functions. Most studies exploring the corpus callosum have examined either the anatomical, physiological, and neurochemical organization of callosal projections or the functional and/or behavioral aspects of the callosal connections after complete/partial callosotomy or callosal lesion. There are no works that address the intrinsic organization of the corpus callosum. We review the existing information on the activities that take place in the commissure in three sections: I) the topographical and neurochemical organization of the intracallosal fibers, II) the role of glia in the corpus callosum, and III) the role of the intracallosal neurons.

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Postnatal development of the distribution of nitric oxide-producing neurons in the rat corpus callosum

Cited by 3 publications

References 101 publications

Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

Spacing spheroids, curl-up and coiled neuritic plexus of the sacral spinal cord of aged dog: Hypothesis based on continued NADPH diaphorase histological observations

Intrinsic organization of the corpus callosum

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