Postnatal distribution ofcpp32/caspase 3 mRNA in the mouse central nervous system: An in situ hybridization study

Bilbao, Fabienne de; Guarin, Ernesto; Nef, Patrick; Vallet, Philippe; Giannakopoulos, Pantéleimon; Dubois‐Dauphin, Michel

doi:10.1002/(sici)1096-9861(19990705)409:3<339::aid-cne1>3.0.co;2-q

Cited by 72 publications

(50 citation statements)

References 64 publications

(89 reference statements)

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“…These molecules have been implicated in cell adhesion and transmembrane and intracellular signalings. In addition, other FK-down genes, such as doublecortin, Homer2, caspase-3, and MARCKS-like protein (Mlp, also termed MRP), have been shown to be expressed in the EGLb or EGLa and EGLb and down-regulated during postnatal cerebellar development (26)(27)(28)(29). The FK-down genes could thus play a pivotal role in cell-cell interaction, migration, and neurite extension of premigratory immature granule cells.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, doublecortin, Homer2, MARCKS-like protein, caspase-3, and VGluT2 genes, which are all FK-down genes, have been reported to be significantly expressed in the EGL during the postnatal period (26)(27)(28)(29)(30). We performed in situ hybridization of cerebellar sections at P8 and The numbers and proportions of the Depo-down genes and Depo-up genes (a total of 87 genes) (C) and those of the FK-up genes and FK-down genes (a total of 77 genes) (D) are indicated in each group of the Dev-up genes, Dev-down genes, and non-Dev genes.…”

Section: Expression Of Fk506-responsive Genes In Premigratory and Posmentioning

confidence: 95%

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A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Sato

Suzuki²,

Yamazaki³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

Section: Expression Of Fk506-responsive Genes In Premigratory and Posmentioning

confidence: 95%

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Sato

Suzuki²,

Yamazaki³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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“…These results are consistent with reports demonstrating that caspase-3 mRNA and protein expression strongly decrease during brain development. 48,49 In addition, differential expression of Apaf-1 and caspase-3 during brain maturation has recently been demonstrated and shown to correlate with susceptibility to cytochrome c-dependent caspase activation. 39 Furthermore, defective cytochrome c-dependent caspase activation due to diminished or absent Apaf-1 has been reported in cancer cell lines.…”

Section: Em Of Three Independent Experimentsmentioning

confidence: 99%

Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development

2002

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Apoptosis is the mode of photoreceptor cell death in many retinal dystrophies. Exposure of Balb/c mice to excessive levels of light induces photoreceptor apoptosis and represents an animal model for the study of retinal degenerations. Caspases have emerged as central regulators of apoptosis, executing this tightly controlled death pathway in many cells. Previously we have reported that light-induced photoreceptor apoptosis occurs independently of one the key executioners of apoptosis, caspase-3. This present study extends these results reporting on the lack of activation of other caspases in this model including caspases-8, -9, -7, and -1. Furthermore, photoreceptor apoptosis cannot be inhibited with the broad range caspase inhibitor zVAD-fmk indicating that lightinduced retinal degeneration is caspase-independent. We demonstrate that cytochrome c does not translocate from mitochondria to the cytosol during photoreceptor apoptosis. We also show that during retinal development apoptotic protease activating factor (Apaf-1) protein levels are markedly decreased and this is associated with the inability to activate the mitochondrial caspase cascade in the mature retina. In addition, there is also a significant reduction in expression of caspases-3 and -9 during retinal maturation and these levels do not increase following light exposure. Finally, we show that the calcium-dependent proteases calpains are active during light-induced retinal degeneration and establish that the calcium channel blocker D-cis-diltiazem completely inhibits photoreceptor apoptosis.

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“…One of the mechanisms by which BCL-2 may exert its neuroprotective action is through inhibition of the pro-apoptotic protein BAX (Oltvai et al, 1993;Antonsson et al, 1997;Mahajan, 1998). BAX mRNA is expressed at high levels in the postnatal mouse brain (De Bilbao et al, 1999). BAX protein expression levels may gradually decline in the cerebellum through the first 21 d of development, although expression levels of BAX remain high in PCs in the adult (Vekrellis et al, 1997).…”

Section: Purkinje Cell Death In the Grid2 Lc/؉ Mutantmentioning

confidence: 99%

BaxInactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons

2000

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Lurcher is a gain-of-function mutation in the ␦2 glutamate receptor gene (Grid2) that turns the receptor into a leaky ion channel. The expression of the Lurcher gene in heterozygous (Grid2 Lc/ϩ ) mutants induces the death of almost all Purkinje cells starting from the second postnatal week. Ninety percent of the granule cells and 60-75% of the inferior olivary neurons die because of the loss of their target neurons, the Purkinje cells. The apoptotic nature of the neurodegeneration has been demonstrated previously by the presence of activated caspase-3 and DNA fragmentation. Bax, a pro-apoptotic gene of the Bcl-2 family, has been shown to be involved in developmental neuronal death. To study the role of Bax in Grid2 Lc/ϩ neurodegeneration, double mutants with Grid2 Lc/ϩ mice and Bax knock-out mice (BaxϪ/Ϫ) were generated. Bax deletion had no effect on the death of Purkinje cells and inferior olivary neurons, although a temporary rescue of some Purkinje cells could be detected in P15 Grid2 Lc/ϩ ;BaxϪ/Ϫ animals. From postnatal day 15 (P15) to P60, the number of granule cells in Grid2 Lc/ϩ ;BaxϪ/Ϫmice did not significantly change and was significantly increased compared with the number found in Grid2 Lc/ϩ ;Baxϩ/ϩ mice. Granule cell number in P60 Grid2 Lc/ϩ ;BaxϪ/Ϫ mice corresponded to 70% of the number found in wild-type mice. Our results show that Bax inactivation in Grid2 Lc/ϩ mice does not rescue intrinsic Purkinje cell death or the target-related cell death of olivary neurons, but Bax inactivation does inhibit persistently target-related cell death in cerebellar granule cells.

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Postnatal distribution ofcpp32/caspase 3 mRNA in the mouse central nervous system: An in situ hybridization study

Cited by 72 publications

References 64 publications

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development

BaxInactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons

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