Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats

Reid, Danielle; Eller, Lindsay K.; Nettleton, Jodi E.; Reimer, Raylene A.

doi:10.1007/s00394-015-1047-2

Cited by 40 publications

(20 citation statements)

References 69 publications

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“…In some cases, the administration of specific dietary components improved host health and also increased the Akkermansia population. Such compounds include polyphenols [19,47,48], fructo-oligosaccharide [49,50], conjugated linoleic acid [51], oat bran [52], type 2 resistant starch from high-amylose maize [53], fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) [54], whole grain barley [55] and polyamines [56,57], red pitaya [58] Bifidobacterium animalis subsp lactis LMG P-28149 [59], maize-derived non-digestible feruloylated oligo-and polysaccharides [60], amongst others. Interestingly, medicinal herbs (Flos Lonicera and fermented Rhizoma Atractylodis Macrocephalae) as well as fungi (Ganoderma lucidum) that are traditionally considered in Asian culture as medicine [61e63], also increased the proportion of Akkermansia with a concomitant beneficial effect on host metabolism.…”

Section: Modulation By Dietmentioning

confidence: 99%

Akkermansia muciniphila and its role in regulating host functions

Derrien

Belzer

Vos

2017

Microbial Pathogenesis

790

548

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Akkermansia muciniphila is an intestinal bacterium that was isolated a decade ago from a human fecal sample. Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. Although it was isolated quite recently, it has rapidly raised significant interest as A. muciniphila is the only cultivated intestinal representative of the Verrucomicrobia, one of the few phyla in the human gut that can be easily detected in phylogenetic and metagenome analyses. There has also been a growing interest in A. muciniphila, due to its association with health in animals and humans. Notably, reduced levels of A. muciniphila have been observed in patients with inflammatory bowel diseases (mainly ulcerative colitis) and metabolic disorders, which suggests it may have potential anti-inflammatory properties. The aims of this review are to summarize the existing data on the intestinal distribution of A. muciniphila in health and disease, to provide insight into its ecology and its role in founding microbial networks at the mucosal interface, as well as to discuss recent research on its role in regulating host functions that are disturbed in various diseases, with a specific focus on metabolic disorders in both animals and humans.

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Section: Modulation By Dietmentioning

confidence: 99%

Akkermansia muciniphila and its role in regulating host functions

Derrien

Belzer

Vos

2017

Microbial Pathogenesis

790

548

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“…abundance in the intestine. In animal studies, the administration of any kind of nutrients that increased the amount of Akkermansia muciniphila improved host physiological conditions consequently (23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Global Scientific Output Trend for Akkermansia muciniphila Research: A Bibliometric and Scientometric Analysis

Dehghanbanadaki

Aazami

Raftar

et al. 2020

Preprint

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Background Akkermansia muciniphila is an anaerobic bacterium residing in the healthy intestinal tract of host and its quantity has a negative correlation with various host diseases. This study for the first time provides a holistic bibliometric aspect of Akkermansia research in the literature and shows the hot topic terms of these articles in any period of time. Methods Scopus database was selected to retrieve documents relevant to Akkermansia in any language up to 2018. The bibliometric profile of Akkermansia articles including subject area, year distribution, citations, institutions, journals, authors, and countries was systematically characterized and the collaboration networks of authors and countries as well as the burst detection algorithm of the words in the titles, abstracts and keywords were visualized. Results There is a progressive growing trend in research on Akkermansia from 2004 to 2018 with a total of 668 articles during this period. Out of 518 original articles, there are 301 animal studies (222 studies on mice) and 150 human studies. Also, 65 various diseases were investigated in these studies. The most focused conditions are obesity (71 articles) and type2 diabetes (39 articles). The United States is the leading country on Akkermansia publications (n=184), followed by China (n=156). PLoS ONE is the most dominant journal with 34 Akkermansia publications. In addition, “cancer” is the hot topic of recent Akkermansia research. Conclusion Akkermansia research is of progressive interest during the last decade and the studies on this subject move towards its relationship with cancer and its promising effect on health.

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“…In addition, soy protein and threonine can be used instead of mucin, and a certain amount of N-acetylglucosamine, N-acetylgalactosamine, and glucose can be added to form a mixed medium to cultivate A. muciniphila, and the biomass of which is not significantly different with that grown in BPM 13,34 . In addition, the study found that by adding fructooligosaccharides [35][36] , metformin [37][38] , polyphenols [39][40][41][42] , probiotics 43 and fish oil unsaturated fatty acids 44 diabetes. The main metabolite of A. muciniphila is a short-chain fatty acid.…”

Section: Effect Of Different Media On a Muciniphila Biomassmentioning

confidence: 99%

Study of growth, metabolism, and morphology ofAkkermansia muciniphilawith anin vitroadvanced bionic intestinal reactor

Zhan

et al. 2020

Preprint

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AbstractAkkermansia muciniphila, a human intestinal microbe, is a potential next-generation probiotic. Therefore, studying the in vitro cultivation of A. muciniphila is important. In this study, the brain heart extract (BHI) broth and porcine- (PM), human- (HM), BHI-added porcine- (BPM), and BHI-added human-derived (BHM) mucin media were used to ferment A. muciniphila in vitro. Results showed that HM had the highest biomass of A. muciniphila (2.89 g/L). The main metabolites of HM and PM were acetic and butyric acids, and the main metabolites of BHI medium, BPM, and BHM were acetic, propionic, isobutyric, butyric, isovaleric, and valeric acids. The butyric acid concentrations of BPM and BHM reached 9.88 and 12.88 mM, respectively. A. muciniphila had the highest outer membrane protein concentration in PM and HM, reaching 24.36 and 26.26 μg/mg, respectively. Electron microscopy showed that the outer membrane thickness of A. muciniphila was positively correlated with the outer membrane protein concentration. The appearance of A. muciniphila was round or elliptical in five kinds of culture media. In the BHI medium, A. muciniphila had the smallest diameter and length of 871 nm. This study provides a theoretical basis for the regulation of host metabolism of A. muciniphila.ImportanceThis article explains the growth, metabolism and appearance of Akkermansia muciniphila previously described as strictly anaerobic bacteria in different nutrient media. Interestingly, the nutritional composition has a presumptive relationship with A. muciniphila biomass, outer membrane protein concentration and thickness, and diameter. At conditions containing mucin as sole carbon and nitrogen sources, the metabolites of A. muciniphila are acetic and butyric acids. This study provides a certain reference for the mechanism of action of A. muciniphila in the host.

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Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats

Abstract: Postnatal consumption of OFS by rats raised in SL was able to attenuate body fat and glycaemia to levels seen in NL rats. OFS appears to influence satiety hormone and gut microbiota response similarly in overnourished and control rats.

Cited by 40 publications

References 69 publications

Akkermansia muciniphila and its role in regulating host functions

Akkermansia muciniphila and its role in regulating host functions

Global Scientific Output Trend for Akkermansia muciniphila Research: A Bibliometric and Scientometric Analysis

Study of growth, metabolism, and morphology ofAkkermansia muciniphilawith anin vitroadvanced bionic intestinal reactor

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