Postoperative Analgesic Effects of Carprofen Following Osteotomy and Laparotomy in Dogs

Erol, Muharrem; Izci, Celal

doi:10.3923/javaa.2011.922.927

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Orally delivered pain control in the dog remains challenging because of limited canine‐specific research evaluating potential medications, differences in metabolism of drugs between species, and imprecise pain evaluation in dogs. Nonsteroidal anti‐inflammatory drugs (NSAID) are US Food and Drug Administration (FDA) approved as perioperative analgesics and have been found to improve limb function in clinical perioperative pain studies . However, many dogs have contraindications to NSAID use, and a viable alternative orally delivered pain control is required in the dog.…”

Section: Introductionmentioning

confidence: 99%

Once daily oral extended‐release hydrocodone as analgesia following tibial plateau leveling osteotomy in dogs

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Once daily oral extended‐release hydrocodone as analgesia following tibial plateau leveling osteotomy in dogs

et al. 2018

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“…Several metabolic alterations are known to occur as the result of pain. The most important changes are the increase in the levels of stress hormones noradrenaline, adrenaline, cortisol and ACTH (23). Serum cortisol levels were measured in this study; the control group values were signifi cantly elevated at postoperative 1 and 4 h with respect to baseline.…”

Section: Tab 2 Blood Chemistry Values In the Control (N=7) And Dexkmentioning

confidence: 99%

Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy

Saritas¹,

Sarıtaş²,

Pamuk³

et al. 2015

BLL

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Abstract:Objective: To investigate the postoperative analgesic effects of preemptive dexketoprofen trometamol in dogs subjected to ovariohysterectomy (OHE). Material and methods: Seventeen adult bitches of various breeds were used in this study. The dogs were randomly allocated into of two groups. Subjects in the dexketoprofen trometamol (DEX) group (n = 10), received intravenous (i.v.) dexketoprofen trometamol, 1 mg/kg, 15 minutes before premedication, while those assigned to the control (C) group (n = 7) were given no analgesics prior to premedication. Pain level was assessed by two researchers before the administration of anaesthesia (15 minutes before start) and 0, 1, 2, 4 and 6 hours after surgery. A modifi ed University of Melbourne Pain Scale (UMPS) was used to evaluate pain in both groups. Results: Serum cortisol level changed from 0 to 1 h and from 0 to 1 to 4 h were compared between the groups; the increase in the C group was statistically signifi cant. The modifi ed UMPS was applied to both groups at baseline and postoperative 1, 2, 4 and 6 h. According to this test, the values for DEX were signifi cantly lower than controls at 4 and 6 h (p < 0.001). Conclusion: Stable vital signs with unchanged biochemical parameters on dexketoprofen administration are a promising fi nding. The clinical advantage shown by the pain scale difference and the low serum cortisol levels should qualify dexketoprofen for preemptive pain management in dogs (Tab. 5, Fig. 2, Ref. 30). Text in PDF www.elis.sk.

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“…Carprofen is an nonsteroidal anti-inflammatory drug of the carbazole group and is a propionic acid derivative. It is especially highly effective in controlling the pain caused by degenerative joint diseases and is also quite effective in eliminating post-operative soft tissue and orthopedic pain [ 18 - 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cortisol concentration, pain and sedation scale in free roaming dogs treated with carprofen after ovariohysterectomy

Nenadović

Vučinić

Radenkovic-Damnjanovic

et al. 2017

Vet World

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Background and Aim:One of the topic issues in animal welfare activities is the free roaming dog welfare especially in developing countries such as Serbia. The way of controlling population of free roaming dogs is their reproduction with the method of “Catch-Neuter-Release.” This complex process consists of capturing free roaming dogs in public areas, sterilizing, and returning them to the public area from which they were temporarily removed. Ovariohysterectomy present the period with a high intensity of stress reaction since many veterinarians in Serbia do not use analgesia for this group of dogs. The aim of this study was to compare the serum cortisol concentration before and after ovariohysterectomy and the level of post-operative pain and sedation in a group of free roaming female dogs treated with carprofen after surgical intervention and in a group with no treatment.Materials and Methods:The study was performed on a total of 20 female dogs under the program for free roaming dog control. Free-roaming dogs were captured in public areas by the communal animal hygiene service and were transported between 30 and 45 min to the clinic of a veterinary practice. Treatment began at 10:00 h on the next day and the bitches were kept in cages until they were returned to public locations from which they were temporarily removed to be sterilized. The G2 group received before closing the incision line carprofen in one dosage of 4 mg/kg given by subcutaneous injection into the scruff. Rescue protocol with carprofen was provided for G1 after 24 h following ovariohysterectomy same dosage as G2. Blood (2 ml) was collected from the cephalic vein of each dog in disposable plastic syringes, containing heparin (1:1000) 4 times: Before ovariohysterectomy, 30, 120 min and 24 h following ovariohysterectomy. Cortisol concentration was determined by enzyme-linked immunosorbent assay. The multifactorial pain and sedation scale were used for the assessment of pain and sedation.Results:In both groups, the lowest values of serum cortisol concentration were obtained before ovariohysterectomy. Cortisol levels in both groups were significantly higher (p<0.01) 30 and 120 min after ovariohysterectomy and showed a decreasing trend toward the end of the observation period (24 h). The results obtained 15 and 30 min after the surgical intervention have revealed a statistically significant difference between the groups (p<0.05) showing that female dogs treated with carprofen had a lower value on the pain scale and a higher value on the sedation scale compared to the group with no treatment.Conclusion:Carprofen provides both a restful consequence of sedation and a rapid return to a more normal physiological and behavioral state in dogs after ovariohysterectomy.

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Postoperative Analgesic Effects of Carprofen Following Osteotomy and Laparotomy in Dogs

Cited by 5 publications

References 13 publications

Once daily oral extended‐release hydrocodone as analgesia following tibial plateau leveling osteotomy in dogs

Once daily oral extended‐release hydrocodone as analgesia following tibial plateau leveling osteotomy in dogs

Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy

Cortisol concentration, pain and sedation scale in free roaming dogs treated with carprofen after ovariohysterectomy

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