Background: Atresia coli is an intestinal anomaly. Generally, absence of defecation in calves less than 10 days old, diminishing appetite, progressing abdominal distention and time-developing depression are reported in atresia coli. Although a calf consumes its milk normally in first days, loss of appetite develops over time. Occasional minor pain indications are observed. The objective of this study was to evaluate of hematologic, blood gases, cardiac biomarkers and serum biochemical parameters before operation in calves with atresia coli, and to investigate relationship with prognosis of these parameters. Materials, Methods & Results:Thirty calves with atresia coli and 6 healthy calves for control were used as material. Poor suction reflex, anorexia, dehydration, abdomen-kicking, frequent leg movement, abdominal distension and depression were observed in calves brought to the clinic. Some calves presented swashing sound depending on content of intestines when abdomen was shaken. Intestine atresia was diagnosed by history and clinical examination. After clinical examination, operation was performed. All calves were observed during 10 days after operation. Fifteen of 30 calves died during 10 days after operation. The blood lactate, WBC, LDH and CK-MB levels in non-surviving calves with atresia coli were significantly higher compared to control calves. The venous blood pH level was significantly lower in non-surviving calves compared to surviving calves. In addition, when compared to the control group, the blood pCO 2 level was significantly higher in non-surviving and surviving calves with atresia coli while the pO 2 and O 2 saturation levels were significantly lower. Discussion: In calves with intestinal atresia, hematologic parameters are normal in first 48 h of disease. However, leukocytosis and shift to the left have been reported over time. However, leukocytosis due to peritonitis, bacterial overgrowth, etc. have been reported over time. It was seen that leukocyte numbers of non-surviving calves with atresia coli in this study were significantly higher, but leucocyte increase in surviving calves was seen to be statistically insignificant. Leukocyte increased in non-surviving calves with atresia may be associated with excessive bacterial reproduction and peritonitis. Blood lactate level is a commonly used marker for severity of disease in humans and lactate has a prognostic value in adult horses with colic and foals with critical disease. In this study, lactate level in non-surviving calves with atresia coli was significantly higher with respect to surviving calves and control calves. In this result, lactate can be evaluated as a prognostic indicator in calves with atresia coli. Creatine kinase-MB fraction and troponins are used in determination of cardiac damage in veterinary medicine. The fact that serum blood cTnI and CK-MB levels of non-surviving calves with intestinal atresia in this study were higher than surviving calves with atresia coli and control calves suggested that endotoxemia related cardiac da...

Introduction: Clinical doses of anaesthetic agents were administered to rabbits and effects on the brain, heart, and liver were investigated biochemically and histopathologically. Material and Methods: The rabbits were randomly divided into three main groups (16 rabbits each) and each group into study (n = 8) and control (n = 8) groups. All study group rabbits received 3 mg/kg of midazolam (M) intramuscularly. Group 1.1 (M) received nothing further, group 2.1 (MK) also received 25 mg/kg of ketamine, and group 3.1 (MKI) besides ketamine was also given 2% isoflurane to induce anaesthesia for 30 min. NaCl solution in the same volume as midazolam and ketamine was injected into the controls. Results: In clinical evaluation significant differences were detected in respiratory and heart rates. In blood gas analysis the PO2 and PCO2 values showed statistical differences in anaesthesia intervals. Significant biochemical value changes were recorded in creatine kinase-Mb, glucose, and total protein. Histopathological liver examinations revealed higher total apoptotic and normal cell numbers in the MK than in the M and MKI groups. Apoptotic cell numbers were statistically significant in M and MK groups. Conclusion: Anaesthetic agents may increase programmed apoptosis. The MKI anaesthetics combination was found to cause less cell destruction in general than the other study groups. It was indicated that MKI was the safer anaesthetic combination in rabbits.

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Buzağıda jejenum invaginasyonunun operatif tedavisi: Olgu sunumu Öz Bu vaka sunumunda 5 aylık bir erkek buzağıda teşhis edilen jejunum invaginasyonunun klinik, laboratuar ve operasyon bulguları değerlendirildi. Tanımlanan klinik vakada hayvanın 3 gündür iştahsız olduğu ve defekasyon yapmadığı sahibinden öğrenildi. İç Hastalıkları kliniğinde yapılan klinik ve laboratuar muayenelerinden sonra hayvan cerrahi kliniğine sevk edildi. Sol açlık çukurluğundan laporatomi operasyonu yapıldı. Operasyonda bağırsaklar patolojik vaziyet değişikliği yönünden kontrol edildi. Operasyon esnasında yapılan muayenede ventral hattın hafif sağında katı kıvamlı bağırsak segmenti palpe edildi. Palpe edilen bağırsak segmenti karın boşluğundan çıkarıldığında invagine olmuş jejunum olduğu görüldü. İnvagine kısım ödematöz, siyanotik ve fibröz adezyonların bulunmasından dolayı rezeksiyonu ve uç uca anostomozu yapıldı. Taburcu edilen buzağı hakkında hasta sahibinde bilgi alındı. Sonuç olarak bağırsak invaginasyonunun 5 aylık buzağılarda nadiren görüldüğü, teşhisinin experimental laparotomi ile koyulabileceği ve bu sürede rutin cerrahi operasyon ile tedavisinin yapılabileceği kanısına varıldı.