Postoperative Cognitive Dysfunction

Rundshagen, I.

doi:10.3238/arztebl.2014.0119

Cited by 272 publications

(328 citation statements)

References 40 publications

Supporting

Mentioning

282

Contrasting

Unclassified

Order By: Relevance

“…15,16 As described previously, POCD was defined as a decline of [ 20% from preoperative test scores in at least two of seven tests. 17 Cognitive function was assessed by the same anesthesiologist blinded to group allocation and not involved in intraoperative management.…”

Section: Methodsmentioning

confidence: 99%

Effects of anesthetics on early postoperative cognitive outcome and intraoperative cerebral oxygen balance in patients undergoing lung surgery: a randomized clinical trial

Egawa

Inoue

Nishiwada

et al. 2016

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Effects of anesthetics on early postoperative cognitive outcome and intraoperative cerebral oxygen balance in patients undergoing lung surgery: a randomized clinical trial

Egawa

Inoue

Nishiwada

et al. 2016

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

“…Postoperative cognitive dysfunction (POCD) is a frequent and serious complication after general anesthesia [1]. POCD is known to have a negative impact on the quality of life in affected patients [2].…”

Section: Introductionmentioning

confidence: 99%

“…General anesthesia might cause neuroinflammation in the developing brain [7], but it is difficult to determine cognitive changes caused by the anesthetic agent per se. POCD is usually transient, and it is difficult to establish clear diagnostic criteria for POCD [1,8]. Elucidation of the biological mechanism of POCD would be useful for improving the diagnosis and prevention of POCD.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Effects of Sevoflurane Anesthesia in Different Maturing Stages of the Mouse Hippocampus by Transcriptome Analysis

Hayase¹,

Tachibana²,

Yamakage³

2017

J Aging Sci

View full text Add to dashboard Cite

Purpose: Postoperative cognitive dysfunction (POCD) is a serious complication after general anesthesia. POCD is more likely to occur in elderly patients, but the mechanism of POCD has not been fully elucidated. We hypothesized that the difference of mRNA expression profile in the brain depending on the maturing stage causes the difference in the effect of sevoflurane anesthesia. We investigated the mRNA expression profile of hippocampal cells in young mice and in aged mice under sevoflurane anesthesia using transcriptome analysis. Methods:This study was conducted after approval from our institutional animal ethics committee, the Animal Research Center of Sapporo Medical University School of Medicine (project number: 12-033). Eight mice were assigned to two groups: a young group and an aged group. Each of the 4 mice in the two groups was anesthetized with 3.5% sevoflurane for 1 hour. Subsequently, mRNA was isolated from hippocampal cells and RNA sequencing was performed on an Illumina HiSeq 2500 platform. Mapping of the quality-controlled, filter paired-end reads to mouse genomes and quantification of the expression level of each gene were performed using R software. Results:The Lhx9 gene, which is thought to be associated with neuronal inflammation, was the most highly upregulated gene in aged mice. The Epyc gene, which encodes a protein related to the phospholipase-C pathway and ERK signaling, was the most down-regulated gene in aged mice. Conclusions:The findings suggest that sevoflurane anesthesia induces neuronal inflammation via a LIMhomeodomain family related gene in aged mice and causes POCD.

show abstract

“…It has been widely accepted that, apart from the triggering factor of surgery, many factors contribute to the considerable risks associated with POCD, including old age, pre-existing cerebral, cardiac, and vascular diseases, alcohol abuse, low educational level, and intra-and postoperative complications (Rundshagen, 2014). Oxidative stress is described as a disturbed balance between the generation and elimination of reactive oxygen species (ROS) and reactive nitrogen species (RNS) (Yu et al, 2015;Pruchniak et al, 2016), in which condition, antioxidant defense system of the cells cannot coordinate with the increasing ROS and therefore cytotoxicity occurs.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of parecoxib on rat primary astrocytes from oxidative stress induced by hydrogen peroxide

Ling

et al. 2016

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: To investigate the protective effects of parecoxib from oxidative stress induced by hydrogen peroxide (H 2 O 2 ) in rat astrocytes in vitro. Methods: All experiments included 4 groups: (1) negative control (NC) group, without any treatment; (2) H 2 O 2 treatment group, 100 μmol/L H 2 O 2 treatment for 24 h; (3) and (4) parecoxib pretreatment groups, 80 and 160 μmol/L parecoxib treatment for 24 h, respectively, and then treated with 100 μmol/L H 2 O 2 . Several indices were investigated, and the expressions of Bax, Bcl-2, and brain-derived neurotrophic factor (BDNF) were quantified. Results: Compared to the NC group, exposure to H 2 O 2 resulted in significant morphological changes, which could be reversed by pretreatment of parecoxib. In addition, H 2 O 2 treatment led to loss of viability (P=0.026) and increased intracellular reactive oxygen species (ROS) levels (P<0.001), and induced apoptosis (P<0.01) in the primary astrocytes relative to the NC group. However, in the parecoxib pretreatment groups, all the above changes reversed significantly (P<0.05) as compared to the H 2 O 2 treatment group, and were nearly unchanged when compared to the NC group. Mechanical investigation showed that dysregulated Bax, Bcl-2, and BDNF could be implicated in these changes. Conclusions: Our results indicated that parecoxib provided a protective effect from oxidative stress induced by exposure to H 2 O 2 .

show abstract

Postoperative Cognitive Dysfunction

Cited by 272 publications

References 40 publications

Effects of anesthetics on early postoperative cognitive outcome and intraoperative cerebral oxygen balance in patients undergoing lung surgery: a randomized clinical trial

Effects of anesthetics on early postoperative cognitive outcome and intraoperative cerebral oxygen balance in patients undergoing lung surgery: a randomized clinical trial

Determination of the Effects of Sevoflurane Anesthesia in Different Maturing Stages of the Mouse Hippocampus by Transcriptome Analysis

Protective effects of parecoxib on rat primary astrocytes from oxidative stress induced by hydrogen peroxide

Contact Info

Product

Resources

About