Postoperative Delirium and Postoperative Cognitive Dysfunction

Umholtz, Matthew; Nader, Nader D.

doi:10.1007/978-1-4939-9891-3_15

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…7 Even though the exact mechanism behind the development of POD is not known at this time, neuroinflammation generated by the surgery-induced systemic inflammatory process has been suggested to participate in this condition. [8][9][10] While an elevated level of c-reactive protein and interleukin-6 (IL-6) has also been shown to be correlated with POD, 11 whereas one cohort research found no correlation between the level of plasma IL-6 and delirium in elderly hospitalized patients. Consequently, the relationship between plasma markers of inflammation and POD is still unclear.…”

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confidence: 99%

The association between Monocyte‐to‐Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery

Wang

2022

Clinical Laboratory Analysis

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Delirium, which is defined as an acute confessional condition whose characteristics include impaired mental state, is correlated with significant economic costs, high incidence of falls and fall-related accidents, self-removal of medical equipment, long-term hospitalizations, and even increased fatality rates. 1,2 The incidence of postoperative delirium (POD) in heart surgery patients ranges from 50 to 70 percent. According to many prospective studies [3][4][5] , POD is correlated with significant short-term repercussions, such as longer

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confidence: 99%

The association between Monocyte‐to‐Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery

Wang

2022

Clinical Laboratory Analysis

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“…9 CABG on the pump surgery is associated with an increased risk of POCD. 10 The occurrence of POCD following cardiac surgery is most frequently caused by CABG on the pump, with prevalence rates of 37.6% at 7 days and 20.8% at 3 months postoperatively. 11 The microembolization of atheroma plaque, air, and clot from the aorta or cardiopulmonary bypass (CPB), brain hypoperfusion during cardiopulmonary bypass (CPB), and brain hypoperfusion due to systemic inflammation are the mechanisms causing the neurologic impairment of POCD after cardiac surgery.…”

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confidence: 99%

Difference in GFAP Levels in POCD and Non-POCD Patients After on Pump CABG

Nurcahyo

Hadisaputro

Muttaqin

et al. 2022

VHRM

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Introduction On-pump, coronary artery bypass grafting (CABG) is the most common cause of postoperative cognitive dysfunction (POCD) after cardiac surgery. Previous studies showed that the incidence of POCD after cardiac surgery was 60%, higher than non-cardiac surgery with 11.7%. Glial fibrillary acid protein (GFAP) is one of the sensitive biomarkers of brain damage. Previous studies have found that elevated GFAP serum is associated with cognitive impairment. This study aims to measure the difference in GFAP levels in POCD and non-POCD patients after CABG on-pump surgery. Methods This study is a retrospective cohort design study. The data were obtained from 56 subjects undergoing elective CABG on the pump surgery enrolled into two groups consisting of 28 POCD as a case group and 28 non-POCD as a control group. In this study, the ELISA method measured the levels of GFAP biomarkers within 24 hours after surgery. After 72 hours, the patient received a MoCA-INA examination to determine cognitive impairment. Data analysis was carried out by SPSS 23.00 software. Results The mean age of patients in both groups was 60 years and was dominated by males (>85%). POCD patients were found to have a significantly longer duration of cardiopulmonary bypass (CPB) and cross-clamp surgery than non-POCD patients (p = 0.002 and p = 0.004). Postoperative GFAP levels in POCD patients were significantly higher than in non-POCD patients (12.95 ± 7.47 vs 3.80 ± 2.77, p < 0.001). There was a significant increase in GFAP levels compared with non-POCD (8.28 ± 7.24 vs −1.5 ± 3.03, p < 0.001). The area under the curve (AUC) value of GFAP against POCD was 0.887, cut-off GFAP 4.750 with a sensitivity of 92.9% and a specificity of 71.4%. Conclusion POCD patients had higher GFAP levels than non-POCD patients. There are differences in GFAP levels in patients with POCD and non-POCD post-CABG surgery.

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Postoperative Delirium and Postoperative Cognitive Dysfunction

Cited by 2 publications

References 78 publications

The association between Monocyte‐to‐Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery

The association between Monocyte‐to‐Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery

Difference in GFAP Levels in POCD and Non-POCD Patients After on Pump CABG

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