. (2011). Establishment and assessments of a new model for the postoperative fatigue syndrome by major small intestinal resection in rats. Scandinavian Journal of Gastroenterology, 46(11), 1302-1309. DOI: 10.3109/00365521.2011 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Morris water maze test were used to evaluate the degree of POFS. Serum albumin, transferrin, prealbumin and fibronectin were measured to assess the nutritional status, and superoxide dismutase (SOD) and malondealdehyde (MDA) were also measured.
Results:As compared to the other 3 groups, the 70% small intestinal resection group showed the worst general state of health, decreased strength of the tail suspension test and the score of Morris water maze test (P<0.05) after operation.All rats suffering small intestinal resection demonstrated a certain degree of malnutrition and behaviour of depression, and the 70% resection group had the lowest levels of transferrin, prealbumin and fibronectin as compared to the other 3 groups (P<0.05), as well as decreased SOD and increased MDA in serum (P<0.05).
Conclusions:Resection of 70% of the small intestine resulted in typical characteristics of POFS. As this procedure is simple, stable and easily reproducible, it may serve as a model for research on POFS.