Postoperative Pain Therapy After Lumbar Disc Surgery

Filippi, R.; Laun, Jake; Jage, J.; Perneczky, Axel

doi:10.1007/s007010050350

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Opioid analgesics are the traditional first-line medication in this setting but may induce unwanted side effects, such as nausea and vomiting, sedation, and respiratory depression. Several studies have shown that non-opioid analgesics provide effective pain relief in patients with acute postoperative pain after lumbar disk surgery, either as a substitute for or as an adjunct to opioid analgesia (4,7,8). However, this is the first prospective, randomized, double-blind, placebo-controlled study that compares IV administered parecoxib, paracetamol, and metamizol for pain relief in the early postoperative period after lumbar disk surgery.…”

Section: Discussionmentioning

confidence: 94%

The Efficacy of the Non-Opioid Analgesics Parecoxib, Paracetamol and Metamizol for Postoperative Pain Relief After Lumbar Microdiscectomy

Grundmann

Wörnle²,

Biedler³

et al. 2006

Anesthesia &Amp; Analgesia

112

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In this prospective, double-blind, randomized, placebo-controlled study we compared the efficacy of three IV non-opioid analgesics for postoperative pain relief after lumbar microdiscectomy. Eighty healthy patients were randomly divided into 4 treatment groups (n = 20 each) to receive either parecoxib 40 mg, paracetamol 1 g, metamizol 1 g, or placebo IV 45 min before the end of surgery. In the postanesthesia care unit (PACU) patients were treated using patient-controlled analgesia (PCA) with piritramide. In the metamizol group the pain score at arrival in the PACU was significantly lower compared with the paracetamol, parecoxib, and placebo groups. In addition, in the metamizol group significantly fewer patients required additional PCA compared with the other groups studied. However, in those patients who required additional pain therapy in the four treatment groups, there was no significant difference in time to first request for piritramide and cumulative consumption of piritramide as assessed by the PCA data in the PACU. The incidence of adverse side effects was infrequent in all groups. These results suggest that in patients undergoing lumbar microdiscectomy, metamizol is superior to parecoxib, paracetamol, and placebo for immediate postoperative pain relief with minimal side effects.

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Section: Discussionmentioning

confidence: 94%

The Efficacy of the Non-Opioid Analgesics Parecoxib, Paracetamol and Metamizol for Postoperative Pain Relief After Lumbar Microdiscectomy

Grundmann

Wörnle²,

Biedler³

et al. 2006

Anesthesia &Amp; Analgesia

112

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show abstract

“…Of these, 6 studies were excluded. Three studies compared NSAIDs with other active treatment, 9,45,51 duplicated data were presented in 1, 42 outcomes of interest could not be obtained in 1, 43 and the surgery was performed to treat scoliosis in adolescents in 1. 30 Therefore, 17 studies composed of 789 adult patients were included ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…This time point was used for further subgroup and sensitivity analyses. The majority of authors reported pain intensity results over the following intervals: 0-2 hours (8 studies 1,3,17,21,37,41,49,50 ), 4-6 hours (11 studies, 1,9,21,31,35,[37][38][39][40]41 ), 24 hours (14 studies 1,11,21,23,27,31,35,[37][38][39][40]41,50 ), 48 hours (5 studies 11,21,27,31,35 ), and 72 hours (2 studies 27,35 ). Opioid consumption results were reported over the following intervals: 0-2 hours (8 studies 1,3,17,21,37,41,49,50 ), 4-6 hours (6 studies 11,[37][38]…”

Section: Resultsmentioning

confidence: 99%

Nonsteroidal antiinflammatory drugs for postoperative pain management after lumbar spine surgery: a meta-analysis of randomized controlled trials

Jirarattanaphochai¹,

Jung²

2008

SPI

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Object The authors undertook this meta-analysis to assess the efficacy and safety of nonsteroidal antiinflammatory drugs (NSAIDs) in addition to opioid analgesics on perioperative pain management in lumbar spine surgery. Methods The authors searched MEDLINE, Excerpta Medica (EMBASE), The Cochrane Library, CINAHL, PsycINFO, Allied and Complementary Medicine (AMED), and Science Citation Index Expanded databases. In addition, they manually searched key journals and their references. They included randomized trials comparing the use of NSAIDs in addition to opioid analgesics versus opioid analgesics alone after posterior lumbar discectomy, laminectomy, or spinal fusion. Two independent reviewers performed an assessment of the quality of the methods. Results Seventeen studies comprising 400 patients who received NSAIDs in addition to opioid analgesics and 389 patients receiving opioid analgesics alone were included. Patients receiving NSAIDs in addition to opioid analgesics had lower pain scores and consumed fewer opioids than the group receiving opioid analgesics alone. There was no difference in the incidence of adverse effects. Conclusions This meta-analysis provides evidence that the addition of NSAIDs to opioid analgesics in lumbar spine surgery provided better pain control than opioid analgesics alone.

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Erector spinae block for postoperative pain management in lumbar disc hernia repair

Yörükoğlu¹,

İçli̇

Aksu

et al. 2021

J Anesth

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Postoperative Pain Therapy After Lumbar Disc Surgery

Abstract: The results suggest that the application of tramadol and diclofenac during the first 48 hours after lumbar microdiscectomy results in a reduction in postoperative pain without complications. We suggest that the use of this combination can be a beneficial adjunct to lumbar disc surgery.

Cited by 9 publications

References 23 publications

The Efficacy of the Non-Opioid Analgesics Parecoxib, Paracetamol and Metamizol for Postoperative Pain Relief After Lumbar Microdiscectomy

The Efficacy of the Non-Opioid Analgesics Parecoxib, Paracetamol and Metamizol for Postoperative Pain Relief After Lumbar Microdiscectomy

Nonsteroidal antiinflammatory drugs for postoperative pain management after lumbar spine surgery: a meta-analysis of randomized controlled trials

Erector spinae block for postoperative pain management in lumbar disc hernia repair

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