Postoperative radiotherapy-induced leiomyosarcoma in breast cancer: a case report and literature review

Abstract

Radiation-induced sarcoma (RIS) is a late complication of breast cancer radiotherapy, with a very low incidence, long latent period and poor prognosis. Among them, leiomyosarcoma after radiation is an extremely rare radiation-associated sarcoma. In this study, we report a case of radiation-induced leiomyosarcoma 2 years after postoperative radiotherapy for breast cancer. After the diagnosis of leiomyosarcoma, the patient received radical resection of the left chest wall leiomyosarcoma. The patient showed no relapse or progression during the follow-up time of 1 year after operation. Rare occurrence of RIS induced by postoperative radiotherapy in breast cancer and limited experience concerning its diagnosis and treatment bring obstacle to both patients and doctors. Preoperative examinations must be carefully refined. With a perfect coordination between different disciplines, RIS induced by postoperative radiotherapy in breast cancer can be ideally treated with better prognosis. Keywords Breast cancer • Radiotherapy • Leiomyosarcoma Abbreviations RIS Radiation-induced sarcoma RAS Radiation-related sarcoma EC follow TH Epirubicin + cyclophosphamide follow docetaxel + trastuzumab CTV1 Clinical target 1 CTV2 Clinical target area 2 Chest CT Chest computed tomography

Recurrent radiation-associated leiomyosarcoma after postoperative radiotherapy for breast invasive ductal carcinoma: a case report and literature review

“…Radiation dose and field are important factors in the development of RAS. RAS has occurred occasionally after a median dose of 50-55 Gy in 25-27 fractions in the whole breast, followed by a 10-26 Gy boost to the tumour or tumour bed when necessary (4,15,16). In our case, the female patient's clinical and treatment characteristics were consistent with those of a previous study.…”

Post-radiation second malignant tumors after combined treatment of diseases of the upper respiratory tract. Literature review and description of clinical observations

“…Наиболее полный и актуальный обзор литературы по возникновению вторичной лейомиосаркомы в области полей облучения после лечения рака молочной железы представили Liu Y. и соавт. [24]. Авторы проанализировали имеющиеся данные и привели собственное клиническое наблюдение.…”