Postpartum depression and vitamin D: A systematic review

Amini, Shirin; Jafarirad, Sima; Amani, Reza

doi:10.1080/10408398.2017.1423276

Cited by 60 publications

(42 citation statements)

References 47 publications

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“…Importantly, meta-analyses of observational studies documented that low serum 25(OH)D concentrations in pregnancy are associated with increased risk of small for gestational age (SGA) and preterm birth [ 90 , 91 , 92 ]. Some meta-analyses have also shown that vitamin D deficiency is associated with postpartum depression [ 93 , 94 , 95 , 96 ]. Other outcomes such as fetal bone growth or neonatal lung maturation may also be associated with vitamin D status, but more data are needed on these topics [ 97 , 98 ].…”

Section: Pregnancy Outcomesmentioning

confidence: 99%

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Pilz

Zittermann

Obeid

et al. 2018

IJERPH

130

110

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Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.

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Section: Pregnancy Outcomesmentioning

confidence: 99%

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

Pilz

Zittermann

Obeid

et al. 2018

IJERPH

130

110

View full text Add to dashboard Cite

show abstract

“…There have been many studies exploring the potential associations between vitamin D and psychological phenomena or psychiatric disorders, including depression (Alavi, Khademalhoseini, Vakili, & Assarian, 2018; Amini, Jafarirad, & Amani, 2018; Bertone‐Johnson et al, 2012; Dumville et al, 2006; Ghaderi et al, 2017; Jorde, Sneve, Figenschau, Svartberg, & Waterloo, 2008; Khoraminya, Tehrani‐Doost, Jazayeri, Hosseini, & Djazayery, 2013; Pittampalli et al, 2018), anxiety (Armstrong et al, 2007; Huang et al, 2014; Pu et al, 2018), psychotic disorders (Chiang, Natarajan, & Fan, 2016), cognitive impairment (Degner, 2016; Etgen, Sander, Bickel, Sander, & Forstl, 2012), sleep disturbance (Gao et al, 2018; Ghaderi et al, 2017), autism spectrum disorder (Moradi et al, 2018; Patrick & Ames, 2014), and substance use (Ghaderi et al, 2017). Studies investigating the relationship between vitamin D and depression are the most common.…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Cheng

Huang

2020

Depress Anxiety

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Background The several meta‐analyses of the effect of vitamin D on depression have produced inconsistent results and studies dealing with anxiety were not incorporated. There has been no comprehensive analysis of how results are affected by the nature of the sample or the dosage and duration of supplementation. The study is aimed to investigate whether vitamin D supplementation reduces negative emotions and to analyze the possible influence of sample and regimen. Method We conducted a systematic review and meta‐analysis of randomized controlled trials comparing the effect of vitamin D and placebo on negative emotion. Databases were searched for relevant articles published before February 2019. Results The analysis covered 25 trials with a total of 7,534 participants and revealed an effect of vitamin D on negative emotion (Hedges' g = −0.4990, 95% CI [−0.8453, −0.1528], p = .0047, I2 = 97.7%). Subgroup analysis showed that vitamin D had an effect on patients with major depressive disorder and on subjects with serum 25(OH)D levels ≤50 nmol/L. The pooled data from trials of vitamin D supplementation lasting ≥8 weeks and dosage ≤4,000 IU/day indicated that vitamin D had an effect. Conclusions Our results support the hypothesis that vitamin D supplementation can reduce negative emotions. Patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation. But to interpret the results with high heterogeneity should still be cautious.

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“…We identified 12 SRs [31,100,156,[172][173][174][175][176][177][178][179][180] covering 31 original publications between 1998 and 2017, plus five SRs [181][182][183][184][185] on depression in women before and after childbirth (Supplemental Tables S18-S21 and Figure S5). Most studies relied on dimensional self-ratings of depressive symptoms as outcome measures.…”

Section: Resultsmentioning

confidence: 99%

“…Pregnancy, the postpartum period, and in particular the perinatal period are associated with an increased risk of depression in women. In five SRs of mainly high quality, results have been summarised covering largely overlapping subsets of 11 original studies between 2010 and 2017 [181][182][183][184][185]. One SR summarised observational cohort studies [184], two SRs summarised the results of secondary analyses of a RCT and cohort studies [181,183], and one SR summarised the results of a RCT, secondary analyses of two RCTs and cohort studies [182].…”

Section: Postpartum and Antepartum Depression (Primary Prevention)mentioning

confidence: 99%

“…In five SRs of mainly high quality, results have been summarised covering largely overlapping subsets of 11 original studies between 2010 and 2017 [181][182][183][184][185]. One SR summarised observational cohort studies [184], two SRs summarised the results of secondary analyses of a RCT and cohort studies [181,183], and one SR summarised the results of a RCT, secondary analyses of two RCTs and cohort studies [182]. In addition, one high-quality SR by Wang et al (2018) included seven cohort studies, one case-control study and one RCT, which investigated the relationships between circulating levels or supplementation of vitamin D with antepartum or postpartum depression [185].…”

Section: Postpartum and Antepartum Depression (Primary Prevention)mentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.

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Postpartum depression and vitamin D: A systematic review

Cited by 60 publications

References 47 publications

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

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