Postprandial Acid Secretion and Serum Gastrin Response before and after Exclusion of the Proximal Small Intestine in Cats

Abstract

The Heidenhain pouch acid output to graded doses of pentagastrin and the maximal Heidenhain pouch acid and serum gastrin responses to feeding were determined in conscious cats before and after exclusion of the proximal small intestine. Exclusion did not change the secretory capacity and sensitivity of the oxyntic glands to pentagastrin. The acid and gastrin (components III and IV) responses to feeding were also unaltered. Duodenal gastrin is therefore of no significance for the postprandial acid response. Nevertheless, the duodenum is implicated in the postprandial acid secretion, since food in the duodenum releases a factor that augments the maximal acid response to exogenous gastrin. The unchanged postprandial acid response after exclusion implies that this factor is not localized exclusively in the proximal small intestine.

Antrum participates in the postprandial augmentation of the acid response to exogenous gastrin in conscious cats

“…T h a t the mechanism is situated in both Correspondence: Sverre Emis, M.D., Department of Surgery, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden. the stomach and duodenum was in agreement with the finding that duodenal exclusion did not change the maximal acid response to feeding in HP cats (Fernstrom et al 1982). T h e site of the gastrin-potentiating mechanism in the stomach is yet unknown.…”

“…Similar results have been reported after antrectomy in dogs (Keuppens et al 1976) and peptic ulcer patients (Saik et al 1977). In cats, meat in the duodenum did not alter serum gastrin concentration (Fernstrom et al 1984), and the gastrin response to oral feeding was not changed by exclusion of the proximal small intestine (Fernstrom et al 1982). The present finding that antrectomy and exclusion abolished the postprandial gastrin response therefore suggests that the response is of antral origin.…”

Gastric Acid Response to Pentagastrin and Gastrin-Releasing Peptide in Conscious Cats

“…The minimal interval between the tests was 2 weeks when blood was sam pled for gastrin determination, otherwise the interval was 2 days. The vagal denervation of the HP was tested with 2-deoxy-/)-glucosc [9]. Gastric juice from the GF and HP was collected in 15-min periods and acid output determined by automatic titration [9].…”

“…The vagal denervation of the HP was tested with 2-deoxy-/)-glucosc [9]. Gastric juice from the GF and HP was collected in 15-min periods and acid output determined by automatic titration [9]. Basal secretion was measured for at least 30 min and stimulated secretion for 1.5 h. Peak acid output (PAO) is the mean 15-min acid response during the peak half hour, independent of time.…”