Postprandial lipemia in men with metabolic syndrome, hypertensives and healthy subjects

Abstract

BackgroundThe metabolic syndrome (MetS), as well as postprandial hypertriglyceridemia, is associated with coronary heart disease. This study aimed to evaluate the postprandial lipemia after oral fat tolerance test (OFTT) in subjects with MetS and compare them to hypertensive (HTN) and healthy subjects.ResultsOFTT was given to 33 men with MetS (defined by the Adult Treatment Panel III), 17 HTN and 14 healthy men. The MetS group was further divided according to fasting triglycerides (TG) into TG ≥ 150 [MetS+TG, (n = 22)] or <150 mg/dl [MetS-TG (n = 11)], and into those with or without hypertension [MetS+HTN (n = 24), MetS-HTN (n = 9), respectively]. TG concentrations were measured before and at 4, 6 and 8 h after OFTT and the postprandial response was quantified using the area under the curve (AUC) for TG.The postprandial response was significantly higher in MetS compared to HTN and healthy men [AUC (SD) in mg/dl/h; 2534 ± 1016 vs. 1620 ± 494 and 1019 ± 280, respectively, p ≤ 0.001]. The TG levels were increased significantly in MetS+TG compared to MetS-TG subjects at 4 (p = 0.022), 6 (p < 0.001) and 8 hours (p < 0.001). The TG were increased significantly in MetS-TG compared to healthy subjects at 4 (p = 0.011), 6 (p = 0.001) and 8 hours (p = 0.015). In linear regression analysis only fasting TG levels were a significant predictor of the AUC (Coefficient B = 8.462, p < 0.001).ConclusionFasting TG concentration is the main determinant of postprandial lipemia. However, an exaggeration of TG postprandialy was found in normotriglyceridemic MetS and HTN compared to healthy subjects. This suggests that intervention to lower fasting TG levels should be recommended in MetS subjects.

Factors associated with postprandial lipemia and apolipoprotein A-V levels in individuals with familial combined hyperlipidemia

“…In contrast to our results, other studies including individuals with diverse cardiovascular risk have reported that fasting triglycerides levels is the major determinant of postprandial lipemia [ 3 , 5 , 6 , 20 ]. The novel finding of an independent association between fasting apo B-48 levels and postprandial lipemia in FCH indicate a potential role for intestinal-derived lipoproteins in postprandial metabolism in individuals with FCH.…”

The Effect of Statins on Postprandial Lipemia

“…The metabolic syndrome, a clustering of several abnormalities including fasting hypertriglyceridemia, is associated with abnormal postprandial lipemia [16,73,74]. In hypercholesterolemic patients with the metabolic syndrome, simvastatin and atorvastatin had comparable beneficial effects on apolipoprotein B-containing atherogenic lipids and lipoproteins, and metabolic syndrome status was effectively modified by both drugs.…”

The Influence of Erythropoietin (EPO T<b>&#x2192;</b>G) and α-Actinin-3 (ACTN3 R577X) Polymorphisms on Runners' Responses to the Dietary Ingestion of Antioxidant Supplementation Based on Pequi Oil (<b><i>Caryocar brasiliense</i></b> Camb.): A Before-After Study

“…Results obtained with the minimum sample size calculations corroborate this suggestion, since the supplementation with pequi capsules reduced the variability of the sample and, consequently, the required sample size. Other reports with lower or equal intervention times have also shown physiological effects, with significant changes in the used markers [51,52,53,54,55]. …”