Postprandial lipid and carbohydrate responses after the ingestion of a casein-enriched mixed meal

Westphal, Sabine; Kästner, Stephanie; Taneva, Elina; Leodolter, Andreas; Dierkes, Jutta; Luley, Claus

doi:10.1093/ajcn/80.2.284

Cited by 60 publications

(65 citation statements)

References 37 publications

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“…Although the amounts of carbohydrate (1 g/kg) and fat (0.38 g/kg) in the cookie used in the present study are similar to those in the glucose (1 g/kg)1OFTT cream (0.35 g/kg as fat) used in our earlier study (7), the cookie also contains a small amount of protein derived from butter and egg (0.11 g/kg). It was reported that postprandial lipidemia was reduced when protein (50 g sodium caseinate) was added to fat food (14); however, the rise of TG and RLP-TG in the present study was comparable to that observed in our previous study (7). This may be because the amount of protein administered in the present study was small.…”

Section: Discussioncontrasting

confidence: 54%

Effects of Aerobic Exercise on Postprandial Carbohydrate and Lipoprotein Metabolism Following Cookie Ingestion in Healthy Young Women

Hashimoto

Mizutani

Suzuki

et al. 2015

J Nutr Sci Vitaminol

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SummaryWe examined the acute effects of postprandial aerobic exercise on glucose and lipid metabolism following cookie ingestion. Fifteen healthy young women with a sedentary lifestyle, normal weight and apolipoprotein E3/3 participated. After a 12-h overnight fast, each subject ingested a cookie (1.53 g/kg, Meal Test C) and then performed two trials, one with postprandial exercise (E trial) and one without exercise (C trial), in a randomized crossover design. A single 30-min bout of walking exercise was performed 20 min after the cookie intake. Venous blood samples were drawn before (0 h) and 20 min and 1, 2, 4, and 6 h after cookie ingestion. The Dglucose concentration was not significantly different between the two trials, but the Dinsulin concentration at 1 h and the incremental area under the curve (IAUC) (0-2 h)-insulin in the E trial were significantly lower than in the C trial. The ratio of glucose/insulin at 1 h was significantly higher in the E trial than in the C trial. The DTG, DRLP-TG, DapoB48 and DRemL-C concentrations at 1 h in the E trial were significantly higher than in the C trial. The IAUC (0-2 h)-apoB48 in the E trial was significantly larger than in the C trial. Postprandial exercise showed an insulin-sparing effect following the cookie ingestion by increasing insulin sensitivity. However, postprandial exercise transiently stimulated the secretion of exogenous apoB48-containing lipoprotein during the early period, and no further effects were observed. These results suggest that postprandial aerobic exercise is effective for the promotion of postprandial carbohydrate metabolism, but not lipidemia.

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Section: Discussioncontrasting

confidence: 54%

Effects of Aerobic Exercise on Postprandial Carbohydrate and Lipoprotein Metabolism Following Cookie Ingestion in Healthy Young Women

Hashimoto

Mizutani

Suzuki

et al. 2015

J Nutr Sci Vitaminol

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“…14,15 Although, the milk protein casein per se did not modulate the postprandial triglyceride response in T2DM. 14 However, when whey protein, another milk protein, was added to a fat-rich meal it acutely reduces the postprandial triglyceride response in T2DM subjects compared with casein, cod and gluten.…”

Section: Introductionmentioning

confidence: 94%

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

et al. 2012

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BACKGROUND/OBJECTIVES: Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects. SUBJECTS/METHODS: A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100 g of butter and 45 g of carbohydrate in combination with 45 g of whey isolate (iso-meal), whey hydrolysate (hydromeal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially. RESULTS: We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso-and lac-meal in the chylomicron-rich fraction (P ¼ 0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro-and iso-meal produced a higher insulin response compared with the lac-and CGMP-meal (Po0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period. CONCLUSIONS: A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.

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“…Interestingly, it has been demonstrated that the addition of refined carbohydrates to a fat-rich meal increases PPL in T2DM (Brader et al, 2010). However, this observation could not be demonstrated in healthy subjects (Westphal et al, 2004;Lairon et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

“…Thus, the unfavorable effect of carbohydrate on PPL seen in T2DM can be reduced by adding casein to the meal (Westphal et al, 2004;Brader et al, 2010). However, casein added to a fat-rich meal without carbohydrate did not affect PPL compared with a fat-rich meal per se in T2DM (Brader et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

et al. 2011

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Background/Objectives: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. Subjects/Methods: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m -2 ) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. Results: We observed no statistically significant (P ¼ 0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P ¼ 0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins. Conclusion: We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

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Postprandial lipid and carbohydrate responses after the ingestion of a casein-enriched mixed meal

Abstract: Casein added to a fatty meal lowers free fatty acids markedly in the postprandial and postabsorption phases, probably via its insulinotropic activity. Postprandial lipemia is also moderately reduced.

Cited by 60 publications

References 37 publications

Effects of Aerobic Exercise on Postprandial Carbohydrate and Lipoprotein Metabolism Following Cookie Ingestion in Healthy Young Women

Effects of Aerobic Exercise on Postprandial Carbohydrate and Lipoprotein Metabolism Following Cookie Ingestion in Healthy Young Women

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

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