Postradiation ureteral obstruction: A reappraisal

Muram, David; Oxorn, Harry; Curry, Raymond H.; Drouin, P; Walters, Jack H.

doi:10.1016/0002-9378(81)90012-0

Cited by 36 publications

(32 citation statements)

References 8 publications

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“…Although some studies report that Streptococcus spp. have been isolated from patients with pyometra [5], none of the studies have shown Group B Streptococci as a cause of pyometra. S. agalactae, which is considered a commensal in the female genital tract, can also cause serious infections such as pyometra, as seen in present study.…”

Section: Discussionmentioning

confidence: 98%

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Streptococcus agalactiae causing pyometra in an elderly female with cervical cancer

Gupta

Das

Krishna

2012

J Infect Dev Ctries

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Streptococcus agalactiae is an important cause of invasive infections in neonates and is emerging as an important pathogen in elderly females. S. agalactiae is a commensal organism of the female genital tract; however, isolation from the uterine cavity suggests ascending infection of this organism caused by occlusion of the uterine cavity. We report a case of S. agalactiae causing pyometra in an elderly female with cervical cancer.

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Section: Discussionmentioning

confidence: 98%

“…It develops gradually and as it progresses the uterus can become enlarged [4]. In one study of pyometra in 18 mainly post-menopausal women (17/18) the most common organism isolated was the anaerobic bacterium, Bacteriodes fragilis [5]. Anaerobic bacteria were isolated from the uterine cavity of 10 out of 18 patients (56%) having pyometra.…”

Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae causing pyometra in an elderly female with cervical cancer

Gupta

Das

Krishna

2012

J Infect Dev Ctries

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“…It is well known that information about renal abnormalities can be obtained from bone scintigraphy because 99m TC-MDP is excreted through the kidneys to provide adequate visualization of the urinary tract [20]. These abnormalities have included absent renal activity, small or displaced kidneys, urinary obstruction, focal renal parenchymal abnormalities, unilateral decrease in renal function, and asymmetric uptake [10][11][12][13][14]. In addition, detailed views of bladder can be obtained.…”

Section: Discussionmentioning

confidence: 99%

“…Bone scintigraphy, so far, is still a useful examination for the clinical diagnosis, especially in evaluating and following up the status of cancer patients with suspicious bony metastasis. Many authors [10][11][12][13][14] found that there are a number of renal disorders detected while doing bone scintigraphy because 99m TC-MDP (is excreted through the kidneys to provide adequate visualization of the urinary tract. Furthermore, damage to the kidney is caused by chemotherapy and/ or radiation therapy when the kidneys are included in the radiation field [15].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Efficacy of Bone Tracer 99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent 99mTC-DMSA

Hanafy¹,

Hamed²,

Elshafai³

2015

J Nucl Med Radiat Ther

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This study was performed to evaluate the usefulness of bone tracer 99m TC-MDP in detecting renal disorders by imaging of renal cortex for patients with cortical defect and estimation of split renal function (SRF) as compared with renal cortical imaging agent 99m TC-DMSA. In this study 23 patients (6 males, 17 females) with range age of 16y -75y (mean 45.6y ± 17.4y), and a total of 46 studies (using both 99m TC-DMSA and 99m TC-MDP per patient for left and right kidneys) were performed for detecting renal disorders. Both studies were performed within 48 hours between each other. SRF was calculated in all cases from renal uptake of the tracers into the region of interest by using computer acquired data of gamma camera. For detecting renal cortex abnormalities, all cortical scars and defects scars seen on 99m Tc-DMSA scan were also detected by 99m Tc-MDP.The results showed that the non visualized kidney on 99m TC-DMSA scan was also non visualized on 99m TC-MDP. Also, there was a high correlation between SRF values obtained from 99m TC-MDP and 99m TC-DMSA, where (p>0.01, r= 0.93 for left kidney and r=0.0.92 for right kidney).The similar SRF values of 99m TC-MDP and 99m TC-DMSA allow to use of 99mTC-MDP tracers for detecting both of bone and renal abnormalities.

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“…The differentiation between benign and malignant ureteric obstruction is often not possible with radiological and endourological methods alone so that histological verification is required in some cases [11]. In patients with advanced malignant disease, extrinsic neoplastic uereteric compression is more likely than intrinsic radiogenic stenosis and the occurrence of ureteric obstruction within the first two years after radiotherapy is more likely to be indicative of tumor progression [23]. In contrast, the manifestation of ureteric obstruction 5 or more years after radiotherapy makes radiogenic stenosis as the underlying cause highly likely since 96% of all recurrences are diagnosed within the first 5 years [23].…”

Section: Discussionmentioning

confidence: 99%

Manifestation, Latency and Management of Late Urological Complications after Curative Radiotherapy for Cervical Carcinoma

Gellrich¹,

Hakenberg²,

Oehlschläger³

et al. 2003

Oncol Res Treat

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Background: Radiotherapy alone or in combination with radical hysterectomy remains a potentially curative treatment for cervical carcinoma. Late urological complications after curative radiotreatment are rare but often present difficult problems of management due to the progressive nature of radiogenic tissue damage. We reviewed all cases of radiogenic urologic complications after radiotherapy for cervical carcinoma treated at our institution over the past 10 years. Patients and Methods: In a retrospective analysis, out of all female patients treated for hydronephrosis (n = 543), 93 patients with hydronephrosis occurring after curative treatment for gynecological malignancies were identified. The most frequent cause was progressive disease (n = 55); 30 patients without recurrence had severe radiogenic urological complications (study population). Results: Out of 30 patients with a mean age of 44.9 years at the time of treatment for cervical cancer, 6 had undergone primary radiotherapy and 24 had received adjuvant radiotreatment after radical hysterectomy. The observed late urological complications were: distal ureteral stenoses (bilateral in 4 cases, unilateral in 15 cases), distal ureteral necrosis (n = 1), bilateral ureteral reflux (n = 3), vesico-vaginal fistulae (n = 5), vesico-intestinal fistula (n = 1), severe fibrotic bladder shrinkage (n = 6) and urethral stenosis (n = 2). Marked signs of radiogenic cystitis were observed in almost all patients. The mean latency time between radiotherapy and manifestation of severe radiogenic urological sequelae was 19.4 years (range 0.5–41.5). Primary treatment of urological complications consisted in temporary urinary diversion by percutaneous nephrostomies or insertion of internal ureteral stents. Permanent treatment for radiogenic ureteral stenosis in all patients with sufficient general health consisted of surgical or endourological urinary diversion or reconstruction. However, the majority of patients were managed by permanent endourological measures. Lower tract fistulae were treated by distal ureteral occlusion and diversion. Conclusions: Although severe late urological sequelae of curative radiotherapy for cercvical carcinoma are rare they represent major complications, result in considerable distress for the patient, and often present difficult therapeutic problems for the urologist. As these urological complications can have extremely long latency times, focussed follow-up for early detection may be advisable.

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Postradiation ureteral obstruction: A reappraisal

Cited by 36 publications

References 8 publications

Streptococcus agalactiae causing pyometra in an elderly female with cervical cancer

Streptococcus agalactiae causing pyometra in an elderly female with cervical cancer

Evaluating the Efficacy of Bone Tracer 99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent 99mTC-DMSA

Manifestation, Latency and Management of Late Urological Complications after Curative Radiotherapy for Cervical Carcinoma

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