Posttransfusion Hepatitis in Spain. A Prospective Study

Hernandez, J.M.; Piqueras, J.; Carrera, A.; Triginer, J.

doi:10.1159/000465314

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Monophasic hepatitis had a chronicity rate significantly lower than polyphasic (P < 0.05) and plateau hepatitis (P < 0.01). This interesting feature of transaminase elevations has been documented in other studies (5, 16,[25][26][27]. These data, however, do not support the premise that monophasic disease is less likely to pursue a chronic course.…”

Section: Discussionmentioning

confidence: 51%

“…Iwarson et al (28) reported a case of cirrhosis and chronic active hepatitis in a liver biopsy carried out 1 year from the date of diagnosis, and proved evidence for a rapid evolution of liver cirrhosis with this type of hepatitis. Realdi et al (17) biopsied the liver at 17,25,26,36, and 40 months after the onset of the disease in their five cases of cirrhosis secondary to non-A, non-B posttransfusion hepatitis. Berman et al (4) did not report the time at which biopsies were carried out, and Rakela & Redeker (14), who initially could not find cirrhosis of the liver, demonstrated histologic cirrhotic features in a postmortem specimen of a patient who died 42 months after the onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Posttransfusion non‐A, non‐B hepatitis. A prospective study

Bárcena

Suárez-García

Gil

et al. 1985

Liver

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ABSTRACT— We have prospectively studied the clinical data, prognostic factors and chronic liver sequelae in 68 patients who developed posttransfusion non‐A, non‐B hepatitis. The mean incubation period was 5.9 weeks with a range from 2.1 to 12 weeks; 63.5% of the patients were asymptomatic and 60.6% anicteric. The chronicity rate (elevated ALT values for a period of more than 6 months) was 67.6%. The chronicity rate of symptomatic hepatitis (95.5%) was significantly higher than that of asymptomatic hepatitis (54.5%) (P<0.01). Monophasic hepatitis, characterized by a rapid elevation in serum ALT followed by a rapid decline with no further fluctuations, had a chronicity rate (42.5%) significantly lower than polyphasic hepatitis (86.6%) (P<0.05) and plateau type hepatitis (94.4%) (P<0.01). Results of 35 liver biopsies carried out among 46 patients with elevated ALT after 6 months were as follows: chronic active hepatitis, 15 cases; prolonged acute hepatitis, 12 cases; chronic persistent hepatitis, 6 cases; posthepatitis liver changes, 1 case; and secondary hemosiderosis, 1 case.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Posttransfusion non‐A, non‐B hepatitis. A prospective study

Bárcena

Suárez-García

Gil

et al. 1985

Liver

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“…Viral hepatitis commonly occurs in the absence of ser ologic markers for such known hepatotropic agents as hep atitis A virus (HAV), hepatitis B virus (HBV), cytomegalo virus (CMV) and Epstein-Barr virus (EBV) [1][2][3][4]. This entity termed non-A, non-B hepatitis (NANB) accounts for more than 90% of transfusion-associated hepatitis cases worldwide [5,6].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Virus Antibodies in High-Risk Saudi Groups

Bahakim¹,

Bakir²,

Arif³

et al. 1991

Vox Sanguinis

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The recombinant-based enzyme immunoassay developed by Ortho Diagnostic System for the detection of antibodies of hepatitis C virus (HCV) was used to determine the extent of exposure to HCV in healthy Saudi subjects (500 males; 260 females) without liver disease and with no history of percutaneous exposure to blood and in Saudis who are considered at high risk for contracting the disease: hemophiliacs (28), thalassémies (78), hemodialysis patients with renal failure (65) and patients with sexually transmitted diseases (STD) (220). The results show that HCV is endemic in the Saudi population with an overall frequency of 5.3% in healthy Saudi adults which is at least 5 times higher than what has been reported from Western Europe and the United States. Seropositivity rate in the high-risk groups ranges from 15.9% in patients with STD to 78.6% in hemophiliacs. These data underscore the urgent need for routine anti-HCV screening of blood donations in order to reduce the frequency of postransfusion non-A, non-B hepatitis and its sequelae in the Saudi population.

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“…Chronic infection by NANB hepatitis virus may cause a variety of hepatic lesions. Chronic active hepatitis with or without cirrhosis is found in about 60% of patients with post-transfusional NANB hepatitis (2)(3)(4)(5)(6)(7)(8), while chronic persistent hepatitis was the lesion more frequently seen in a few patients who developed chronic liver disease following an episode of sporadic NANB acute hepatitis (3,8,9), suggesting that NANB liver disease is more severe when it develops following blood transfusion.…”

mentioning

confidence: 99%

Post‐transfusional vs. sporadic non‐A, non‐B chronic hepatitis. A clinico‐pathological and evolutive study

Jové

Sánchez-Tapias

Bruguera

et al. 1988

Liver

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ABSTRACT— The clinical, morphological and evolutive features of 60 patients with chronic hepatitis, presumably caused by non‐A, non‐B virus infection, have been retrospectively analyzed. In all the cases the disease began as an acute episode of viral hepatitis that was followed by persistently abnormal liver function tests. No patient had evidence of current or past hepatitis B virus infection and other known causes of chronic liver disease were excluded. Thirty patients had received blood transfusions in the recent past, five were drug addicts and the source of the infection was not identified in the remaining 25, in whom the disease was considered to be sporadic. Clinical or biochemical differences between patients with post‐transfusional and sporadic non‐A, non‐B chronic hepatitis were not observed, but liver histology showed a higher proportion of patients with chronic persistent hepatitis in the sporadic (72%) than in the transfusional group (53%). On follow‐up, sustained normalization of liver function tests was observed in 46% of the cases with sporadic hepatitis but only in 13% of the cases with post‐transfusion hepatitis. These observations suggest that non‐A, non‐B chronic hepatitis is more severe in patients with transfusion‐related infection than in sporadic cases.

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Posttransfusion Hepatitis in Spain. A Prospective Study

Cited by 4 publications

References 9 publications

Posttransfusion non‐A, non‐B hepatitis. A prospective study

Posttransfusion non‐A, non‐B hepatitis. A prospective study

Hepatitis C Virus Antibodies in High-Risk Saudi Groups

Post‐transfusional vs. sporadic non‐A, non‐B chronic hepatitis. A clinico‐pathological and evolutive study

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