Posttransfusion hepatitis in Toronto, Canada

Feinman, S.V.; Berris, B.; S, Bojarski

doi:10.1016/0016-5085(88)90505-7

Cited by 65 publications

(13 citation statements)

References 21 publications

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“…We meed to shed more light on the exact etiology of ALT elevation through a systematic prospective study to determine whether viral hepatitis (particularly early hepatitis C) might be an important contributing factor to ALT elevation. Since ALT is neither sensitive nor specific for viral hepatitis, and results in the elimination of a large number of otherwise healthy blood donors, particularly in our population, and has clearly not reduced the incidence of posttransfusion hepatitis in the era of anti-HCV testing, 12,13 we agree with the recent AABB recommendation that it should not be performed routinely in addition to anti-HCV testing.…”

Section: Discussionsupporting

confidence: 69%

Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

et al. 1998

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Section: Discussionsupporting

confidence: 69%

Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

et al. 1998

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“…Definite hepatitis was noted in 205 cases (10.3%) and probable hepatitis in 246 cases (12.4%). The incidence of posttransfusion hepatitis in the present study exceeded that reported in several previous studies [3,[12][13][14][20][21][22], as summarized in table 10. Abnormal ALT in 2 consecutive blood specimens was needed for the diagnosis of posttransfusion hepatitis in the studies of Al ter et al…”

Section: Risk Factors Of Donated Bloodcontrasting

confidence: 55%

Posttransfusion Hepatitis in Japan

Takano¹,

Omata²,

Ohto³

et al. 1992

Vox Sanguinis

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The incidence of posttransfusion hepatitis and the rate of chronicity were investigated in a program devised at our hospital in December, 1982. Out of 2,596 blood recipients between January, 1982, and December, 1987, 451 (22.7%) developed posttransfusion hepatitis. Seventy-seven patients out of 217 (35.3%) whose course was closely followed progressed to chronicity. The incidence of posttransfusion hepatitis increased with the volume of transfused blood without any evident limitation. Recipients of elevated-ALT donor blood (>26 Karmen units) were found to be more susceptible to posttransfusion hepatitis than those who had received only normal-ALT donor blood. Packed red blood cells, whole blood and fresh whole blood were high-risk components, and fresh frozen plasma a low-risk component of blood. The carrier rate of non-A, non-B hepatitis agents in Japanese healthy blood donors was determined to be 1.2% using the Frost-Reed model of infectious diseases. Anti-hepatitis C virus was detected in 62% of the cases of posttransfusion hepatitis 1 year after transfusion.

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“…The etiology' of impaired hepatic function fol lowing surgical treatment is frequently enigmatic, and the definition leading to a diagnosis is elusive. Therefore, we used the increase of GPT levels as an indicator of postop erative hepatic dysfunction, based on the definition of posttransfusion hepatitis [10,11]. The occurrence of post operative hepatic failure was minimal even in patients with postoperative hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the definition of posttransfusion hepatitis [10,11], a patient was considered to have postoperative liver dysfunction if the serum alanine aminotransferase (GPT) level rose to 2.5 times the upper limit of the normal value or more and if a second sample obtained about 7 days later was at least twice the upper limit of nor mal.…”

Section: Definition O F Hepatic Dysfunctionmentioning

confidence: 99%

Risk Factors for Postoperative Hepatic Dysfunction Determined by Multivariate Analysis

et al. 1993

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Risk factors for postoperative hepatic dysfunction were studied by measuring the change in the serum alanine aminotransferase (GPT). We studied 1,759 patients consecutively treated with surgery for various diseases of the lung, breast, esophagus, stomach, colon, rectum, liver, biliary tract, portal system and aorta in the Department of Surgery II, Kyushu University, Japan from 1985 to 1989. The multivariate analysis revealed that the independent risk factors for postoperative hepatic dysfunction were preexisting liver disease, surgical management of an esophageal cancer and halothane anesthesia.

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Posttransfusion hepatitis in Toronto, Canada

Cited by 65 publications

References 21 publications

Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

Posttransfusion Hepatitis in Japan

Risk Factors for Postoperative Hepatic Dysfunction Determined by Multivariate Analysis

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