2013
DOI: 10.1016/j.cub.2012.11.029
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Posttranslational Control of Cdc25 Degradation Terminates Drosophila’s Early Cell-Cycle Program

Abstract: SUMMARY In most metazoans, early embryonic development is characterized by rapid mitotic divisions that are controlled by maternal mRNAs and proteins that accumulate during oogenesis [1]. These rapid divisions pause at the Mid-Blastula Transition (MBT), coinciding with a dramatic increase in gene transcription and the degradation of a subset of maternal mRNAs [2, 3]. In Drosophila, the cell cycle pause is controlled by inhibitory phosphorylation of Cdk1, which in turn is driven by down-regulation of the activa… Show more

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Cited by 55 publications
(85 citation statements)
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“…Mutation of the consensus Chk1 phosphorylation sites in Twine does not affect its stability, demonstrating that String and Twine are not regulated the same way. 17 While this provides a satisfying mechanistic explanation of the regulation of the MBT in Drosophila, it is not clear why 2 Cdc25 factors are used in the early embryo, especially since Twine seems to be the key factor in timing G 2 at the MBT.…”
Section: The Midblastula Transition: Introducing Cell Cycle Complexitmentioning
confidence: 99%
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“…Mutation of the consensus Chk1 phosphorylation sites in Twine does not affect its stability, demonstrating that String and Twine are not regulated the same way. 17 While this provides a satisfying mechanistic explanation of the regulation of the MBT in Drosophila, it is not clear why 2 Cdc25 factors are used in the early embryo, especially since Twine seems to be the key factor in timing G 2 at the MBT.…”
Section: The Midblastula Transition: Introducing Cell Cycle Complexitmentioning
confidence: 99%
“…At each cell cycle the amount of DNA doubles, and at a set number of cycles, which differs among organisms, the embryo senses through a still unclear mechanism that a correct ratio has been reached, and this initiates the degradation of Twine. 17,18 But Twine degradation is only part of the story. The other Cdc25 ortholog, String, also must be degraded for the MBT to occur.…”
Section: The Midblastula Transition: Introducing Cell Cycle Complexitmentioning
confidence: 99%
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