Posttraumatic Deep Vein Thrombosis in Collegiate Athletes: An Exploration Clinical Case Series

Hummel, Chris; Geisler, Paul R.; Reynolds, Tim; Lazenby, Todd

doi:10.4085/1062-6050-362-16

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…As this is a fundamental aspect, we have not discussed this in detail in this study. However, platelet behavior may be influenced by general conditions such as physical trauma, strain, or injury, Platelet sensitivity to external stimuli may be higher in pro-athletes than in non-athletes as the former is more prone to develop venous thromboembolism [50,51]. During physical stress the sympathetic nervous system enters a state of dormancy, and circulating platelets are potentially exposed to adrenergic stimuli, leading to aggregation and activation with an increased release of stored growth factors [52][53][54].…”

Section: Growth Factors and Pf4 Storage In Platelet α-Granulesmentioning

confidence: 99%

The levels of TGFβ1, VEGF, PDGF-BB, and PF4 in platelet-rich plasma of professional soccer players: a cross-sectional pilot study

et al. 2022

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Background Regenerative therapy using platelet-rich plasma (PRP), a rich source of growth factors, has become popular in orthopedic sports medicine. Elite athletes prefer PRP therapy for their injured muscles and tendons primarily to avoid the possible risks of surgical treatment. However, the clinical effectiveness of PRP therapy in elite athletes compared to that in non-athletes remains unknown. Therefore, to investigate the effectiveness of PRP therapy in professional athletes (pro-athletes), we focused on the quality of PRP preparations and compared the levels of bioactive molecules between pro-athletes and non-athletes. Methods PRP was prepared from healthy, non-smoking male professional soccer players (pro-athletes) (n = 22) and non-athletes (VEGF: n = 34, others: n = 38). The levels of TGFβ1, PDGF-BB, VEGF, and PF4 were determined using ELISA kits. Polyphosphate was probed with 4’,6-diamidino-2-phenylindole and monitored using a fluorometer. The body composition of the donors was determined using a bathroom weighing scale. Results The levels of TGFβ1 and VEGF were significantly lower in pro-athletes than in non-athletes, whereas PF4 levels were significantly higher in pro-athletes. No significant difference was found in PDGF-BB levels between these groups. Biomolecule levels were not correlated with polyphosphate levels. Conclusion TGFβ1, VEGF, and PDGF-BB levels in pro-athletes were not higher than those in non-athletes. These findings suggest that growth factor levels in PRP may not be a predominant determinant of the clinical effectiveness of PRP therapy in pro-athletes. Increased PF4 levels in pro-athletes suggest an immunological function of PRP that may positively influence tissue regeneration.

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Section: Growth Factors and Pf4 Storage In Platelet α-Granulesmentioning

confidence: 99%

The levels of TGFβ1, VEGF, PDGF-BB, and PF4 in platelet-rich plasma of professional soccer players: a cross-sectional pilot study

et al. 2022

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“… 1 Although physical immobility has been described as a risk factor for DVT, some studies have suggested that competitive athletes could also have a high risk of DVT. 14 , 15 , 16 More recent studies have suggested that COVID-19 exposure might play a role in DVT formation in critically ill patients. 17 …”

Section: Discussionmentioning

confidence: 99%

A unique case of acute bilateral internal iliac deep vein thrombosis leading to right iliofemoral venous outflow obstruction

Melian

Giannopoulos²,

Lee³

et al. 2023

Journal of Vascular Surgery Cases, Innovations and Techniques

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“…The most common among them are dehydration, intense effort and trauma or injury (Fig. 2) [42]. Dehydration occurs during intense physical activity and makes the blood more likely to form clots [43,44,45].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Thrombogenic Risk Factors in Young Adult Male Sportsmen Members of a Rowing Club in Bydgoszcz.

Wysocki,

Koszarska,

Bartel

et al. 2023

Preprint

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Background Athletes represent one of the population groups at risk of thrombosis. Microtraumas and dehydration resulting from intense physical activity represent some of the important causes of thrombosis among athletes. Both blood clotting parameters (PT, INR, APTT, Fb, TT) and tissue damage parameters (H-FABP, L-FABP) are used to monitor thrombosis risks. Aim The aim of the study was to check the impact of sportsmen's physical activity on blood coagulation processes and myocardial microinjuries in young adult male sportsmen members (18–25 years old) of a rowing club in Bydgoszcz. Results Comparing the results of athletes before and after 6 months of training season, a statistically significant increase in the following parameters: PT (12.03 ± 0.76 vs. 13.51 ± 0.72 s; p < 0.01), INR (1.03 ± 0.07 vs. 1.14 ± 0.06; p < 0.01), APPT (28.73 ± 3.27 vs. 33.31 ± 5.63 s; p < 0.01) and TT (20.62 ± 0.97 vs. 22.49 ± 1.41 s; p < 0.01) was observed. Analyzing the results between the control group (non-sportsmen) and the study group before training, the following changes were observed: APTT (35.26 ± 6.74 vs. 28.73 ± 3.27 s; p < 0.01), HGMCR (750.17 ± 59.23 vs. 569.38 ± 51.24 ng/L; p < 0.01) and L-FABP (329.16 ± 92.04 vs. 151.80 ± 70.10 ng/L; p = 0.02) and an increase in H-FABP level (2.75 ± 1.32 vs. 4.14 ± 1.30 ng/mL; p < 0.01). Comparing the values between the control group and the study group, but after training, an increase in the value for PT (12.88 ± 1.41 vs. 13.51 ± 0.72 s; p = 0.02), INR (1.09 ± 0.13 vs. 1.14 ± 0.06; p = 0.02), TT (20.64 ± 1.43 vs. 22.49 ± 1.41 s; p < 0.01) and H-FABP (2.75 ± 1.32 vs. 3.94 ± 1.47 ng/L; p < 0.01) and decrease in HGMCR activity (750.17 ± 59.23 vs. 581.47 ± 51.25 ng/L; p < 0.01) were observed. There was also a strong positive correlation between HGMCR and H-FABP (r = 0.77) and a strong negative correlation between TT and Fb (r = -0.808) and between TT and APTT (r = -0.424). Conclusions Summarizing our study, we confirm that the physical activity in sportsmen, especially overtraining, may have an impact on blood coagulation processes and may also lead to the microdamage of the heart muscle.

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Posttraumatic Deep Vein Thrombosis in Collegiate Athletes: An Exploration Clinical Case Series

Cited by 10 publications

References 13 publications

The levels of TGFβ1, VEGF, PDGF-BB, and PF4 in platelet-rich plasma of professional soccer players: a cross-sectional pilot study

The levels of TGFβ1, VEGF, PDGF-BB, and PF4 in platelet-rich plasma of professional soccer players: a cross-sectional pilot study

A unique case of acute bilateral internal iliac deep vein thrombosis leading to right iliofemoral venous outflow obstruction

Investigation of Thrombogenic Risk Factors in Young Adult Male Sportsmen Members of a Rowing Club in Bydgoszcz.

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