Posttraumatic stress as a contributor to behavioral health outcomes and healthcare utilization in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Crochet, Emily; Tyc, Vida L.; Wang, Mingjuan; Srivastava, Deo Kumar; Sickle, Kristi Van; Nathan, Paul C.; Leisenring, Wendy; Gibson, Todd M.; Armstrong, Gregory T.; Krull, Kevin R.

doi:10.1007/s11764-019-00822-5

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…Following diagnosis, immense disruption to the life of patients may also occur, with interruption to schooling, loss of employment and reduced social interactions [6,[9][10][11]. PYACPs, thus, suffer disproportionately not only from physical complications related to cancer and its treatment [12], but from psychological symptoms and disorders as a result [13].…”

Section: Introductionmentioning

confidence: 99%

Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Lee

Yau

Low

et al. 2023

JCM

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Background: A diagnosis of cancer and treatment may constitute a highly traumatic period for paediatric cancer patients (PYACPs). However, no review has comprehensively analysed how the mental health of PYACPs is acutely affected and the longitudinal course. Methods: This systematic review followed PRISMA guidelines. Comprehensive searches of databases were conducted to identify studies of depression, anxiety and post-traumatic stress symptoms in PYACPs. Random effects meta-analyses were used for the primary analysis. Results: From 4898 records, 13 studies were included. Acutely after diagnosis, depressive and anxiety symptoms were significantly elevated in PYACPs. Depressive symptoms only significantly decreased after 12 months (standardised mean difference, SMD = −0.88; 95% CI: −0.92, −0.84). This downward trajectory persisted to 18 months (SMD = −1.862; 95% CI: −1.29, −1.09). Anxiety symptoms similarly only decreased after 12 (SMD = −0.34; 95% CI: −0.42, −0.27) up to 18 months (SMD = −0.49; 95% CI: −0.60, −0.39) after the cancer diagnosis. Post-traumatic stress symptoms showed protracted elevations throughout follow-up. Overall, significant predictors of poorer psychological outcomes included unhealthy family functioning, concomitant depression or anxiety, poor cancer prognosis or experiencing cancer and treatment-related side effects. Conclusions: While depression and anxiety may improve over time with a favourable environment, post-traumatic stress may have a protracted course. Timely identification and psycho-oncological intervention are critical.

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Section: Introductionmentioning

confidence: 99%

Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Lee

Yau

Low

et al. 2023

JCM

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“…Depression and anxiety are known to negatively impact certain neurocognitive domains. Data is conflicting whether pediatric survivors are at higher risk of depression, anxiety or posttraumatic stress disorder, although posttraumatic stress symptoms are common [ 73 , 74 ]. A recent study from the Childhood Cancer Survivor Study identified a positive role of exercise in adult survivors of childhood cancer.…”

Section: Immune- or Cellular-mediated Neurotoxicity After Hct And Ctmentioning

confidence: 99%

Monitoring Neurocognitive Functioning After Pediatric Cellular Therapy or Hematopoietic Cell Transplant: Guidelines From the COG Neurocognition in Cellular Therapies Task Force

Schofield¹,

Fabrizio²,

Braniecki³

et al. 2022

Transplantation and Cellular Therapy

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“…Childhood cancer survivors also face social and economic disadvantages in life as they are less likely to graduate college and less likely to have full-time employment [ 178 , 179 ]. Almost 15% of childhood cancer survivors develop posttraumatic stress symptoms that can impede quality of life [ 180 ]. Many of these risks differ based on the primary malignancy, however the treatment modalities employed during childhood also confer risk of developing these outcomes in adulthood.…”

Section: Long-term Outcomesmentioning

confidence: 99%

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

Castle

Levy

Chauhan

2022

Cancers

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Neuroendocrine neoplasms (NENs) encompass a variety of neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) which can arise anywhere in the body. While relatively rare in the pediatric population, the incidence of NENs has increased in the past few decades. These neoplasms can be devastating if not diagnosed and treated early, however, symptoms are variable and can be indolent for many years. There is a reported median of 10 years from the appearance of the first symptoms to time of diagnosis. Considering some of these neoplasms have a mortality rate as high as 90%, it is crucial healthcare providers are aware of NENs and remain vigilant. With better provider education and easily accessible resources for information about these neoplasms, awareness can be improved leading to earlier disease recognition and diagnosis. This manuscript aims to provide an overview of both the most common NENs as well as the rarer NENs with high lethality in the pediatric population. This review provides up to date evidence and recommendations, encompassing recent changes in classification and advances in treatment modalities, including recently completed and ongoing clinical trials.

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Posttraumatic stress as a contributor to behavioral health outcomes and healthcare utilization in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Cited by 11 publications

References 27 publications

Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Monitoring Neurocognitive Functioning After Pediatric Cellular Therapy or Hematopoietic Cell Transplant: Guidelines From the COG Neurocognition in Cellular Therapies Task Force

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

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