Posttraumatic stress disorder diagnosis is associated with reduced parasympathetic activity during sleep in US veterans and military service members of the Iraq and Afghanistan wars

Ulmer, Christi S.; Hall, Martica; Dennis, Paul A.; Beckham, Jean C.; Germain, Anne

doi:10.1093/sleep/zsy174

Cited by 42 publications

(31 citation statements)

References 51 publications

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“…Generally, HRmin declines throughout sleep and appears when the parasympathetic is reaching its maximal activity relative to the autonomic nervous system. [35,36]. These results could be used to explain the vagal tone improvement elicited by ETP, which was consistent with the progressive rise in cardiac parasympathetic activity.…”

Section: Plos Onesupporting

confidence: 73%

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

et al. 2020

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The dogs' responses to training exercise are seldom monitored using physiological variables, and cardiac autonomic regulation (CAR) is a relevant determinant of endurance-training adaptation. There are studies in the literature establishing that regular exercise could interfere with CAR in dogs, measured by heart rate and vagal-derived indexes of heart-ratevariability (HRV). However, few studies were found using a prescribed training program based on the lactate threshold (LT) to determine HRV by a 24-h Holter analysis. The purpose of this study was to test whether an endurance-training program (ETP) guided individually by LT raises time-domain measures of HRV in healthy Beagle dogs. Twenty dogs were assigned to two groups: control (C) and trained (T). The dogs from group T underwent an incremental exercise test (IET) to determine their LT. Both LT and velocity corresponding to the LT (VLT) was determined by visual inspection. T group performed an eight-week endurance-training program consisting of treadmill runs set to 70-80% of the VLT. Next, dogs from the group T have submitted to IET again. The maximal velocities (Vmax) at which achieved by the trained dogs in both IETs were determined. The group S did not undergo IETs or ETP. HRV was determined by the 24-hour-Holter at rest, before and on the 2˚, 4˚, 6å nd 8˚training weeks. To examine the HR impact on HRV, standard HRV variables were normalized to prevailing HR. VLT and Vmax rose in group T, indicating an improvement of dogs' aerobic and anaerobic capacity. The normalized standard HRV indexes were relatively attenuated since these variables had a reduction in the degree of correlation concerning an average HR. The ETP resulted in decreased resting heart rate and increased timedomain indices, highlighting the log-transformed square root of the mean sum of the

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Section: Plos Onesupporting

confidence: 73%

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

et al. 2020

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“…Their band lie in the 95% of the total power of the HRV power in a 24-h recording (Fisher et al, 2014). VLF power is strongly associated with all-cause mortality (Tsuji et al, 1994;Hadase et al, 2004;Schmidt et al, 2005), post-traumatic stress disorder (PTSD) (Ulmer et al, 2018), and emotional stress (Fisher et al, 2014). Parasympathetic nervous system activity was found to contribute VLF power mainly (Berntson et al, 1997;Taylor et al, 1998).…”

Section: Discussionmentioning

confidence: 97%

Association Between Postoperative Long-Term Heart Rate Variability and Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Prospective Cohort Study

Sun

Zhang

Lin

et al. 2021

Front. Aging Neurosci.

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BackgroundPostoperative delirium (POD) is a common complication after orthopedic surgery in elderly patients. The elderly may experience drastic changes in autonomic nervous system (ANS) activity and circadian rhythm disorders after surgery. Therefore, we intend to explore the relationship between postoperative long-term heart rate (HR) variability (HRV), as a measure of ANS activity and circadian rhythm, and occurrence of POD in elderly patients.MethodsThe study population of this cohort was elderly patients over 60 years of age who scheduled for orthopedic surgery under spinal anesthesia. Patients were screened for inclusion and exclusion criteria before surgery. Then, participants were invited to wear a Holter monitor on the first postoperative day to collect 24-h electrocardiographic (ECG) data. Parameters in the time domain [the standard deviation of the normal-to-normal (NN) intervals (SDNN), mean of the standard deviations of all the NN intervals for each 5-min segment of a 24-h HRV recording (SDNNI), and the root mean square of successive differences of the NN intervals (RMSSD)] and frequency domain [heart rate (HR), high frequency (HF), low frequency (LF), very low frequency (VLF), ultra low frequency (ULF), and total power (TP)] were calculated. Assessment of delirium was performed daily up to the seventh postoperative day using the Chinese version of the 3-Min Diagnostic Interview for CAM-defined Delirium (3D-CAM). The relationship between HRV and POD, as well as the association between HRV and duration of POD, was assessed.ResultsOf the 294 cases that finally completed the follow-up, 60 cases developed POD. Among the HRV parameters, SDNNI, VLF, and ULF were related to the occurrence of POD. After adjustment for potential confounders, the correlation between HRV indices and POD disappeared. Through stratified analysis, two significant negative correlations emerged: ULF in young-old participants and SDNNI, VLF, and ULF in male patients.ConclusionThe lower HRV parameters may be related to the occurrence of POD, and this correlation is more significant in young-old and male patients. ANS disorders and rhythm abnormalities reflected by HRV changes may represent a possible mechanism that promotes POD.

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“…Vanoli et al, found that sleep HRV was highly relevant to the identification of autonomic derangements which may account for a higher risk of lethal events after myocardial infarction [29]. Recently, reduced parasympathetic modulation during sleep been reflected by the high frequency component of HRV was reported to be one potential mechanism underlying the increased prevalence of CVD among veterans with posttraumatic stress disorder [30]. Although the association between HRV and CVD has been well recognized, it is still largely unknown that whether HRV features, especially during sleep, can assist the prediction of the occurrence of CVD events after years of latency.…”

Section: Introductionmentioning

confidence: 99%

Sleep heart rate variability assists the automatic prediction of long-term cardiovascular outcomes

Zhang

et al. 2020

Sleep Medicine

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Objective: We aimed to investigate the association between sleep HRV and long-term cardiovascular disease (CVD) outcomes, and further explore whether HRV features can assist the automatic CVD prediction. Methods: We retrospectively analyzed polysomnography (PSG) data obtained from 2111 participants in the Sleep Heart Health Study, who were followed up for a median of 11.8 years after PSG acquisition. During follow-up, 1252 participants suffered CVD events (CVD group) and 859 participants remained CVD-free (non-CVD group). HRV measures, derived from time-domain and frequency-domain, were calculated. Regression models were created to determine the independent predictor for long-term CVD outcomes, and to explore the association between HRV and CVD latency. Furthermore, based on HRV and other clinical features, a model was trained to automatically predict CVD outcomes using the eXtreme Gradient Boosting algorithm. Results: Compared with the non-CVD group, decreased HRV during sleep was found in the CVD group. HRV, particularly its component of high frequency (HF), was demonstrated to be independent predictor of CVD outcomes. Moreover, normalized HF was positively correlated with *

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Posttraumatic stress disorder diagnosis is associated with reduced parasympathetic activity during sleep in US veterans and military service members of the Iraq and Afghanistan wars

Abstract: The research described herein was conducted at the University of Pittsburgh.

Cited by 42 publications

References 51 publications

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

Effect of a lactate‐guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs

Association Between Postoperative Long-Term Heart Rate Variability and Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Prospective Cohort Study

Sleep heart rate variability assists the automatic prediction of long-term cardiovascular outcomes

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