Purpose: This case report describes the identification and treatment of costochondritis with suspected neural entrapment in a 14-year-old individual diagnosed with cystic fibrosis. Summary of Key Points: The individual discussed in this report had resolution of his chest pain with additional improvement in pulmonary function test results. Statement of Conclusion and Recommendations for Clinical Practice: This case supports the need for musculoskeletal and neuromuscular screening and intervention for patients with cystic fibrosis. The success of the intervention suggests that when traditional approaches to treatment of costochondritis fail, use of myofascial release at the accessory muscles of breathing could be beneficial.