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(CMV) in the pulmonary tissue ofpatients with AIDS8 and human herpes virus 6 associated interstitial pneumonitis in bone marrow transplant patients.9 Although a number of features of this suggest that EBV may be pathogenic, it is important to note that, because of the presence of immunosuppression, it remains possible that the EBV replication was coincidental rather than causal to the graft failure.The histological features of the open lung biopsy specimen suggest that neither obliterative bronchiolitis nor bronchiolitis obliterans organising pneumonia were the cause of the graft failure. The presence of pyrexia in association with an eosinophilic infiltrate, and the demonstration of EBV replication which responded to ganciclovir, implicates EBV in the aetiology of the graft failure. In view of this case and recent reports documenting EBV within lung graft tissue,'0 EBV may be an important occult pathogen in the setting of lung graft failure.

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