Pot-bellied pig neoplasia

Newman, Shelley J.; Rohrbach, Barton W

doi:10.1177/1040638712452725

Cited by 25 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mast cell neoplasia in pigs is rarely reported and can range from well differentiated, benign lesions to malignant and metastatic cancer (Bundza & Dukes, 1982;Newman & Rohrbach, 2012). In one study, multiple cutaneous and visceral MCTs were reported in three pigs, two of which were simultaneously diagnosed with eperythrozoonosis (Bundza & Dukes, 1982).…”

Section: Pig (Sus Scrofa Domesticus)mentioning

confidence: 99%

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Tamlin

Bottema

Peaston

2019

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain KIT mutations are associated with more malignant and lethal disease. In contrast, KIT mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. KIT genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within KIT are classified as either regulatory‐type or enzymatic pocket‐type mutations according to their location within the KIT Proto‐Oncogene. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour KIT mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of KIT in the canine and feline forms in comparison to human mast cell neoplasia.

show abstract

Section: Pig (Sus Scrofa Domesticus)mentioning

confidence: 99%

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Tamlin

Bottema

Peaston

2019

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…On the other hand, Vietnamese potbellied minipigs raised as companion animals do reach old ages. Indeed, a retrospective study found a variety of neoplasms with widespread metastases in these pigs of advanced age (~11 years; Newman and Rohrbach, 2012 ). The most common malignances found included hepatic and intestinal carcinomas, and uterine and ovarian smooth muscle tumors ( Newman and Rohrbach, 2012 ).…”

Section: Use Of Pigs In Biomedical Researchmentioning

confidence: 99%

Efficacy of the porcine species in biomedical research

et al. 2015

View full text Add to dashboard Cite

Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they have been used in biomedical research, given they share many physiological and anatomical similarities with humans. Recent technological advances in assisted reproduction, somatic cell cloning, stem cell culture, genome editing, and transgenesis now enable the creation of unique porcine models of human diseases. Here, we highlight the potential applications and advantages of using pigs, particularly minipigs, as indispensable large animal models in fundamental and clinical research, including the development of therapeutics for inherited and chronic disorders, and cancers.

show abstract

“…Cutaneous mast cell tumors have been reported in pigs 6 months to 3 years of age, and there are no breed or sex predilections 3 . Other literature reported the mean age of Pot‐bellied pigs with neoplasia was 11.3 years, confirming that neoplasia is often a disease of geriatric animals 4 . Hepatic and intestinal carcinomas have been documented to be the predominating malignancies found in Pot‐bellied pigs 4 .…”

Section: Discussionmentioning

confidence: 88%

“…4 Hepatic and intestinal carcinomas have been documented to be the predominating malignancies found in Pot-bellied pigs. 4 In domestic animals, mastocytomas (mast-cell tumors) are found most frequently in dogs, less frequently in cats and cattle, and rarely in horses and pigs. 5 There are few reports describing mast cell proliferation in pigs, and the majority refer to systemic mastocytosis with associated cutaneous tumors; more rarely, spontaneous neoplastic proliferations confined to the skin have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Other literature reported the mean age of Pot‐bellied pigs with neoplasia was 11.3 years, confirming that neoplasia is often a disease of geriatric animals 4 . Hepatic and intestinal carcinomas have been documented to be the predominating malignancies found in Pot‐bellied pigs 4 . In domestic animals, mastocytomas (mast‐cell tumors) are found most frequently in dogs, less frequently in cats and cattle, and rarely in horses and pigs 5 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pot‐bellied Vietnamese pig with visceral mast cell tumors and mastocytemia

Willey

Baughman

Beam

et al. 2022

Veterinary Clinical Pathol

View full text Add to dashboard Cite

An approximately 12‐year‐old female Vietnamese Pot‐Bellied Pig was presented to the Mississippi State College of Veterinary Medicine Food Animal Service for anorexia of 2 days duration. On physical examination, the patient appeared depressed and lethargic with significantly pale mucus membranes, open mouth breathing, and nostril flaring. On abdominal palpation, the abdomen was tense and uncomfortable. A complete blood count (CBC) and chemistry profile were performed. The CBC revealed significant anemia and mild leukocytosis characterized by mild neutrophilia with a left shift. Mast cells were rarely observed. Hematocrit = 8.1% (RI 22‐50), RBC = 1.25 × 106/μL (RI 3.6‐7.8), WBC = 19.85 × 103/μL (RI 5.2‐17.9), Neutrophils = 15.08 × 103/μL (RI 0‐11.4), and Bands = 0.993 × 103/μL (RI 0‐0.019). The chemistry profile was unremarkable with a mildly elevated BUN and slightly decreased total protein and albumin (BUN = 39 mg/dL [RI 4.2‐15.1], total protein = 6.2 g/dL [RI 6.6‐8.9], and albumin = 2.5 g/dL [RI 3.6‐5.0]). An abdominal ultrasound revealed numerous hypoechoic nodules diffusely scattered throughout the hepatic parenchyma. An FNA of one of the hepatic nodules was performed. A mild suppurative component and numerous variably granulated mast cells were observed. A presumptive cytologic diagnosis of mast cell tumor was made. Histopathology was performed, confirming the cytologic interpretation.

show abstract

Pot-bellied pig neoplasia

Cited by 25 publications

References 16 publications

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment

Efficacy of the porcine species in biomedical research

Pot‐bellied Vietnamese pig with visceral mast cell tumors and mastocytemia

Contact Info

Product

Resources

About