Potamogetonin, a new furanoid diterpene.  Structural assignment by carbon-13 and proton magnetic resonance

Smith, C. R.; Madrigal, R. V.; Weisleder, David; Mikolajczak, K. L.; Highet, R. J.

doi:10.1021/jo00866a002

Cited by 18 publications

(15 citation statements)

References 2 publications

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“…(1996) found that culture filtrates from E. densa inhibited the growth of Selenastrum capricornutum Printz and Microcystis aeruginosa Kütz. Smith et al. (1976) isolated a furanoid diterpene from P. illinoensis, which was found to possess algicidal properties (DellaGreca et al.…”

Section: Discussionmentioning

confidence: 99%

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Biological control of phytoplankton by the subtropical submerged macrophytes Egeria densa and Potamogeton illinoensis: a mesocosm study

Vanderstukken¹,

Mazzeo

Colen³

et al. 2011

Freshwater Biology

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1. In temperate regions, submerged macrophytes can hamper phytoplankton blooms. Such an effect could arise directly, for instance via allelopathy, or indirectly, via competition for nutrients or the positive interaction between submerged macrophytes and zooplankton grazing. However, there is some evidence that the positive interaction between submerged macrophytes and zooplankton grazing is less marked in warmer regions, where the interaction is less well studied, and that negative effects of higher water plants on phytoplankton biomass are weaker. 2. We carried out two consecutive mesocosm experiments in Uruguay (subtropical South America) to study the effects of two common submerged macrophytes from this region (Egeria densa and Potamogeton illinoensis) on phytoplankton biomass, in the absence of zooplankton grazing. We compared phytoplankton development between different macrophyte treatments (no macrophytes, artificial macrophytes, real Egeria and real Potamogeton). We used artificial macrophytes to differentiate between physical effects (i.e. shading, sedimentation and competition with periphyton) and biological effects (i.e. nutrient competition and allelopathy). 3. In Experiment 1, we found no evidence for physical effects of macrophytes on phytoplankton biomass, but both macrophyte species seemed to exert strong biological effects on phytoplankton biomass. Only Egeria affected phytoplankton community structure, particularly tempering the dominance of Scenedesmus. Nutrient addition assays revealed that only Egeria suppressed phytoplankton through nutrient competition. 4. We performed a second mesocosm experiment with the same design, but applying saturating nutrient conditions as a way of excluding the effects of competition for nutrients. This experiment showed that both macrophytes were still able to suppress phytoplankton through biological mechanisms, providing evidence for allelopathic effects.Our results indicate that both common macrophytes are able to keep phytoplankton biomass low, even in the absence of zooplankton grazing.

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Section: Discussionmentioning

confidence: 99%

“…There are indications that a few species common in the subtropics are allelopathic towards phytoplankton (e.g. Potamogeton illinoensis Hagstr., Smith et al. , 1976; DellaGreca et al.…”

Section: Introductionmentioning

confidence: 99%

Biological control of phytoplankton by the subtropical submerged macrophytes Egeria densa and Potamogeton illinoensis: a mesocosm study

Vanderstukken¹,

Mazzeo

Colen³

et al. 2011

Freshwater Biology

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“…2) are promising RT inhibitors 32–35. For example, kaurane and its derivatives have demonstrated very potent inhibition to RT32–34 by inhibiting the RT enzyme and stopping viral growth 36. Because of the similarity between kaurane and other diterpenoids, it is possible that they should have similar inhibition characteristics.…”

Section: Introductionmentioning

confidence: 99%

Docking of non‐nucleoside inhibitors: Neotripterifordin and its derivatives to HIV‐1 reverse transcriptase

2002

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The docking of small molecules to proteins has played an important role in the understanding of drug/receptor interactions. An important drug/receptor interaction is between non-nucleoside inhibitors of HIV-1 RT and the non-nucleoside binding pocket. We report the results of docking calculations in which we have docked known and proposed non-nucleoside reverse transcriptase inhibitors to the type 1 virus. The proposed NNRTIs dock in a similar position and orientation as known inhibitors. In addition, we observe a linear correlation between the calculated interaction energy and EC50 for the inhibitors, suggesting that the docked structure orientation and the interaction energies are reasonable. Two hydrogen bonds between nevirapine and RT (3HVT and 1VRT) are observed and are reproduced across different docking schemes. Since we used two different HIV-1 RT crystal structures (3HVT and 1VRT), which are at different levels of resolution (2.9 and 2.2 A, respectively), we propose that structures with resolutions better than 3 A can be used to produce reasonable docking results.

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“…In the Ayurvedic system, P. nodosus has been reported to be effective in treating cancer, tuberculosis, acne, and cough . Previous chemical investigations on different species of Potamogeton have shown the presence of alkaloids, , flavonoids, , and a labdane diterpenoid . As a part of our continuing studies on medicinal plants of Bangladesh, we have examined P. nodosus and isolated a furanoid labdane diterpene ( 1 ).…”

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confidence: 99%

A Furanoid Labdane Diterpene from Potamogeton nodosus

et al. 1998

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Potamogetonin, a new furanoid diterpene. Structural assignment by carbon-13 and proton magnetic resonance

Cited by 18 publications

References 2 publications

Biological control of phytoplankton by the subtropical submerged macrophytes Egeria densa and Potamogeton illinoensis: a mesocosm study

Biological control of phytoplankton by the subtropical submerged macrophytes Egeria densa and Potamogeton illinoensis: a mesocosm study

Docking of non‐nucleoside inhibitors: Neotripterifordin and its derivatives to HIV‐1 reverse transcriptase

A Furanoid Labdane Diterpene from Potamogeton nodosus

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