Potassium permanganate–acridine yellow chemiluminescence system for the determination of fluvoxamine, isoniazid and ceftriaxone

Abstract

Based on the oxidation of acridine yellow by permanganate in basic medium, a new chemiluminescence system was developed for the sensitive determination of some important drugs. The remarkable inhibiting effect of fluvoxamine, ceftriaxone and isoniazid on this reaction was applied to their detection. A possible mechanism was proposed for this system based on chemiluminescence emission wavelengths and experimental observations. Under optimum conditions, calibration graphs were obtained for 1 × 10(-9) to 1 × 10(-6) mol/L of fluvoxamine; 2 × 10(-8) to 8 × 10(-6) mol/L of ceftriaxone and 5 × 10(-8) to 4 × 10(-5) mol/L of isoniazid. This proposed method was satisfactorily used in the determination of these drugs in pharmaceutical samples and human urine and serum.

Enhanced chemiluminescence for trazodone trace analysis based on acidic permanganate oxidation in concurrent presence of rhodamine 6G

“…The powder was divided into three aliquots, each of which was then dissolved in water in an ultrasonic bath. Subsequently, the solutions were filtered to remove the insoluble fractions and then diluted to 100 mL …”

“…Subsequently, the solutions were filtered to remove the insoluble fractions and then diluted to 100 mL. [23] All serum samples were pretreated to remove any proteins that could interfere with the assay. This pretreatment consisted of mixing acetonitrile (250 μL), trazodone solution (500 μL), and serum (500 μL).…”

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

“…INZ, also known as isonicotinylhydrazide, is an effective antibiotic for latent and active tuberculosis infections. Several classical analytical methods have been developed for its determination, including chemical and spectroscopic methods, such as titrimetry , spectrophotometry , high performance liquid chromatography (HPLC) and chemiluminescence , while electroanalytical techniques are of particular advantage, due to their practicality, simplicity, low‐cost, adequate sensitivity, precision and speediness for real‐time detection.…”

Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

“…In this context, there is a strong need for extensive analysis of anti-TB drugs, being essential to design and develop a portable, sensitive and reliable sensor for antimycobacterium drugs control [ 6 ]. Notwithstanding the existence of several analytical methods for the detection of anti-TB drugs, such as high performance liquid chromatography (HPLC) [ 7 ], liquid chromatography/tandem mass spectrometry (LC/MS) [ 8 , 9 , 10 ], micellar electrokinetic capillary chromatography (MEKC) [ 11 ], chemiluminescence [ 12 , 13 , 14 ], fluorimetry [ 15 , 16 ], colorimetry [ 17 ], titrimetry [ 18 ] and voltammetry [ 19 , 20 ], there is still a strong need for the development of portable devices for effective and rapid analysis of these compounds. Among the reported methods, electrochemical detection is recognized as one of the most promising analytical techniques due to its simplicity, cost-effectiveness and potential for in-situ drug monitoring [ 6 , 21 ].…”