Potato- An Important Source of Nutritional Kynurenic Acid

Turski, Michał P.; Kamiński, Piotr; Zgrajka, Wojciech; Turska, Monika; Turski, Waldemar A.

doi:10.1007/s11130-012-0283-3

Cited by 42 publications

(34 citation statements)

References 34 publications

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“…This metabolite is produced from the oxidative conversion of tryptophan to the intermediate kynurenine, which is further transformed to kynurenate. Kynurenate is a potent antioxidant (Lugo‐Huitrón et al, ) and has been detected in a diverse range of plants including medicinal herbs, broccoli, and potato (Turski et al, ; Turski, Kamiński, Zgrajka, Turska, & Turski, ). The activation of the tryptophan/kynurenate pathway is supported by covariation with xanthurenic acid (Figure a), which is also derived from the kynurenine intermediate, and oxo‐glutarate (Figure c), which is a cosubstrate in the kynurenate pathway.…”

Section: Resultsmentioning

confidence: 99%

Common bean varieties demonstrate differential physiological and metabolic responses to the pathogenic fungusSclerotinia sclerotiorum

et al. 2018

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Plant physiology and metabolism are important components of a plant response to microbial pathogens. Physiological resistance of common bean (Phaseolus vulgaris L.) to the fungal pathogen Sclerotinia sclerotiorum has been established, but the mechanisms of resistance are largely unknown. Here, the physiological and metabolic responses of bean varieties that differ in physiological resistance to S. sclerotiorum are investigated. Upon infection, the resistant bean variety A195 had a unique physiological response that included reduced photosynthesis and maintaining a higher leaf surface pH during infection. Leaf metabolomics was performed on healthy tissue adjacent to the necrotic lesion at 16, 24, and 48 hr post inoculation, and 144 metabolites were detected that varied between A195 and Sacramento following infection. The metabolites that varied in leaves included amines/amino acids, organic acids, phytoalexins, and ureides. The metabolic pathways associated with resistance included amine metabolism, uriede-based nitrogen remobilization, antioxidant production, and bean-specific phytoalexin production. A second experiment was conducted in stems of 13 bean genotypes with varying resistance. Stem resistance was associated with phytoalexin production, but unlike leaf metabolism, lipid changes were associated with susceptibility. Taken together, the data supports a multifaceted, physiometabolic response of common bean to S. sclerotiorum that mediates resistance.

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Section: Resultsmentioning

confidence: 99%

Common bean varieties demonstrate differential physiological and metabolic responses to the pathogenic fungusSclerotinia sclerotiorum

et al. 2018

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“…The lowest concentration of KYNA, on the other hand, was found in various kinds of meat, including pork, beef and fish. The content of KYNA in vegetables with the highest content of KYNA was 100× higher in comparison to the content of KYNA in studied meat (Turski et al., , ).…”

Section: Discussionmentioning

confidence: 87%

“…KYNA was isolated and determined according to the methods described previously (Shibata, ; Turski et al., ). Samples were applied to the columns containing cation exchange resin Dowex 50 and the fraction containing KYNA was eluted.…”

Section: Methodsmentioning

confidence: 99%

Presence and content of kynurenic acid in animal feed

Turski

Zgrajka

Siwicki

et al. 2014

Animal Physiology Nutrition

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Kynurenic acid (KYNA) was found to be an antagonist of iontropic glutamate receptors and alpha7 nicotinic acetylcholine receptors. Furthermore, it was documented that KYNA is an agonist of G-protein coupled GPR35 receptors which are mainly present in the gastrointestinal tract. It was also found that KYNA is present in the gastrointestinal tract and that its concentration gradually increases along it. The origin of KYNA in the gastrointestinal tract is not known. Both might be synthesized from tryptophan in it or absorbed from food and other dietary products. Therefore, the aim of the study was to investigate the concentration of KYNA in animal feed. The results indicate that the highest concentration of KYNA was found in animal feeds intended for livestock. The lower amount of KYNA was detected in animal feeds for fish. Interestingly, the lowest amount of KYNA was found in dog and cat feeds. Furthermore, an analysis of KYNA content in animal food ingredients was conducted. The concentration of KYNA found in one of the ingredients – rapeseed meal – was several times higher in comparison to animal feeds studied. The content of KYNA in the remaining feed ingredients tested was significantly lower. This is the first report on the concentration of KYNA in animal feeds. There is a need for further detailed analysis leading to establishing a set of guidelines for animal feeding.

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“…The most recent studies by our group have revealed the antiproliferative activity of kynurenic acid, another endogenous tryptophan metabolite, towards cancer cells, including colon cancer cells (Walczak et al, 2011(Walczak et al, , 2012a. Kynurenic acid was found in human body fluids (Kuc et al, 2006(Kuc et al, , 2008Paluszkiewicz et al, 2009;Walczak et al, 2011) as well as in variety of plant and honeybee derived foodstuffs (Turski et al, , 2012Zgrajka et al, 2013). When administered intragastrically, it was absorbed and transported into the peripheral organs, where it was found in concentrations exerting antiproliferative activities in vitro Walczak et al, 2011).…”

Section: Discussionmentioning

confidence: 99%