Potencial antiinflamatório de Annona glabra, Annonaceae

Siebra, Christian A.; Nardin, Jeanine Marie; Florão, Angela; Rocha, Fabiana H.; Bastos, Denise Zelak; Oliveira, Brás Heleno de; Weffort-Santos, Almeriane Maria

doi:10.1590/s0102-695x2009000100017

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…Several Annona species were found to exhibit anti-parasitic [11], anti-inflammatory [12], and anti-tumor effects. An extract from A. glabra, rich in two diterpenoids displayed a cytotoxic effect on liver cancer cell lines by up-regulating the Bax to Bcl-2 expression ratio [13] and on human leukemia cell lines in vitro [14] .…”

Section: Introductionmentioning

confidence: 99%

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

Ammoury

Younes

Khoury

et al. 2019

BMC Complement Altern Med

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BackgroundThe edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1).MethodsThe anti-proliferative effect of A. cherimola ethanolic leaf extract was evaluated via cell viability assay. Its pro-apoptotic effect was assessed through Cell Death ELISA and dual Annexin V/PI staining. To further investigate the molecular mechanism by which the extract promoted apoptosis and inhibited the proliferation of the AML cells used, apoptotic protein expression was determined through western blots. Extract composition was elucidated by Gas Chromatography-Mass Spectrometry (GC-MS).ResultsOur results showed that the treatment with A. cherimola ethanolic leaf extract exhibited an inhibitory effect on the proliferation of both cancer cell lines used in a dose- and time-dependent manner, with no toxic effects on normal mononuclear cells (MNCs) isolated from human bone marrow. This effect was mediated by DNA fragmentation and apoptosis, as revealed by Cell Death ELISA and dual Annexin V/PI staining. Western blot analysis revealed a Bax/Bcl2 dependent mechanism of apoptosis, as well as PARP cleavage, confirming the apoptotic results observed previously. These effects may be attributed to the presence of terpenes which constitute a large component of the leafy extract, as revealed via GC-MS.ConclusionAll the data presented in our study show that the terpene-rich A. cherimola ethanolic leaf extract exhibits an anti-proliferative and pro-apoptotic effect on the AML cell lines used.

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Section: Introductionmentioning

confidence: 99%

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

Ammoury

Younes

Khoury

et al. 2019

BMC Complement Altern Med

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“…A. purpurea and A. reticulata have been used to treat fever, while anticancer effects have been reported for A. senegalensis and A. muricata [ 105 , 106 ]. Furthermore, A. foetida , A. muricata and A. glabra have been traditionally used to treat rheumatism [ 107 ], while A. reticulata , A. salzmannii , A. foetida and A. squamosa have been described for treating ulcers [ 4 ]. In Indonesia, the fruit juice of A. muricata has used as a diuretic and to treat liver ailments and leprosy [ 108 ], whereas leaves was used to treat spasms, boils and as an aphrodisiac [ 36 ].…”

Section: Annona Generamentioning

confidence: 99%

Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae

2022

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In 1789, the Annonaceae family was catalogued by de Jussieu. It encompasses tropical and subtropical plants which are widespread in distribution across various continents such as Asia, South and Central America, Australia and Africa. The genus of Annona is one of 120 genera of the Annonaceae family and contains more than 119 species of trees and shrubs. Most species are found in tropical America, where over 105 species have been identified. Due to its edible fruits and medicinal properties, Annona is the most studied genus of Annonaceae family. To date, only a limited number of these species have economic value, including A. squamosa L. (sugar apple), A. cherimola Mill. (Cherimoya), A. muricata L. (guanabana or soursop), A. atemoya Mabb. (atemoya), a hybrid between A. cherimola and A. squamosa, A. reticulata L. (custard apple), A. glabra L. (pond-apple) and A. macroprophyllata Donn. Sm. (ilama). Phytochemically, several classes of secondary metabolites, including acetogenins, essential oils, alkaloids, terpenoids and flavonoids. The pharmacological activities of Annona species leaves and seeds include antibacterial, anticancer, antidiabetic and anti-inflammatory properties.

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“…3 Como exemplo, os frutos de Annona spinescens são utilizados no tratamento de úlcera, a infusão de frutos e sementes de Annona crassiflora são utilizados como antidiarreico, as folhas de Annona squamosa são utilizadas no tratamento de furúnculos e úlcera, as folhas de Duguetia lanceolata possuem ação antiinflamatória e as folhas de Annona glabra apresentam ação anti-reumática. [4][5][6][7] Cardiopetalum calophyllum (Figura 1) é uma planta típica do Cerrado, conhecida popularmente como imbirinha, sendo encontrada no Brasil central, Triângulo Mineiro, Goiás e Mato Grosso. 8 Estudos fitoquímicos de cascas do caule de C. calophyllum revelaram a presença de alcaloides isoquinolínicos, destacando-se como constituinte majoritário o alcaloide liriodenina.…”

Section: Composição Química Do óLeo Essencial Deunclassified

Chemical Composition from Essential oil of Cardiopetalum calophyllum Schltdl. (Annonacea

et al. 2016

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Abstract:The Annonaceae family consists of ~135 genera with diverse species and a large number of chemical compounds arising from the secondary metabolism. However, the chemical composition of the essential oil of several species of the family such as Cardiopetalum calophyllum has not been completely determined. The leaves of Cardiopetalum calophyllum (Annonaceae) were collected during different months of the year, between 5:00 and 8:00 h in the morning, to determine the chemical composition of essential oils. In this study, the essential oils extracted from the leaves of C. calophyllum, collected in typical areas of the Cerrado of Goiás, were characterized. The essential oil was extracted by hydrodistillation for 4 h using a Clevenger apparatus. The chemical analysis was carried out by gas chromatography-mass spectrometry (GC-MS), and the constituents were identified by comparing the spectra and retention index obtained with those available in the literature. The chemical analyses showed high concentrations of sesquiterpene hydrocarbons. The antioxidant, antibacterial and antifungal activities of the essential oil of C. calophyllum are described for the first time in this work.Keywords: Cardiopetalum calophyllum; essential oil; sesquiterpenes. ResumoA família Annonaceae é constituída por cerca de 135 gêneros, com uma diversidade extensa de espécies com grande quantidade de compostos químicos diversificados, advindos do metabolismo secundário. Entretanto, as informações sobre a composição química de óleo essencial de várias espécies da família ainda são incipientes, como é o caso da Cardiopetalum calophyllum. As folhas de Cardiopetalum calophyllum (Annonaceae) foram coletadas durante diferentes meses do ano, entre as 05:00 e 08:00 h da manhã, para determinação da composição química dos óleos essenciais. O trabalho teve como objetivo caracterizar quimicamente o óleo essencial extraído de folhas da C. calophyllum, coletadas em áreas típicas do Cerrado goiano. A extração do óleo essencial se deu pelo método de hidrodestilação em aparelho de Clevenger por um período de 4 horas. A análise química do óleo essencial foi realizada por cromatografia em fase gasosa acoplada à espectrometria de massas (CG-EM) e a identificação dos constituintes pela comparação dos espectros obtidos com os espectros disponíveis na literatura e pelo cálculo do índice de retenção. As atividades antioxidante, antibacteriana e antifúngica do óleo essencial de folhas de C. Calophyllum estão sendo descritas pela primeira vez neste trabalho.Palavras-chave: Cardiopetalum calophyllum; óleo essencial; sesquiterpenos.

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Potencial antiinflamatório de Annona glabra, Annonaceae

Cited by 15 publications

References 36 publications

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae

Chemical Composition from Essential oil of Cardiopetalum calophyllum Schltdl. (Annonacea

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