Potenciales evocados cognitivos en pacientes con esclerosis múltiple remitente-recurrente y benigna

Vázquez‐Marrufo, Manuel; González‐Rosa, Juan Manuel; Vaquero-Casares, E; Duque, Paula Andrea; Borges, Marco Antônio Viana; Izquierdo, Guillermo

doi:10.33588/rn.4809.2008295

Cited by 5 publications

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“…This would result in a relatively small RT difference between responses for validly and invalidly cued target locations. Furthermore, this pattern of results should be especially likely to occur when target detection or discrimination does not require highly focused attention, as was the case in previous studies (Gonzalez-Rosa, et al, 2006; Vazquez-Marrufo, et al, 2008; Vázquez-Marrufo, et al, 2009). By contrast, the current study presented a salient peripheral cue, and target stimuli that were difficult to discriminate without focused attention.…”

Section: Discussionsupporting

confidence: 56%

“…To our knowledge, only a few published studies (Gonzalez-Rosa et al, 2006; Paul, Beatty, Schneider, Blanco, & Hames, 1998; Vazquez-Marrufo et al, 2008; Vazquez-Marrufo, et al, 2009) have compared results from MS and control participants using an adaptation of Posner's attention-cueing paradigm. It is interesting that in the subset of those studies that reported reliable group differences in cueing effect magnitudes (Gonzalez-Rosa et al, 2006; Vazquez-Marrufo et al, 2008), smaller cueing effects were found for MS than for control participants.…”

Section: Methodsmentioning

confidence: 99%

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Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Gmeindl¹,

Courtney²

2012

Neuropsychology

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Objective To investigate whether spatial working memory (WM) is impaired in multiple sclerosis (MS), and, if it is, to localize impairment to specific cognitive subprocess(es). Method In Experiment 1, MS and control participants performed computerized memory-span and visuomotor tasks. WM subprocesses were taxed by manipulating (1) the requirement to remember serial order, (2) delay duration, and (3) the presence of irrelevant stimuli during target presentation. In Experiment 2, recall and recognition tests varied the difficulty of WM retrieval. In Experiment 3, an attention-cueing task tested the ability to voluntarily and rapidly reorient attention. Results Performance was worse for MS than for control participants in both spatial recall (Exp. 1 span: 95% CIMS = [5.11, 5.57], 95% CIControls = [5.58, 6.03], p = 0.003, 1-tailed; Exp. 2 span: 95% CIMS = [4.44, 5.54], 95% CIControls = [5.47, 6.57], p = 0.006, 1-tailed) and recognition (accuracy: 95% CIMS = [0.71, 0.81], 95% CIControls = [0.79, 0.88], p = 0.01, 1-tailed) tests. However, there was no evidence for deficits in spatiotemporal binding, maintenance, retrieval, distractor suppression, or visuomotor processing. In contrast, MS participants were abnormally slow to reorient attention (cueing effect (ms): 95% CIMS: [90, 169], 95% CIControls: [29, 107], p = 0.015, 1-tailed). Conclusions Results suggest that, whereas spatial WM is impaired in MS, once spatial information has been adequately encoded into WM, individuals with MS are, on average, able to maintain and retrieve this information. Impoverished encoding of spatial information, however, may be due to inefficient voluntary orienting of attention.

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Section: Discussionsupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Gmeindl¹,

Courtney²

2012

Neuropsychology

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Timing in Auditory Processing in Children with ADHD with Sleep Disorder

Tristão

Filho

Pratesi

et al. 2014

Procedia - Social and Behavioral Sciences

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Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients

et al. 2019

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Functional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing the patient’s quality of life. A primary objective in the cognitive assessment of multiple sclerosis (MS) patients is to find reliable measures utilizing diverse neuroimaging techniques. Moreover, especially relevant in the clinical environment is finding technical approaches that could be applied to individual participants and not only for group analysis. A 64-channel electroencephalographic recording (EEG) was made with thirty participants divided into three groups of equivalent size (N = 10) (healthy control, low-EDSS (1–2.5) and moderate-EDSS (4–6)). Correlation analysis was applied to multiple measures: behavior, neuropsychological tests (Paced Auditory Serial Addition Test, 3 seconds (PASAT-3s) and the Symbol Digit Modality Test (SDMT)), Expanded Disability Status Scale (EDSS), even-related potential (P3) and event-related desynchronization (ERD) parameters and the correlation scores between individual participant’s P3/ERD maps and the healthy grand average P3/ERDmaps. Statistical analysis showed that diverse parameters exhibited significant correlations. A remarkable correlation was the moderate score found between SDMT and EDSS (r = −0.679, p = 0.0009). However, the strongest correlation was between the value of integrated measures (reaction time, P3 and ERD latency) and EDSS (r = 0.699, p = 0.0006). In regard to correlations for grand average maps between groups, the P3 component exhibited a lower score according to a more deteriorated condition (higher EDSS). In contrast, ERD maps remained stable with an increase of EDSS. Lastly, a Z-transformation of individual values of all variables included in the study exhibited heterogeneity in cognitive alterations in the multiple sclerosis participants.

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Potenciales evocados cognitivos en pacientes con esclerosis múltiple remitente-recurrente y benigna

Cited by 5 publications

References 0 publications

Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Deconstructing spatial working memory and attention deficits in multiple sclerosis.

Timing in Auditory Processing in Children with ADHD with Sleep Disorder

Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients

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