Potency of tumeric (Curcuma longa L.) extract and curcumin as anti-obesity by inhibiting the cholesterol and triglycerides synthesis in HepG2 cells

Budiman, Iwan; Tjokropranoto, Rita; Widowati, Wahyu; Fauziah, Nurul; Erawijantari, Pande Putu

doi:10.5455/2320-6012.ijrms20150525

Cited by 16 publications

(8 citation statements)

References 31 publications

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“…Its inhibitory action varies according to its concentration; doses of >0.05 g/100 g have already been shown to result in the reduction of liposynthesis. The expression of genes involved in energy metabolism is affected by turmeric, with a reduction in the accumulation of fat in blood and tissues and a decrease in intracellular levels of lipids (Alappat and Awad 2010;Budiman et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Turmeric and sorghum for egg-laying quails

Silva

Gouveia

Sousa³

et al. 2017

Italian Journal of Animal Science

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The aim of the present study was to assess the effect of adding different turmeric amounts to sorghum-based diets for Japanese quails on animal performance, animal metabolism, yolk colour, egg quality, blood and liver biochemical parameters and sensory attributes of the eggs. The study included 210 egg-laying quails aged 50 days and lasted for 90 days. The study had a completely randomised design with six treatments and five replicates with seven birds per replicate. A control corn-based feed and sorghum-based feeds to which different turmeric levels were added (0%, 0.5%, 1.0%, 1.5% and 2%) were tested. The results showed that the sorghum-based feeds with added turmeric levels did not affect animal performance, metabolisation of protein and ether extract, internal and external quality of eggs, serum biochemical profile, including calcium, phosphorous, protein and liver transaminase enzymes. Blood cholesterol and triglyceride levels decreased when !0.5% percentages of turmeric were added to the feed. Yolk colour of the treatments differed significantly from that of the control, but the yolks were considered well suited for consumption. Turmeric reduced the cholesterol and triglyceride levels in egg-laying quails.

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Section: Discussionmentioning

confidence: 99%

Turmeric and sorghum for egg-laying quails

Silva

Gouveia

Sousa³

et al. 2017

Italian Journal of Animal Science

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“…14 Turmeric has antiadipogenesis potential by inhibiting the synthesis of triglycerides and cholesterol and inhibiting fat droplet formation in HepG2 cells. 15 Another study with human research subjects, acute coronary syndrome patients, were administrating by low doses of curcumin showed a trend of decreasing total cholesterol and LDL cholesterol levels. 16 Turmeric is a yellow spice with curcumin as its active ingredient.…”

Section: Discussionmentioning

confidence: 99%

Activity of Javanese Ginger, Turmeric, Garlic, and Pomegranate Flower on LDL-C and Total-C on Dyslipidemia Model Rats

Larissa

Martioso

Jasaputra

2021

Glob Med Health Commun

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High levels of LDL cholesterol are risk factors for coronary heart disease. Different types of medicinal plants have hypolipidemic effects. The study aimed to compare the potential of Javanese ginger ethanol extract, turmeric, garlic, and pomegranate flowers with rosuvastatin on levels of LDL cholesterol (LDL-C) and total cholesterol (total-C) male Wistar rats dyslipidemia models. This experimental laboratory research was conducted in Maranatha Animal Research Laboratory Bandung and was carried out in January–December 2020. The experimental animals were divided into six groups (n=5): the control group, the Javanese ginger group, the turmeric group, the garlic group, the pomegranate flower group, and the comparison control group. The induction given to experimental animals was administering vitamin D3, a high-fat diet, and propylthiouracil for 14 days. The results showed that the administration of 175 mg/kg BW of garlic ethanol extract (−44.85%), pomegranate flowers (−58.74%), and rosuvastatin (−40.00%) reduced LDL-C compared to control (p<0.05). The administration of 175 mg/kg BW of Javanese ginger ethanol extract (−15.16%), turmeric (−14.02%), garlic (−22.80%), pomegranate flower (−65.24%), and rosuvastatin (−18.70%) reduced total-C compared to controls (p<0.05). The conclusion is that garlic and pomegranate flowers lowered LDL-C, while Javanese ginger, turmeric, garlic, and pomegranate flowers reduced total-C. AKTIVITAS TEMULAWAK, KUNYIT, BAWANG PUTIH, DAN BUNGA DELIMA TERHADAP K-LDL DAN K-TOTAL PADA TIKUS MODEL DISLIPIDEMIAKadar kolesterol LDL yang tinggi adalah faktor risiko penyakit jantung koroner. Berbagai jenis tanaman obat memiliki efek hipolipidemik. Penelitian ini bertujuan membandingkan potensi ekstrak etanol temulawak, kunyit, bawang putih, dan bunga delima dengan rosuvastatin pada kadar kolesterol LDL (K-LDL) dan kolesterol total (K-total) tikus Wistar jantan model dislipidemia. Penelitian laboratorium eksperimental ini dilakukan di Laboratorium Penelitian Hewan Maranatha Bandung dan dilakukan pada Januari–Desember 2020. Hewan coba dibagi menjadi enam kelompok (n=5), yaitu kelompok kontrol, kelompok temulawak, kelompok kunyit, kelompok bawang putih, kelompok bunga delima, dan kelompok pembanding. Induksi yang diberikan kepada hewan coba adalah pemberian vitamin D3, pakan lemak tinggi, dan propyltiouracil selama 14 hari. Hasil penelitian menunjukkan bahwa pemberian 175 mg/kgBB ekstrak etanol bawang putih (−44,85%), bunga delima (−58,74%), dan rosuvastatin (−40,00%) mengurangi K-LDL dibanding dengan kontrol (p<0,05). Pemberian 175 mg/kgBB ekstrak etanol temulawak (−15,16%), kunyit (−14,02%), bawang putih (−22,80%), bunga delima (−65,24%), dan rosuvastatin (−18.70%) mengurangi K-total dibanding dengan kontrol (p<0,05). Kesimpulannya, bunga bawang putih dan delima menurunkan K-LDL, sedangkan temulawak, kunyit, bawang putih, dan bunga delima menurunkan K-total.

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“…The anti-adipogenesis potential of turmeric extract may be due to its ability to retard the formation of lipid droplets, triglycerides, and cholesterol in HepG2 cells. The turmeric extract showed better anti-obesity activity in comparison with curcumin [ 165 ]…”

Section: Health Benefit Potentialmentioning

confidence: 99%

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

Mandal

Sarkar

Chakraborty

2022

Appl Biochem Biotechnol

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Medicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spices and herbs (cardamom, black jeera, fennel, poppy, coriander, fenugreek, bay leaves, clove, chili, cassia bark, black pepper, nutmeg, black mustard, turmeric, saffron, star anise, onion, dill, asafoetida, celery, allspice, kokum, greater galangal, and sweet flag) are described in this review. These spices show many pharmacological activities like anti-inflammatory, antimicrobial, anti-diabetic, anti-obesity, cardiovascular, gastrointestinal, central nervous system, and antioxidant activities. Numerous bioactive compounds are present in these selected spices, such as 1,8-cineole, monoterpene hydrocarbons, γ-terpinene, cuminaldehyde, trans-anethole, fenchone, estragole, benzylisoquinoline alkaloids, eugenol, cinnamaldehyde, piperine, linalool, malabaricone C, safrole, myristicin, elemicin, sinigrin, curcumin, bidemethoxycurcumin, dimethoxycurcumin, crocin, picrocrocin, quercetin, quercetin 4’-O-β-glucoside, apiol, carvone, limonene, α-phellandrene, galactomannan, rosmarinic acid, limonene, capsaicinoids, eugenol, garcinol, and α-asarone. Other than that, various spices are used to synthesize different types of metal-based and polymer-based nanoparticles like zinc oxide, gold, silver, selenium, silica, and chitosan nanoparticles which provide beneficial health effects such as antioxidant, anti-carcinogenic, anti-diabetic, enzyme retardation effect, and antimicrobial activity. The nanoparticles can also be used in environmental pollution management like dye decolorization and in chemical industries to enhance the rate of reaction by the use of catalytic activity of the nanoparticles. The nutritional value, phytochemical properties, health advantages, and both traditional and modern applications of these spices, along with their functions in food fortification, have been thoroughly discussed in this review

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Potency of tumeric (Curcuma longa L.) extract and curcumin as anti-obesity by inhibiting the cholesterol and triglycerides synthesis in HepG2 cells

Cited by 16 publications

References 31 publications

Turmeric and sorghum for egg-laying quails

Turmeric and sorghum for egg-laying quails

Activity of Javanese Ginger, Turmeric, Garlic, and Pomegranate Flower on LDL-C and Total-C on Dyslipidemia Model Rats

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

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