Potensi Imunomodulator Herbal Ekstrak Etanol Daun Pepaya Varietas Calina terhadap Struktur Jaringan Limpa Tikus Putih Galur Wistar

Setiawan, Heru; Wulandari, Sri; Fitriyani, Aritasya Nur

doi:10.19087/jveteriner.2021.22.4.531

Cited by 4 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids will stimulate T cells to produce type 1 T cells [29]. T cells derived from ascites secrete VEGF (vascular endothelial growth factor) and express VEGFR-2 upon activation so that vascular endothelial growth factor directly suppresses T-cell activation via VEGFR-2 so that it can induce angiogenesis [9,30].…”

Section: Resultsmentioning

confidence: 99%

Healing of diabetic ulcers using jamaican cherry leaf extract cream (Muntingia calabura l.) based on collagen density in white rats (Rattus norvegicus)

Balqis,

Aisyah,

Sofyan

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

This research aims to determine the potential of jamaican cherry leaf extract cream (JCLEC) to accelerate the healing process of diabetic ulcers in white rat based on collagen density. The research used 4 month old male white rats (Rattus norvegicus) which were divided into K0 (negative control), KP (silver sulfadiazine), K1 (5% JCLEC), K2 (10% JCLEC), and K3 (15% JCLEC). An incision was made on the back of the rat then given JCLEC. Days 3, 7, and 14 after treatment, the wound tissue was collected after the rat were euthanized. Skin tissue was processed and stained with picrosirious red. The rate of wound healing was observed. Collagen density was presented in scoring. Based on the treatment group and observation time, there was a significant difference in collagen density between the treatment groups compared to the control (P<0.05). Based on the treatment group, the scoring of the collagen density was 1.78±0.6 (K0); 2.56±0.88 (KP); 1.78±0.4 (K1); 2.56±0.88 (K2); and 3.1±0.78 (K3). Based on observation time, the average collagen density scoring was 1.8±0.3 (D-3); 2.6±0.4 (D-7); and 2.8±0.6 (D-14). The conclusion is the 15% JCLEC has the potential to accelerate the healing of diabetic ulcers in white rats by stimulate collagen density.

show abstract

Section: Resultsmentioning

confidence: 99%

Healing of diabetic ulcers using jamaican cherry leaf extract cream (Muntingia calabura l.) based on collagen density in white rats (Rattus norvegicus)

Balqis,

Aisyah,

Sofyan

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…Flavonoids can improve the work of the immune system, saponins can stimulate immune cells to increase the formation of antibodies and tannins play a role in immunostimulant function. 26,27…”

Section: Persentase Jumlah Eosinofilmentioning

confidence: 99%

Leukocyte Differentiation Mice (Mus Musculus) Infected with Plasmodium Berghei after Therapy With Sargassum Duplicatum Extract

Ukratalo

Lateke

2023

Nusantara Scientific Medical Research Journal

View full text Add to dashboard Cite

Leukocytes are white blood cells produced by hematopoietic tissue that serves to help the body fight various infectious diseases as part of the immune system. Sargassum duplicatum contains steroid, alkaloid, phenol, flavonoid, saponin, and tannin compounds that can be immunomodulatory. The purpose of this research is to know the effect of methane extract of brown algae Sargassum duplicatum on the differentiation of leukocyte mice (Mus musculus) infected with Plasmodium berghei. Mice weighing 20-30 grams in Plasmodium berghei infection as much as 0.1 ml per head and left to the percentage of parasitemia reaches 1-5%. Then the mice (Mus musculus) were given brown algae methanol extract (Sargassum duplicatum) at doses 10, 100, and 200 mg / g BW for 4 consecutive days. From day 0 to 6 also made a blood smear to calculate the number of leukocytes. Data analysis will be done using ANOVA. The results showed that the administration of brown algae extracts of Sargassum duplicatum influenced in increasing the number of neutrophils, monocytes, and basophils and decreased the number of eosinophils and lymphocytes of mice infected with Plasmodium berghei to near normal range. Dose 200 mg/kg BB methanol extract of brown alga Sargassum duplicatum is a dose that can affect the number of neutrophils, eosinophils, lymphocytes, and monocytes of mice infected with Plasmodium berghei most closely to normal range.

show abstract

“…Some of the main compounds used in commercially patented immunomodulators can also be found in herbal plants. Indonesia is a country with high biodiversity, and many herbal plants have potential as immunomodulators (Setiawan et al, 2021). One of the herbal plants that have potential as herbal immunomodulators is arabica green coffee beans.…”

Section: Immunomodulatorsmentioning

confidence: 99%

Activity of arabica green coffee bean (Coffea arabica) extract as an immunomodulator in mice (Mus musculus) infected with Staphylococcus aureus

Aurellia,

Subangkit,

Andriyanto

2023

curr biomed

View full text Add to dashboard Cite

Arabica green coffee bean is the most widely produced coffee bean in Indonesia. Studies have shown that arabica green coffee beans are rich in polyphenols and antioxidants, stimulating immune cell proliferation. This study investigated the immunomodulatory activity of arabica green coffee beans (Coffea arabica). Thirty mice (Mus musculus) with an average body weight of 30 g were divided into five groups: negative control, positive control, and groups administered arabica green coffee bean powder extract at doses of 0.03, 0.06, and 0.18 mg/30 g BW. It was orally administered once daily for 14 days. On the 15th day, the mice were intraperitoneally injected with non-pathogenic Staphylococcus aureus. After an hour, mice were necropsied for peritoneal fluid collection. Peritoneal fluid was stained with a peripheral blood smear, and the number of macrophages and lymphocytes was observed under a microscope. Data were analyzed using one-way analysis of variance (ANOVA), followed by Tukey’s test. The group administered with 0.18 mg/30 g body weight (BW) dose showed the highest average of macrophage and lymphocytes compared to the negative control group and any other groups. Arabica green coffee bean powder extract was shown to have immunomodulatory activity, with the highest activity observed at a dosage of 0.18 mg/30 g BW.

show abstract

Potensi Imunomodulator Herbal Ekstrak Etanol Daun Pepaya Varietas Calina terhadap Struktur Jaringan Limpa Tikus Putih Galur Wistar

Cited by 4 publications

References 12 publications

Healing of diabetic ulcers using jamaican cherry leaf extract cream (Muntingia calabura l.) based on collagen density in white rats (Rattus norvegicus)

Healing of diabetic ulcers using jamaican cherry leaf extract cream (Muntingia calabura l.) based on collagen density in white rats (Rattus norvegicus)

Leukocyte Differentiation Mice (Mus Musculus) Infected with Plasmodium Berghei after Therapy With Sargassum Duplicatum Extract

Activity of arabica green coffee bean (Coffea arabica) extract as an immunomodulator in mice (Mus musculus) infected with Staphylococcus aureus

Contact Info

Product

Resources

About