POTENSI SENYAWA BIOAKTIF TANAMAN GENUS &lt;i&gt;Phyllanthus&lt;/i&gt; SEBAGAI INHIBITOR REPLIKASI VIRUS HEPATITIS B

Firdayani,; Kusumaningrum, Susi; Miranti, Yosephine Ria

doi:10.29122/jbbi.v4i2.2589

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…The RMSD value is a benchmark for the docking algorithm to predict the protein-ligand conformation. The RMSD value is good if it is worth <2.0 (Firdayani et al, 2017). According to Pratama (2016), molecular tethering gives results close to experimental experiments if it has an RMSD value of <2.0.…”

Section: Resultsmentioning

confidence: 86%

In Silico, to Determine the Active Compounds of Black Tea and Turmeric in Increasing the Activity of the Enzyme Sod

Hasan

Safithri

Huda

et al. 2022

IJAR

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Damage to cells caused by stress can be reduced by the presence of antioxidants, one of which is Superoxide dismutase (SOD). The role of the active ingredients of black tea and turmeric will be studied using the in-silico method to identify the active compounds as components in SOD activation. The bioavailability and toxicity of the active compounds of black tea and turmeric were studied and followed by molecular docking and virtual games. The parameters studied are Gibbs's free energy (∆G) and binding site similarity (BSS). The results were analyzed using Gibbs's free energy (∆G) and binding site similarity (BSS) parameters. It was found that those that could increase the activity of Cu/Zn SOD enzymes were Epicatechin gallate (black tea) and curcumin (turmeric), with values of -9.5 and -7.4 Kcal/mol and the same BSS value of 81.8%. The control ligand used was beta amyrin. According to Lipinski's rules, Epicatechin gallate and curcumin compounds can be absorbed well and are safe for consumption. This study concludes that Epicatechin gallate, an active compound of black tea, and curcumin, an active compound of turmeric rhizome, have the best potential to increase the activity of Cu/Zn SOD enzymes based on the results of virtual screening and molecular docking. Epicatechin gallate and curcumin are predicted to be well absorbed by the body because they qualify Lipinski's rules and are not toxic and safe for consumption.

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Section: Resultsmentioning

confidence: 86%

In Silico, to Determine the Active Compounds of Black Tea and Turmeric in Increasing the Activity of the Enzyme Sod

Hasan

Safithri

Huda

et al. 2022

IJAR

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“…The prevailing public conviction regarding the potency of the components present in medicinal plants and their associated properties has prompted a significant number of investigations to explore the advantages and viability of plant compounds as commercially viable pharmaceutical agents [5,60]. Recent studies have shown that Phyllantus niruri L. and Phyllantus urinaria L. can be used as HBV inhibitory agents [31,52]. Furthermore, the secondary metabolites in both Meniran species have active and significant antiviral and hepatoprotective benefits in their anti-inflammatory, antioxidant, and anticancer properties [29,48].…”

Section: Discussionmentioning

confidence: 99%

“…Firdayani et al [31] explained that the repanducinat acid contained in Meniran could inhibit viral replication during the formation of the protein shell. Furthermore, Jung et al [52] stated that pure corylaginous compounds significantly inhibit HBV DNA synthesis with HBsAg and HBcAg secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, pure compounds from the Meniran plant were reported to inhibit the replication and expression of HBV in cells used as test models [4,[22][23][24][25][26] and were hepatoprotective [27][28][29][30]. The inhibition process has been shown to occur in viral replication, mutation, and capsid formation [17,31]. This study aimed to review information about the differences between Phyllantus niruri L. and Phyllantus urinaria L., identify bioactive compounds reported as HBV inhibitory agents, and elucidate the mechanisms underlying the occurrence of anti-HBV effects.…”

Section: Introductionmentioning

confidence: 99%

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Activity and potential of Phyllantus niruri L. and Phyllantus urinaria L. as Hepatitis B virus inhibitors: A narrative review of the SANRA protocol

Made Dwi Mertha ADNYANA,

UTOMO,

FAUZIYAH

et al. 2024

jrp

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Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, including Phyllantus niruri L. and Phyllantus urinaria L. Therefore, this study aimed to explore, analyze and compile the activities and potential of Phyllantus niruri L. and Phyllantus urinaria L. as agents of hepatitis B virus (HBV) inhibitors using a narrative review approach. It was conducted based on the Scale for the Assessment of Narrative Review Articles (SANRA) by establishing inclusion and exclusion criteria. The study selected and reviewed 15 out of 38 articles. The Phyllantus genus is a group of seasonal herbs containing bioactive compounds and activity as HBV Inhibitors. In this study, 23 compounds were identified in the two species, including Nirtetralin,

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“…The Food and Drug Administration (FDA) has approved two types of HBV drugs, namely immunomodulators/interferons (IFN-α-2b and peg-IFN-α-2a) and nucleoside analogues (Hu et al, 2019;Tseng et al, 2014), but long-term use of this drug can cause resistance and specific mutations in HBV so that the drug's efficacy decreases (Firdayani et al, 2017;. One of the efforts made is to use the capsid protein of HBV as a drug target because it has an important role in the HBV replication cycle (Chen et al, 2021;Liu, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Naringin's Potential as a Hepatitis B Virus Replication Inhibitor: An in-Silico Study of Secondary Metabolite Compound

Khalil

Akbar

Saputra

et al. 2023

JFSP

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Naringin is a secondary metabolite compound of the flavonoid group which is generally found in plants that are consumed and traditionally used as medicine. The aim of this study was to examine the potential of naringin as a candidate for hepatitis B virus replication inhibitor using an in-silico approach. This research uses exploratory descriptive method with molecular docking analysis was carried out using the blind docking technique. The 3D structures of naringin and reference ligands were collected from the PubChem database, and the 3D structures of target proteins were collected from the PDB database. The target protein used is the hepatitis B virus capsid protein with PDB ID: 5GMZ. Docking analysis was performed using AutoDock Vina which is integrated into PyRx. Docking results were visualized using the PyMol software and Biovia Discovery Studio 2019. The results of the analysis showed that the binding affinity of all simulation models between naringin and the HBV capsid protein ranged from -7.1 to -7.9 kcal/mol. The binding site formed between naringin and the receptor corresponds to the reference ligand, involving the same 12 amino acid residues, namely PHE 23, PRO 25, LEU 30, THR 33, TRP 102, ILE 105, SER 106, PHE 110, TYR 118, ILE 139, LEU 140, and SER 141. Based on these results, it can be concluded that the naringin compound has the same bioactivity as the reference ligand in inhibiting viral replication, so that naringin has the potential as a candidate for hepatitis B virus replication inhibitor

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POTENSI SENYAWA BIOAKTIF TANAMAN GENUS <i>Phyllanthus</i> SEBAGAI INHIBITOR REPLIKASI VIRUS HEPATITIS B

Abstract: In this research, simulations of molecular docking of

Cited by 4 publications

References 11 publications

In Silico, to Determine the Active Compounds of Black Tea and Turmeric in Increasing the Activity of the Enzyme Sod

In Silico, to Determine the Active Compounds of Black Tea and Turmeric in Increasing the Activity of the Enzyme Sod

Activity and potential of Phyllantus niruri L. and Phyllantus urinaria L. as Hepatitis B virus inhibitors: A narrative review of the SANRA protocol

Naringin's Potential as a Hepatitis B Virus Replication Inhibitor: An in-Silico Study of Secondary Metabolite Compound

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