Potensi Toksisitas Andrografolid dari Sambiloto (Andrographis paniculata (Burm.f.) Nees)  pada kulit dan mata secara In Silico

Susanti, Ni Made Pitri; Warditiani, Ni Kadek; Juwianti, Chenme; Wisesa, I Nyoman Triadhi

doi:10.24843/jfu.2017.v06.i01.p09

Cited by 2 publications

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“…= No secondary metabolite compounds were detected Meanwhile, in reflux, adding heat helps break down plant cell walls and increases the solubility of the active compounds in the material, thereby improving the extraction process. In addition, during reflux, the solvent used for the extraction process remains fresh to avoid solvent saturation, which can increase the ability of the solvent to attract compounds (Susanti et al, 2014).…”

Section: Table II Results Of Standardization Of Oil Palm Leaf Dry Mat...mentioning

confidence: 99%

EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.)

Faramayuda,

Windyaswari,

Karlina

et al. 2024

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Oil palm (Elaeis guineensis Jacq.) is a plant that is native to Africa and South America. This plant can grow well in tropical areas, such as Indonesia. Indonesia is currently one of the largest producers of palm oil worldwide. As the area of palm oil plantations increases, the potential for waste from this plant continues to increase. The potential for palm oil leaf waste production in Indonesia is 658 kg dry matter/hectare/year. Palm oil leaf waste has been widely processed into organic fertilizers and animal feeds. This plant has the potential to be developed into a source of traditional medicinal ingredients. Based on the abundant sources of palm oil leaves and their pharmacological potential, palm oil leaves can be used as a source of raw materials for traditional medicine. This study aimed to compare the antioxidant activities of oil palm leaf extracts obtained by maceration and reflux to determine which extraction method produces the best antioxidant activity. Extraction was carried out using 70% ethanol solvent by maceration and reflux. The results of the phytochemical screening showed that oil palm leaves contain flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpene-sesquiterpenes. Antioxidant activity using a UV-Visible spectrophotometer with DPPH free radicals showed that the extract obtained by maceration and reflux methods had IC50 values of 46.61 ± 1.76 ug/mL and 55.21 ± 2.91 ug/mL respectively. Therefore, extraction by maceration produces a better antioxidant activity. Keywords: Palm leaves; Traditional medicine; Extraction; Active compound stability; Antioxidant

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Section: Table II Results Of Standardization Of Oil Palm Leaf Dry Mat...mentioning

confidence: 99%

EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.)

Faramayuda,

Windyaswari,

Karlina

et al. 2024

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“…Mekanisme yang terjadi adalah proses gametogenesis pada tahap proliferasi mengalami penurunan yang mengakibatkan produksi spermatogonia juga akan menurun. Andrografolid dapat mempengaruhi jumlah produksi sel-sel sperma dalam tubuli seminiferi dan dapat berimbas pada jumlah spermatozoa yang dihasilkan (Adelati, Juniarto & Miranti, 2016;Susanti et al, 2017). Penelitian yang dilakukan di India dengan hewan uji tikus jantan, tumbuhan sambiloto dalam bentuk serbuk daun kering dengan dosis 105 mg/kg berat badan yang diberikan selama 60 hari dapat menghentikan spermatogenesis pada tahap perkembangan dan pematangan sel-sel sperma (Dewi, 2013).…”

Section: Pendahuluanunclassified

Pengaruh Ekstrak Etanol Daun Sambiloto Terhadap Jumlah dan Motilitas Spermatozoa Mencit Jantan

2018

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Tanaman sambiloto (Andrographis paniculata Ness.) merupakan salah satu tanaman obat yang dipercaya dapat mengobati berbagai penyakit seperti influenza, anti kanker, meningkatkan ketahanan tubuh dan anti-fertilitas. Penelitian ini bertujuan untuk mengetahui pengaruh dari daun sambiloto terhadap jumlah dan motilitas spermatozoa mencit (Mus musculus L.) jantan galur DDY (Deutschland, Denken, and Yoken). Sebanyak 24 ekor mencit jantan dengan berat antara 100-125gramdibagi menjadi empat kelompok perlakuan yaitu P0, P1, P2 dan P3 dengan masing-masing dosis 0, 84, 140 dan 196 mg/kg berat badan yang diberikan ekstrak etanol secara oral selama 15 hari. Hasil penelitian menunjukkan bahwa kelompok perlakuan P3 (196 mg/kg berat badan) menunjukkan jumlah spermatozoa terbanyak yaitu 7,33 juta/ml, mengalami penurunan sebesar 78,86% terhadap kontrol. Kandungan senyawa andrografolid dan flavonoid pada ekstrak sambiloto diduga kuat menjadi penyebab penurunan jumlah dan motilitas spermatozoa mencit. Hasil penelitian ini memberikan informasi bahwa pemberian ekstrak etanol daun sambiloto berpengaruh terhadap jumlah dan motilitas spermatozoa mencit jantan.

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Potensi Toksisitas Andrografolid dari Sambiloto (Andrographis paniculata (Burm.f.) Nees) pada kulit dan mata secara In Silico

Cited by 2 publications

References 0 publications

EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.)

EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.)

Pengaruh Ekstrak Etanol Daun Sambiloto Terhadap Jumlah dan Motilitas Spermatozoa Mencit Jantan

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