Potent Antiplatelet, Anti-Inflammatory and Antiallergic Isoflavanquinones from the Roots ofAbrus precatorius

Abstract

Five isoflavanquinones have been isolated from the roots of Abrus precatorius L. (Leguminosae). Three of them are new and designated as abruquinones D, E, and F. The pharmacological activities of the isoflavanquinones have been evaluated. The results indicated that abruquinones A, B, and D exhibited remarkable inhibitory effects on the platelet aggregation. The IC50 of abruquinones A and B for the inhibition of the platelet aggregation induced by arachidonic acid (AA) and collagen were less than 5 micrograms/ml, and of abruquinone D, was less than 10 micrograms/ml for that induced by AA. On the other hand, abruquinones A, B, D, and F showed strong anti-inflammatory and antiallergic effects. The IC50 of abruquinones A, B, D, and F for the inhibition of superoxide formation were less than 0.3 micrograms/ml, for the inhibition of the release of both beta-glucuronidase and lysozyme from rat neutrophils and the release of both beta-glucuronidase and histamine from mast cells were less than 1 microgram/ml.

Antitubercular and Antiplasmodial Constituents ofAbrus precatorius

“…Subsequently, we have investigated the active principles from A. precatorius, from which a known isoflavanquinone, abruquinone B (1), and a new derivative, named abruquinone G (2), were isolated. We now report the isolation, characterization and biological activities of the active ingredients from A. precatorius.Abruquinone B (1) was obtained as a brown liquid; its 1 H-and 13 C-NMR spectral data (CDCl 3 ) agreed with that reported in the literature [2]. Abruquinone G (2) was obtained as white needles.…”

“…Abruquinone B (1) was obtained as a brown liquid; its 1 H-and 13 C-NMR spectral data (CDCl 3 ) agreed with that reported in the literature [2]. Abruquinone G (2) was obtained as white needles.…”

“…Abruquinone G (2) possessed mild antiviral and cytotoxic activities, but was inactive against the malarial parasite ( Table 2). Alessandro and co-workers [3] previously isolated abruquinones A, B and C from A. precatorius, while Kuo and co-workers [2] isolated abruquinones A, B, D, E and F from the same plant, and found that these isoflavanquinones possessed antiplatelet, anti-inflammatory and antiallergic activities; these biologically active quinones were subsequently synthesized [4]. To our knowledge, this is the first report on antitubercular, antiplasmodial and antiviral activities of isoflavanquinones.…”

Ethnomedicinal plants used by traditional healers in Phatthalung Province, Peninsular Thailand

“…Korth.antioxidant and antibacterial activities [87], anti-inflammatory and antinociceptive activities [88] Rhinacanthus nasutus (L.) Kurzantimicrobial activity [89], antiallergic activity [90], antifungal and anti-inflammatory activities [91] Senna alata (L. ) Roxb.antiallergic activity [92], antifungal activity [93] Senna tora (L. ) Roxb.antioxidant and antibacterial activities [94] antibacterial activity Stemona tuberosa Lour.antibacterial activity [95]- burns, skin swellingbland Aloe vera (L.) Burn. f.antioxidant and anti-inflammatory activities [96] wound healing property [97]- stop bleedingnauseating Chromolaena odoratum (L.) R. M. King & H. Roxb.hemostatic and wound healing properties [98]Respiratory system- eliminates sputum, cough,sour Abrus precatorius L.anti-inflammatory and antiallergic activity [99]sore throat Albizia myriophylla Benth.antibacterial activity [100] Phyllanthus emblica L.anti-inflammatory activity [101], anti-Coxsackie Virus B3 [102] Tamarindus indica L.antimicrobial activity [103]bitter Solanum trilobatum L.antimicrobial activity [104], anti-inflammatory and analgesic activities [105]Female problemsfat Sida rhombifolia L.antinociceptive and anti-inflammatory activities [106]Nephrological system- diureticbland Orthosiphon aristatus (Blume) Miq.canti-inflammatory activity [107] Pluchea indica (L. ) Less.anti-inflammatory activity [108], antimicrobial activity [109]…”

Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine

“…The second ranked compounds with the herb do not have reference about immunity. The third ranked herb Abrus precatorius had been defined the relation about Antiprotozoal [52, 53], antimicrobial [54–56], anti-inflammatory [57], apoptosis [58, 59], and immunotoxin [60]. Most of the reported literatures indicate that these compounds can have an effect on immunity; therefore we suggest that the selected compounds can have an influence on MX2.…”