Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons

Jodoj, E.; Chiang, Chen Yu; Aston‐Jones, Gary

doi:10.1016/s0306-4522(97)00372-2

Cited by 273 publications

(194 citation statements)

References 73 publications

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“…Evidence for anatomical and functional connectivity between the LC and mPFC (Jodo et al, 1998;Lestienne et al, 1997;Morrison et al, 1979;Sara and Herve-Minvielle, 1995) supported a rationale for examining LC-mPFC coherence, a measure of the synchronous oscillations between brain regions (Engel et al, 2001;Fries, 2005). Our recordings are, to our knowledge, the first to display the striking coherence between the LC and the mPFC in specific frequency bands in the awake, freely moving animal.…”

Section: Social Stress and Lc Network Activitysupporting

confidence: 53%

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Zitnik

Curtis

Wood

et al. 2015

Neuropsychopharmacol

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Early life stress is associated with the development of psychiatric disorders. Because the locus coeruleus-norepinephrine (LC-NE) system is a major stress-response system that is implicated in psychopathology, developmental differences in the response of this system to stress may contribute to increased vulnerability. Here LC single unit and network activity were compared between adult and adolescent rats during resident-intruder stress. In some rats, LC and medial prefrontal cortex (mPFC) coherence was quantified. The initial stress tonically activated LC neurons and induced theta oscillations, while simultaneously decreasing LC auditory-evoked responses in both age groups. Stress increased LC-mPFC coherence within the theta range. With repeated exposures, adolescent LC neuronal and network activity remained elevated even in the absence of the stressor and were unresponsive to stressor presentation. In contrast, LC neurons of adult rats exposed to repeated social stress were relatively inhibited in the absence of the stressor and mounted robust responses upon stressor presentation. LC sensory-evoked responses were selectively blunted in adolescent rats exposed to repeated social stress. Finally, repeated stress decreased LC-mPFC coherence in the high frequency range (beta and gamma) while maintaining strong coherence in the theta range, selectively in adolescents. Together, these results suggest that adaptive mechanisms that promote stress recovery and maintain basal activity of the brain norepinephrine system in the absence of stress are not fully developed or are vulnerable stress-induced impairments in adolescence. The resulting sustained activation of the LC-NE system after repeated social stress may adversely impact cognition and future social behavior of adolescents.

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Section: Social Stress and Lc Network Activitysupporting

confidence: 53%

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Zitnik

Curtis

Wood

et al. 2015

Neuropsychopharmacol

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“…Norepinephrine in mpFC might activate mesoaccumbens dopamine release through excitatory prefrontal cortical projection to ventral tegmental area dopamine cells (18,19) and/or through corticoaccumbal glutamatergic projections (20). Moreover, a role for pFC projections to the locus coeruleus in exerting an excitatory influence can be envisaged because this nucleus has been shown to activate ventral tegmental area dopamine neurons (21)(22)(23), which could lead to increased dopamine release in NAc.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal/accumbal catecholamine system determines motivational salience attribution to both reward- and aversion-related stimuli

Ventura

Morrone

Puglisi-Allegra

2007

Proc. Natl. Acad. Sci. U.S.A.

170

179

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Recent evidence suggests that rewarding and aversive stimuli affect the same brain areas, including medial prefrontal cortex and nucleus accumbens. Although nucleus accumbens is known to respond to salient stimuli, regardless of their hedonic valence, with selective increased dopamine release, little is known about the role of prefrontal cortex in reward-and aversion-related motivation or about the neurotransmitters involved. Here we find that selective norepinephrine depletion in medial prefrontal cortex of mice abolished the increase in the release of norepinephrine by prefrontal cortex and of dopamine by nucleus accumbens that is induced by food, cocaine, or lithium chloride and impaired the place conditioning induced by both lithium chloride (aversion) and food or cocaine (preference). This is evidence that prefrontal cortical norepinephrine transmission is necessary for motivational salience attribution to both reward-and aversion-related stimuli through modulation of dopamine in nucleus accumbens, a brain area involved in all motivated behaviors. motivation ͉ norepinephrine ͉ prefrontal cortex ͉ dopamine ͉ place conditioning

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“…This "top-down" theory raises the important question of whether the task-related neuronal activity of PFC neurons and the increases in frontal cortical NA release are causally interrelated. In monkeys, pyramidal neurons of the PFC send projections to LC NA neurons (Arnsten and Goldman-Rakic, 1984), and there is evidence in rats for a powerful excitatory input of PFC to LC cells (Jodo and Aston-Jones, 1997;Jodo et al, 1998). PFC neurons fire in response to cues that are being memorized and to stimuli that recall stored information and elicit the behavioral response (Fuster, 1973;Kubota et al, 1974;Niki, 1974).…”

Section: Discussionmentioning

confidence: 99%

Noradrenaline and Dopamine Elevations in the Rat Prefrontal Cortex in Spatial Working Memory

Rossetti¹,

Carboni²

2005

J. Neurosci.

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The role of prefrontal cortical dopamine (DA) in the modulation of working memory functions is well documented, but substantial evidence indicates that the locus ceruleus noradrenergic system also modulates working memory via actions within the prefrontal cortex (PFC). This study shows that PFC noradrenaline (NA) and DA dialysate levels phasically increase when rats perform correctly in a delayed alternation task in a T-maze, a test of spatial working memory. However, NA levels were markedly enhanced in animals trained to alternate compared with rats that acquired the spatial information about the location of food in the maze but were untrained to make a choice to obtain the reward. In contrast, PFC DA elevations occurred independently of whether the animal had acquired the trial-specific information for correct task execution. The contribution of anticipatory responses to catecholamine efflux was also evaluated by exposing rats to an environment signaling the presence of the reward in the successive alternation task. No conditioned NA efflux was observed in either group. In contrast, in both groups, DA efflux increased in the anticipatory phase of the test to the same levels of those reached during the task. These data provide the first direct evidence for a selective activation of PFC NA transmission during a spatial working memory task. We propose that, in the working memory task, DA is primarily associated with reward expectancy, whereas NA is involved in the active maintenance of the information about a goal and the rules to achieve it.

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Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons

Cited by 273 publications

References 73 publications

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Prefrontal/accumbal catecholamine system determines motivational salience attribution to both reward- and aversion-related stimuli

Noradrenaline and Dopamine Elevations in the Rat Prefrontal Cortex in Spatial Working Memory

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