Potential anti-Alzheimer’s disease activities of the roots of Desmodium caudatum

Guo, Jia; Feng, Xiaohe; Zhou, Shuping; Wenxia, Yan; Meng, Dali

doi:10.1016/j.indcrop.2016.06.018

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…Currently, there are only five drugs approved by the US FDA to minimize the progression of symptoms related to AD. These are natural product-based compounds, which include the acetylcholinesterase inhibitors, galantamine, revastigmine, donepezil, and tacrine, and the NMDA receptor antagonist memantine (Guo et al 2016;Huang et al 2019). These drugs only provide symptomatic relief of AD without significant effectiveness in the disease progression and prevention.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells

Tan

2020

3 Biotech

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The purified oxindole alkaloids, isomitraphylline and mitraphylline from Uncaria perrottetii, revealed their ability to break amyloid aggregates in vitro suggesting their therapeutic potentials in Alzheimer's disease (AD). Thioflavin-T assay for assessing amyloid-beta (Aβ) aggregation of these alkaloids exhibited inhibitions at 60.321% ± 2.61 (50 μM) for isomitraphylline and 43.17% ± 3.48 (50 μM) for mitraphylline. Neuroprotective effects were elaborated against Aβ-induced SH-SY5Y cells at 20 μM and 10 μM for isomitraphylline, and 20 μM for mitraphylline. In addition, both alkaloids attenuated and protected the H 2 O 2 -induced SH-SY5Y cell cytotoxicity at 20 μM. The intracellular ROS levels of SH-SY5Y cells from H 2 O 2 -induced oxidative stress were reduced at 20 μM and 10 μM, and the mitochondrial membrane potentials of Aβ-induced SH-SY5Y cells were protected at 20 μM. The overall results suggested the potentials of both alkaloids to target certain pathological biomarkers of AD and could be further investigated as therapeutic or preventive drug leads against AD.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells

Tan

2020

3 Biotech

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“…Its stems and roots have been used medicinally to treat various diseases like fever, dysentery, icterohepatitis, and abscess [15]. In a previous report, the flavonoids in O. caudatum exhibited free radical scavenging abilities and anti-Aβ aggregation effects, which revealed the close associations between O. caudatum and anti-AD biological activities [16]. However, the biological activities of alkaloids, triterpenoids, and other phenolics from this plant have not been studied in depth.…”

Section: Introductionmentioning

confidence: 99%

Systems Pharmacological Approach to Investigate the Mechanism of Ohwia caudata for Application to Alzheimer’s Disease

Sun

Wang

et al. 2019

Molecules

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Ohwia caudata (OC)—a traditional Chinese medicine (TCM)—has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer’s disease (AD) only focused on single targets and its mechanisms, while no report had shown about the synergistic mechanism of the constituents from OC related to their potential treatment on dementia in any database. This study aimed to predict the bioactive targets constituents and find potential compounds from OC with better oral bioavailability and blood–brain barrier permeability against AD, by using a system network level-based in silico approach. The results revealed that two new flavonoids, and another 26 compounds isolated from OC in our lab, were highly connected to AD-related signaling pathways and biological processes, which were confirmed by compound–target network, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, respectively. Predicted by the virtual screening and various network pharmacology methods, we found the multiple mechanisms of OC, which are effective for alleviating AD symptoms through multiple targets in a synergetic way.

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“…Its root or whole plant was used as a traditional Chinese medicine to treat fever, gastroenteritis, dysentery, rheumatic arthritis. Modern pharmacological studies demonstrated that Desmodium caudatum had analgesic, anti-inflammatory ), antioxidant (Li et al 2013, anti-Alzheimer's disease (Guo et al 2016), anti-MRSA (methicillin-resistant Staphylococcus aureus) (Sasaki et al 2012a) and antifungal activities (Sasaki et al 2012b), and inhibitory activity against the filmforming growth of Zygosaccharomyces rouxii F51 (Sasaki et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostical study of Desmodium caudatum

Lin

Tang

et al. 2019

An. Acad. Bras. Ciênc.

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Desmodium caudatum (Thunb.) DC, is an evergreen plant widely used in the central and southern China with great economic value for their medical values on fever, dysentery, gastroenteritis, rectal prolapse, snake bites, mastitis, and boils carbuncle. Despite its extensive uses as a traditional Chinese medicine, no systematic research on the identification of Desmodium caudatum has been reported. In this study, traditional pharmacognostical identification including the botanical origin and morphological characters, medicinal material characters, microscopic characters, physicochemical parameters determination and phytochemical screening, and DNA barcoding analysis were employed to establish an accurate and effective identification system of Desmodium caudatum. In addition, the molecular pharmacognosy study was adopted in order to identify the samples more accurately. The ITS loci of the nuclear genome and psbA-trnH loci of the chloroplast genome were selected and evaluated, which were the most variable loci. The study will be beneficial to the development of the quality standard and the identification of species.

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Potential anti-Alzheimer’s disease activities of the roots of Desmodium caudatum

Cited by 14 publications

References 26 publications

Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells

Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells

Systems Pharmacological Approach to Investigate the Mechanism of Ohwia caudata for Application to Alzheimer’s Disease

Pharmacognostical study of Desmodium caudatum

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