Potential antimicrobial, antidiabetic, catalytic, antioxidant and ROS/RNS inhibitory activities of <i>Silybum marianum</i> mediated biosynthesized copper oxide nanoparticles

Iqbal, Junaid; Andleeb, Anisa; Ashraf, Hajra; Meer, Bisma; Mehmood, Azra; Jan, Hasnain; Zaman, Gouhar; Nadeem, Muhammad; Drouet, Samantha; Fazal, Hina; Giglioli-Guivarc’h, Nathalie; Hano, Christophe; Abbasi, Bilal Haider

doi:10.1039/d2ra01929a

Cited by 30 publications

(11 citation statements)

References 67 publications

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“…The results showed that synthetic CuNPs had a modest level of inhibition for the -amylase enzymes, which is comparable to the sample's percent inhibition. At 1000 µg/ml concentration, CuNPs inhibited the -amylase enzyme by 76.03±1.14 %, which is roughly comparable to the other report of Silybum marianum copper nanoparticles [26]. Our research suggested that the LACuNPs have a significant capacity for enzyme inhibition.…”

Section: Discussionsupporting

confidence: 87%

In vitro Anti-inflammatory, Anti-diabetic and Anticancer Properties of Copper Nanoparticles Synthesized by Medicinal Plant Leucas aspera (Willd)

Bhuvaneswari¹,

Nisha²,

Kalimuthu³

et al. 2023

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Introduction:The present study focuses on the use of Leucas aspera aqueous extract as a reduction agent for the synthesis of copper nanoparticles (CuNPs). The entire plant is employed in conventional medicine and as an insecticide. Scientific research has been done on the plant's potential as an anti-inflammatory, analgesic, and wound-healing agent. Intoxication by cobra venom also makes use of it. This study was intended to explore the in vitro anti-inflammatory, antidiabetic and anticancer activities of copper nanoparticles. Methods: Protein denaturation and membrane stabilization of human red blood cells (HRBC) were used to assess the in vitro anti-inflammatory activity. The antidiabetic activity of the CuNPs was evaluated by inhibiting both amylase and glucosidase in vitro, whereas anticancer activity against vero and MCF-7 cell line. Results: The Leucas aspera copper nanoparticles (LACuNPs) showed a dose dependent -inflammatory activity. The highest inhibition percentage in protein denaturation is 70.30±1.72% and 67.68±1.41% in HRBC membrane stabilization at 1000µg/ml concentration. In vitro antidiabetic activity exhibited 76.03 ± 1.14 of α-amylase and 71.54 ± 1.55 at α-glucosidase inhibition assay. The in vitro anti-cancer study revealed 50% apoptosis (IC 50 ) of LACuNPs treated vero and MCF7 are displayed as 248.84±0.01 µg/ml and 137.39±1.51, respectively. Conclusion: The results clearly demonstrated the application of biosynthesized LACuNPs as potential anti-inflammatory, anti-diabetic, and anticancer agents in addition to their environmental friendliness.

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Section: Discussionsupporting

confidence: 87%

In vitro Anti-inflammatory, Anti-diabetic and Anticancer Properties of Copper Nanoparticles Synthesized by Medicinal Plant Leucas aspera (Willd)

Bhuvaneswari¹,

Nisha²,

Kalimuthu³

et al. 2023

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“…Nanotechnology has been recently exploited as a tool to investigate unilluminated approaches in many ways, such as artificial implants, imaging, targeted drug delivery, sensing and gene-delivery systems [ 1 ]. Generally, nanoparticles [ 2 ] constitute 20–15,000 atoms, their size is smaller than 100 nanometers, and they exist in a realm that bestrides the Newtonian and quantum scales. Nanoparticles can be generated from various materials in numerous shapes, such as wires, spheres, tubes, and rods [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Assisted Synthesis and Characterization of Zinc Oxide Nanoparticles from Lepidium sativum and Their Potent Antioxidant, Antibacterial and Anticancer Activities

et al. 2022

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Nanotechnology is an emerging area of research that deals with the production, manipulation, and application of nanoscale materials. Bio-assisted synthesis is of particular interest nowadays, to overcome the limitations associated with the physical and chemical means. The aim of this study was to synthesize ZnO nanoparticles (NPs) for the first time, utilizing the seed extract of Lepidium sativum. The synthesized NPs were confirmed through various spectroscopy and imagining techniques, such as XRD, FTIR, HPLC, and SEM. The characterized NPs were then examined for various in vitro biological assays. Crystalline, hexagonal-structured NPs with an average particle size of 25.6 nm were obtained. Biosynthesized ZnO NPs exhibited potent antioxidant activities, effective α-amylase inhibition, moderate urease inhibition (56%), high lipase-inhibition (71%) activities, moderate cytotoxic potential, and significant antibacterial activity. Gene expression of caspase in HepG2 cells was enhanced along with elevated production of ROS/RNS, while membrane integrity was disturbed upon the exposure of NPs. Overall results indicated that bio-assisted ZnO NPs exhibit excellent biological potential and could be exploited for future biomedical applications. particularly in antimicrobial and cancer therapeutics. Moreover, this is the first comprehensive study on Lepidium sativum-mediated synthesis of ZnO nanoparticles and evaluation of their biological activities.

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“…A recent investigation reported that silver NPs synthesized from Phagnalon niveum methanol extract demonstrated antidiabetic activity by reducing the blood glucose level and also reduced the body weight of rats in 1 to 21 days [ 178 ]. Spherical shaped-CuO NPs synthesized from Silybum marianum seed extract displayed great enzymatic inhibitory activity against ureases, alpha-amylase, and lipases so it was concluded that they can act as antidiabetic agents [ 179 ]. ZnO NPs and Au NPs which are synthesized using Dicoma anomala and Eclipta alba , respectively, are good alternative sources for antidiabetic medicine [ 98 , 117 ].…”

Section: Application Of Asteraceae -Based Nanopart...mentioning

confidence: 99%

Green Synthesis of Bioinspired Nanoparticles Mediated from Plant Extracts of Asteraceae Family for Potential Biological Applications

et al. 2023

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The Asteraceae family is one of the largest families in the plant kingdom with many of them extensively used for significant traditional and medicinal values. Being a rich source of various phytochemicals, they have found numerous applications in various biological fields and have been extensively used for therapeutic purposes. Owing to its potential phytochemicals present and biological activity, these plants have found their way into pharmaceutical industry as well as in various aspects of nanotechnology such as green synthesis of metal oxide nanoparticles. The nanoparticles developed from the plants of Asteraceae family are highly stable, less expensive, non-toxic, and eco-friendly. Synthesized Asteraceae-mediated nanoparticles have extensive applications in antibacterial, antifungal, antioxidant, anticancer, antidiabetic, and photocatalytic degradation activities. This current review provides an opportunity to understand the recent trend to design and develop strategies for advanced nanoparticles through green synthesis. Here, the review discussed about the plant parts, extraction methods, synthesis, solvents utilized, phytochemicals involved optimization conditions, characterization techniques, and toxicity of nanoparticles using species of Asteraceae and their potential applications for human welfare. Constraints and future prospects for green synthesis of nanoparticles from members of the Asteraceae family are summarized.

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Potential antimicrobial, antidiabetic, catalytic, antioxidant and ROS/RNS inhibitory activities of Silybum marianum mediated biosynthesized copper oxide nanoparticles

Abstract: Use of medicinal plants for the biosynthesis of nanoparticles offers several advantages over other synthesis approaches.

Cited by 30 publications

References 67 publications

In vitro Anti-inflammatory, Anti-diabetic and Anticancer Properties of Copper Nanoparticles Synthesized by Medicinal Plant Leucas aspera (Willd)

In vitro Anti-inflammatory, Anti-diabetic and Anticancer Properties of Copper Nanoparticles Synthesized by Medicinal Plant Leucas aspera (Willd)

Bio-Assisted Synthesis and Characterization of Zinc Oxide Nanoparticles from Lepidium sativum and Their Potent Antioxidant, Antibacterial and Anticancer Activities

Green Synthesis of Bioinspired Nanoparticles Mediated from Plant Extracts of Asteraceae Family for Potential Biological Applications

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