Potential antitumor activity of garlic against colorectal cancer: focus on the molecular mechanisms of action

Oravetz, Kinga; Todea, Adelina-Violeta; Bălăcescu, Ovidiu; Cruceriu, Daniel; Rákosy-Tican, Elena

doi:10.1007/s00394-023-03166-0

Cited by 9 publications

(3 citation statements)

References 79 publications

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“…There are some good reviews about cancer chemo-preventive roles of garlic in wide variety of cancers. Majority of the reviews have analyzed cancer chemo-preventive properties of garlic on the basis of their bioactive molecules and different cancers [30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

Farooqi,

Mobeen,

Attar

et al. 2024

Food Science and Human Wellness

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High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution. Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity. Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic (Allium sativum). Importantly, garlic and its biologically active chemicals targeted oncogenic signaling cascades. In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

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Section: Introductionmentioning

confidence: 99%

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

Farooqi,

Mobeen,

Attar

et al. 2024

Food Science and Human Wellness

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“…13 For example, caspase 9; an initiator of tumor-mediated apoptosis is expressed at low levels in many tumor cell lines. 14 The modulation of anti-apoptotic and pro-apoptotic gene expression contributes to increased proliferation and survival resulting in tumor growth, suggesting potential as druggable treatment targets. 15…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abd El-Lateef,

Bafail,

Alhalees

et al. 2024

RSC Adv.

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“…The cytotoxic action of garlic is attributed mainly to allicin and other thiosulfinates, generated by alliinase upon crushing or other types of damage to garlic [ 57 , 58 ]. However, garlic is also rich in antioxidants, especially phenolic compounds, including flavonoids, among them quercetin derivatives [ 59 , 60 ], which contribute to its pro-health properties [ 2 , 61 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

Furdak,

Pieńkowska,

Kapusta

et al. 2023

Molecules

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Garlic is known to be rich in antioxidants, inhibit the proliferation of various cancer cells, and hamper cancer formation and growth, but various forms of garlic can differ greatly in these respects. This study aimed to compare the antioxidant properties of acetone, ethanol, and aqueous extracts of fresh Polish and Spanish garlic, black and granulated garlic, as well as fresh and dried ramsons. Extracts of black and granulated garlic showed the lowest total antioxidant capacity (TAC). The content of phenolic compounds correlated with TAC measured by ABTS• decolorization and FRAP methods, and with the results of FRAP and DPPH• decolorization assays. Garlic extracts inhibited the proliferation of PEO1 and SKOV3 ovarian cancer cells and, usually to a smaller extent, MRC-5 fibroblasts. PBS extracts of fresh Spanish garlic showed the highest potency for inhibition of proliferation of PEO1 cells (IC50 of 0.71 µg extract dry mass/100 µL medium). No significant correlation was found between the potency for inhibition of proliferation and the content of phenolics or flavonoids, confirming that phenolics are the main determinants of TAC but do not contribute significantly to the antiproliferative effects of garlic.

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Potential antitumor activity of garlic against colorectal cancer: focus on the molecular mechanisms of action

Cited by 9 publications

References 79 publications

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Comparison of Antioxidant and Antiproliferative Effects of Various Forms of Garlic and Ramsons

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