Potential Applications of Nanomaterials to Quench the Cytokine Storm in Coronavirus Disease 19

Pisani, Anissa; Pompa, Pier Paolo; Bardi, Giuseppe

doi:10.3389/fbioe.2020.00906

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Under the severe conditions, Covid-19 patients suffer from major invasion and damage impact on lung and the juxtaposed endothelial tissue by innate immune phagocytes (neutrophils and macrophages) (Pisani et al, 2020). To overcome this critical issue, it is recommended to use anti-IL-6 antibody tocilizumab and Siltuximab in the clinical trials.…”

Section: Immunomodulation Aspect In the Context Of Nanomaterial-basedmentioning

confidence: 99%

“…To overcome this critical issue, it is recommended to use anti-IL-6 antibody tocilizumab and Siltuximab in the clinical trials. Nevertheless, care should be taken for the effective control and suppression of innate immunity associated with cytokine production (Pisani et al, 2020). Nano based systems plausibly counteract these critical issues and might have the potential to improve the specificity and controlled immunosuppressant delivery.…”

Section: Immunomodulation Aspect In the Context Of Nanomaterial-basedmentioning

confidence: 99%

“…In a cytokine storm, the outcomes are the Hyperinflammation and macrophage activation syndrome, uncontrolled production of IL-1β, IL-6, and TNF-α (knows as proinflammatory cytokines). Under severe conditions, Covid-19 patients have the major invade and damage impact on lung and the juxtaposed endothelial tissue by innate immune phagocytes (neutrophils and macrophages) (Pisani et al, 2020). To overcome this critical issue, the recommended antibodies like anti-IL-6 antibody tocilizumab and Siltuximab under the clinical trials.…”

Section: Treatmentmentioning

confidence: 99%

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The Perspective on Bio-Nano Interface Technology for Covid-19

Kamaraj¹

2020

Front. Nanotechnol.

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The field of bio-nano interfaces paves the way for a better understanding, development, and implementation of the advanced biotechnological process. Interfacing biomolecules with the nanomaterials will result in the development of new tools and techniques that, in turn, will enable to explore the fundamental process at the nano level and fabricate cost-effective portable devices. Fascinating biomolecules like DNA, RNA and proteins in the regime of nanoscale are intelligent materials that are capable of storing the information and controlling the basic structure and function of the complex biological systems. Following this concept, the current pandemic situation would be a natural selection process, where the selective pressure is on the ssRNA of Covid-19 to choose the suitable progeny for survival. Consequently, the interaction of human DNA invoking response with Covid-19 happens at the nanoscale and it could be a better candidate to provoke combat against the virus. The extent of this interaction would give us the insights at the nanotechnological level to tackle the prevention, diagnosis and treatment for Covid-19. Herein, the possible features and obstacles in Covid-19 and a probable solution from the advent of nanotechnology are discussed to address the current necessity. Moreover, the perspective sustainable green graph mask that can be prepared using green plant extract/graphene (Bio-Nano composite mask) is suggested for the possible protection of virus-like Covid-19. The composite material will not only effectively trap the virus but also inactivate the virus due to the presence of antiviral compounds in the plant extracts.

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Section: Immunomodulation Aspect In the Context Of Nanomaterial-basedmentioning

confidence: 99%

Section: Immunomodulation Aspect In the Context Of Nanomaterial-basedmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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The Perspective on Bio-Nano Interface Technology for Covid-19

Kamaraj¹

2020

Front. Nanotechnol.

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“…A variety of NMs show amazing drug/gene delivery performances or immunomodulatory properties [7]. Some of them already have a key role in current therapies, especially in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine delivery [8,9], whereas others show potential applications aimed at interfering with abnormal immune reactions like coronavirus disease 2019 (COVID-19)-induced cytokine storm [10].…”

Section: Introductionmentioning

confidence: 99%

Immunology of biodegradable nanoparticles: a brief overview on a wide growing field

Pisani

Bardi

2021

Explor Immunol

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Immunity is continuously evolving by evolutionary mechanisms shaped by pathogenic stimuli of different kinds. Man-made nanomaterials (NMs) have been developed in the last decades and represent a novel challenge for our immune system, especially when applied to medical science. Toxicological studies of such nanoparticles (NPs) revealed that size, shape, and surface chemistry are key parameters to understand their noxious effects on cellular mechanisms. Less is known on the immune reactions to NMs since prolonged exposure data are not so detailed as the results for acute administration. The importance of immunity to biocompatible NPs is underlined by their increasing use as drug or gene delivery carriers in common pharmaceutical preparations and vaccines. In the latter case, the immunomodulatory properties of NMs allow their use also as efficient adjuvants to enhance the innate immune response. In the current manuscript, the authors discuss the main concepts in this fast-growing field by restricting our view to NMs with consolidated application in biomedicine.

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“…Various means have been applied to combat this pandemic, such as novel drugs, new therapeutic approaches for difficult cases, as well as new outlines for clinical management [ 1 , 2 ]. However, among the various modalities that could halt this pandemic, including hypothesized nonconventional approaches using nanomaterials [ 3 ], the achievement of herd immunity is the optimal solution. Herd immunity, also known as community immunity, is reached when a large amount of the population within a community becomes immune to a specific disease (whether naturally or artificially immunized) ending the infectious agent spread [ 4 ].…”

mentioning

confidence: 99%

Nano-Carriers of COVID-19 Vaccines: The Main Pillars of Efficacy

Constantin

Pisani

Bardi

et al. 2021

Nanomedicine (Lond.)

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As the current COVID-19 pandemic illustrates, vaccination is the most powerful method of disease prevention and public confidence in vaccines depends on their safety and efficacy. The information gathered in the current pandemic is growing at an accelerated pace. Both the key vital protein DNA/RNA messengers and the delivery carriers are the elements of a puzzle including their interactions with the immune system to suppress SARS-CoV-2 infection. A new nano-era is beginning in the vaccine development field and an array of side applications for diagnostic and antiviral tools will likely emerge. This review focuses on the evolution of vaccine carriers up to COVID-19-aimed nanoparticles and the immune-related adverse effects imposed by these nanocarriers.

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Potential Applications of Nanomaterials to Quench the Cytokine Storm in Coronavirus Disease 19

Cited by 10 publications

References 41 publications

The Perspective on Bio-Nano Interface Technology for Covid-19

The Perspective on Bio-Nano Interface Technology for Covid-19

Immunology of biodegradable nanoparticles: a brief overview on a wide growing field

Nano-Carriers of COVID-19 Vaccines: The Main Pillars of Efficacy

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