Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia

Bayhan, Gökhan; Koçyiğit, Yüksel; Atamer, Aytaç; Atamer, Yıldız; Akkuş, Zeki

doi:10.1080/09513590500097382

Cited by 91 publications

(81 citation statements)

References 24 publications

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“…Similar results were reported in another study. 37 LDL-C/HDL-C ratio has been found to be considerably higher in women with eclampsia compared to normotensive pregnant women. 35,43 TC/HDL-C has been found to be lower during pregnancy but elevated significantly in both pre-eclampsia and eclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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Section: Discussionmentioning

confidence: 99%

“…Similar observations have been observed in PIH subject in other studies. 24,37 The TC/HDL-C ratio is one of the determinants of the predisposition to the risk of atherosclerosis. A high TC/HDL-C ratio (>4.5 in men, >5 in women) is considered to be a risk factor for atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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show abstract

“…Abnormal lipids, in particular higher triglycerides and increased lipid peroxidation, are possibly involved in the pathogenesis of PE through endothelial dysfunction [24][25][26]. A metaanalysis of 19 case-control and 3 cohort studies showed a rising risk of PE with increasing triglycerides, at the time of PE, preceding PE diagnosis and postpartum [27].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Barrett

Nitert²,

McIntyre³

et al. 2014

J Diabetes Metab 2013

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“…Это свидетельствует о том, что их ор-ганизм подвергается существенному оксидативному стрессу [68]. Уровень пероксидации липидов повы-шен в плаценте женщин с преэклампсией, а также в крови женщин, у плодов которых имелся синдром задержки развития [69,70].…”

Section: роль оксидативного стресса как эпигенетического фактораunclassified

Perinatal programming and cardiomyocyte aging

Ковтун¹,

Цывьян²,

Соловьева³

2017

Ross. vestn. perinatol. pediatr.

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Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia

Abstract: Our findings suggest that high Lp(a), lipid peroxidation, LDL-C and TG, and low HDL-C and Apo A-I levels, are important risk factors for atherosclerosis among preeclamptic women.

Cited by 91 publications

References 24 publications

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Perinatal programming and cardiomyocyte aging

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