Potential avenue of genetic engineered algal derived bioactive compounds: influencing parameters, challenges and future prospects

Kothari, Richa; Singh, Har Mohan; Azam, Rifat; Goria, Kajol; Bharti, Anu; Singh, Anita; Bajar, Somvir; Pathak, Ashish; Pandey, Aditya; Tyagi, V.V.

doi:10.1007/s11101-023-09859-y

Cited by 4 publications

(2 citation statements)

References 165 publications

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“…Marine Synechococcus has many advantages such as easy culture and a high growth rate. Recent studies have shown that Synechococcus contain various active components, such as proteins, pigments, and fatty acids ( Liu et al, 2021 ; Kothari et al, 2023 ). In particular, unsaturated fatty acids have been proven to have antioxidant, anti-inflammatory and anti-AD-related activities.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

Xie,

Chen,

et al. 2023

Front. Pharmacol.

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In recent years, the Alzheimer’s disease (AD) epidemic has become one of the largest global healthcare crises. Besides, the available systemic therapies for AD are still inadequate. Due to the insufficient therapeutic options, new treatment strategies are urgently needed to achieve a satisfactory therapeutic effect. Marine bio-resources have been accepted as one of the most economically viable and sustainable sources with potential applications for drug discovery and development. In this study, a marine cyanobacteria–Synechococcus sp. XM-24 was selected as the object of research, to systematically investigate its therapeutic potential mechanisms for AD. The major active compounds derived from the Synechococcus sp. biomass were identified via pyrolysis-gas chromatography-mass spectrometry (GC-MS), and 22 compounds were identified in this strain. The most abundant chemical compounds was (E)-octadec-11-enoic acid, with the peak area of 30.6%. Follow by tridecanoic acid, 12-methyl- and hexadecanoic acid, with a peak area of 23.26% and 18.23%, respectively. GC-MS analysis also identified indolizine, isoquinoline, 3,4-dihydro- and Phthalazine, 1-methyl-, as well as alkene and alkane from the strain. After the chemical toxicity test, 10 compounds were finally collected to do the further analysis. Then, network pharmacology and molecular docking were adopted to systematically study the potential anti-AD mechanism of these compounds. Based on the analysis, the 10 Synechococcus-derived active compounds could interact with 128 related anti-AD targets. Among them, epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGFA) and mitogen-activated protein kinase 3 (MAPK3) were the major targets. Furthermore, the compounds N-capric acid isopropyl ester, (E)-octadec-11-enoic acid, and 2H-Pyran-2,4(3H)-dione, dihydro-6-methyl- obtained higher degrees in the compounds-intersection targets network analysis, indicating these compounds may play more important role in the process of anti-AD. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that these active compounds exert the anti-AD effects mainly through PI3K-Akt signaling pathway, neuroactive ligand-receptor interaction and ras signaling pathway. Our study identified Synechococcus-derived bioactive compounds have the potential for application to AD by targeting multiple targets and related pathways, which will provide a foundation for future research on applications of marine cyanobacteria in the functional drug industry.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

Xie,

Chen,

et al. 2023

Front. Pharmacol.

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“…Also, the endogenous ABA was reported to increase (10×) in microalga Draparnaldia mutabilis and JA increased (15×) in Draparnaldia salina when grown in osmotic stress (50 and 85 mM NaCl), suggesting that the endogenous ABA and JA play important roles in salt tolerance in microalgae [38]. In seaweeds, CRISPR technology can be used to target and modify genes involved in hormone production or response pathways in seaweed and shed light on the regulatory mechanisms [222].…”

Section: Perspectivesmentioning

confidence: 99%

Phytohormones and Pheromones in the Phycology Literature: Benchmarking of Data-Set and Developing Critical Tools of Biotechnological Implications for Commercial Aquaculture Industry

Rathod,

Bhushan,

Mantri

2023

Phycology

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Plant hormones and pheromones are natural compounds involved in the growth, development, and reproductive processes. There is a plethora of studies on hormones and pheromones in terrestrial plants, but such investigations are few in the phycological literature. There are striking similarities between the chemical diversity, biosynthetic processes, roles, and actions of hormones and pheromones in both higher angiospermic plants and algae. However, there are substantial knowledge gaps in understanding the genes responsible for hormone biosynthesis and regulation in algae. Efforts have focused on identifying the genes and proteins involved in these processes, shedding light on lateral gene transfer and evolutionary outcomes. This comprehensive review contributes to benchmarking data and essential biotechnological tools, particularly for the aquaculture industry where seaweed is economically crucial. Advanced techniques in plant hormones and pheromones can revolutionize commercial aquaculture by using synthetic analogs to enhance growth, yield, and reproductive control, thereby addressing seasonal limitations and enabling sustainable seedling production. To the best of our knowledge, this is the first comprehensive review that focuses on biosynthetic pathways and modes of action (of five plant hormones and five pheromones), roles (of 11 hormones and 29 pheromones), and extraction protocols (of four hormones and six pheromones) reported in the phycological domain.

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Cyanobacterial Bioactive Compounds: Synthesis, Extraction, and Applications

Khan,

Akhlaq,

Rasool

et al. 2024

Pharmaceutical and Nutraceutical Potential of Cyanobacteria

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Potential avenue of genetic engineered algal derived bioactive compounds: influencing parameters, challenges and future prospects

Cited by 4 publications

References 165 publications

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

Network pharmacology‒based analysis of marine cyanobacteria derived bioactive compounds for application to Alzheimer’s disease

Phytohormones and Pheromones in the Phycology Literature: Benchmarking of Data-Set and Developing Critical Tools of Biotechnological Implications for Commercial Aquaculture Industry

Cyanobacterial Bioactive Compounds: Synthesis, Extraction, and Applications

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