Potential Benefits of Oral Cryotherapy for Chemotherapy-Induced Mucositis

Wodzinski, Amelia

doi:10.1188/16.cjon.462-465

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…The incidence of oral mucositis was also lower in patients undergoing cryotherapy with ice made from chamomile infusion [23]. Although the effects of cryotherapy on prevention, reduction of injury time, and severity of oral mucositis have been previously described [43,44], the association of chamomile improved the results of conventional cryotherapy. Chamomile gel was also effective in relieving pain in patients with traumatic ulcers [21].…”

Section: Cg-control Pg-placebomentioning

confidence: 93%

Plant extracts used in Brazil for treatment of oral ulcers and mucositis: systematic review

VOLPATO,

EUBANK,

LARA

et al. 2024

Braz. Dent. Sci.

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Objective: To identify and analyze plant extracts used in Brazil for the treatment of oral ulcers and oral mucositis. Material and Methods: A systematic review was registered in PROSPERO (CRD 42018102184) and performed following the PRISMA protocol. The databases searched were PubMed, Web of Science, Scopus, Lilacs, Scielo, the Brazilian Dentistry Library. Manual searches were also performed. Results: Initially, 440 studies were found, of which 392 were excluded after reading the titles and abstracts. A total of 29 articles were read in full and 11 studies were excluded, resulting in 18 articles included in the systematic review. Nine plant species were identified in five clinical trials and 13 in vivo studies, with Chamomila recutita being the most used (33.3% of the studies). Chamomila recutita showed more promising results for analgesic, anti-inflammatory, and healing properties. Calotropis procera latex significantly decreased (p<0.05) inflammatory mediators, such as TNF-α and IL-1β in oral mucositis induced in rats. Eupatorium laevigatum showed anti-inflammatory activity and analgesic action on oral ulcers. Carapa guianensis Aubl. reduced the severity and painful symptoms of oral mucositis and exhibited better results compared to the use of low power laser. Curcuma longa L accelerated re-epithelialization and resolution of inflammatory processes. Spondias mombin reduced oxidative stress and inflammation caused by oral mucositis and helped on healing it. Extracts of Aloe barbadensis Miller or Aloe vera showed antiinflammatory action but did not help in the healing process of oral ulcers. Copaifera reticulata Ducke oil did not induce improvement in the healing process, nor did it show an anti-inflammatory effect. Malva sylvestris did not show an anti-inflammatory action on oral lesions in humans or rats. The assessment of methodological heterogeneity showed the impossibility of performing a meta-analysis. Risk of bias varied from low to high. Conclusion:The plant species most used and with the best results for the treatment of oral ulcerations and oral mucositis was Chamomilla recutita. Spondias mombin L., Curcuma longa L., Carapa guianensis Aubl and Calotropis procera showed good results in the treatment of oral mucositis, while Eupatorium laevigatum was efficient in the treatment of ulcers of traumatic origin. Malva sylvestris, Copaifera reticulata Ducke, and Aloe barbadensis Miller did not exhibit significant results.

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Section: Cg-control Pg-placebomentioning

confidence: 93%

Plant extracts used in Brazil for treatment of oral ulcers and mucositis: systematic review

VOLPATO,

EUBANK,

LARA

et al. 2024

Braz. Dent. Sci.

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“…5-fluorouracil mempunyai waktu paruh yang sangat pendek yaitu 5-20 menit. 16 Cryotherapy dapat bekerja pada daerah sekitar rongga mulut dimana rongga mulut mengalami vasokonstriksi akibat mengulum es batu (chip), hal ini menyebabkan obat kemoterapi khususnya 5-fluorouracil kombinasi dengan obat yang lain dapat mengurangi atau memperlambat aliran darah sehingga efek sitotoksik pada daerah rongga mulut dapat diminimalisir .7 Kemoterapi 5-fluorouracil dapat merusak lapisan pada sel epitel basal secara langsung, menyebabkan aktifnya Reaktif Oksigen Spesies (ROS). Kerusakan sel menyebabkan timbulnya peningkatan reaksi radang.…”

Section: Pembahasanunclassified

“…Kerusakan sel menyebabkan timbulnya peningkatan reaksi radang. 16 hal ini dapat mengaktifkan Nuclear Faktor Kappa B (NFkB). TNF-ƛ yang aktif secara langsung akan mengaktifkan NFkB, Mitogen-Activated Protein Kinase (MAPK) dan sphyngomyelinase patways.…”

Section: Pembahasanunclassified

Hubungan Cryotherapy terhadap Mukositis Oral pada Pasien Kanker Payudara dengan Kemoterapi di Ruangan Kemoterapi Rumah Sakit M. Djamil Padang

Ajani¹,

Malini²,

Fatmadona³

2020

JKA

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Mukositis oral merupakan salah satu efek samping yang paling sering muncul pada pasien kanker yang menjalani kemoterapi. Mukositis oral dapat mengakibatkan terjadi gangguan fungsi integritas rongga mulut sehingga menimbulkan rasa nyeri hebat yang dapat mengakibatkan penundaan pengobatan kemoterapi untuk siklus berikutnya. Mukositis oral juga dapat mengurangi dosis pada kemoterapi yang akan dijalani oleh pasien sehingga pengobatan kanker tidak bisa optimal di lakukan. Tujuan: Menentukan hubungan cryotherapy terhadap mukositis oral pada pasien kanker payudara dengan kemoterapi. Metode: Penelitian ini merupakan survei analitik dengan pendekatan cross sectional. Teknik pengambilan sampel pada penelitian ini adalah consecutive sampling. Ada 32 orang responden yang menjadi sampel, terdiri dari dua kelompok. Intervensi pada penelitian ini yaitu cryotherapy. Cryotherapy diberikan sewaktu kemoterapi dilaksanakan sampai dengan 14 hari setelah kemoterapi dengan durasi 20 menit sekali sehari. Penilaian mukositis oral dengan menggunakan lembaran observasi OAG (Oral Assesment Guide). Penilaian OAG di lakukan sebelum cryotherapy dan hari ke-14 setelah kemoterapi. Hasil: Ada hubungan cryotherapy dengan penurunan skala mukositis oral pada pasien kanker payudara (p value 0,013). Cryotherapy dapat menyebabkan terjadinya vasokonstriksi pada daerah rongga mulut, mengurangi aliran darah yang membawa obat kemoterapi mencapai area mukosa mulut lebih sedikit. Simpulan: Cryotherapy mampu menurunkan skala mukositis oral pada pasien kanker payudara dengan kemoterapi kombinasi 5-fluorouracil.

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“…OC is a normally well-tolerated intervention, with headache, tooth sensitivity, and numbness of the mouth being the most common side effects. In addition, it is the most accessible and efficient technique of all the proposals [15,16].…”

Section: Introductionmentioning

confidence: 99%

Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy

González

García-Quintanilla

Guerrero-Agenjo

et al. 2021

IJERPH

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Oral mucositis (OM) is a common side effect of cancer therapies. It causes ulcerative, painful lesions in the oral cavity that can provoke malnutrition, increased risk of infection, longer hospital stays, and seriously affect the quality of life. Cooling the mucosa with oral cryotherapy (OC) during and/or after chemotherapy is the most accessible and tolerable intervention available. The aim of this study is to define the efficacy of OC for preventing OM induced by chemotherapy/radiotherapy in adult patients with cancer. Secondary endpoints include associated problems as pain. A systematic search was performed using the Pubmed, WOS (Web of Science), Cochrane Library, CINAHL, and BVS databases for articles published up to 2010. After inclusion and exclusion criteria were applied, a total of eight articles were analyzed in this review. In seven of the eight articles, the incidence of OM of all grades was significantly lower in the OC group compared with the no-OC group. Use of opioids and level of pain were also significantly reduced. OC is an effective intervention to reduce the incidence of OM induced by chemotherapy as well as the associated severity and pain. Based on these results, OC with only water or with chamomile, associated or not with other mouthwash therapies, is an effective intervention to reduce the incidence of OM induced by chemotherapy as well as the associated severity and pain.

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Potential Benefits of Oral Cryotherapy for Chemotherapy-Induced Mucositis

Cited by 7 publications

References 16 publications

Plant extracts used in Brazil for treatment of oral ulcers and mucositis: systematic review

Plant extracts used in Brazil for treatment of oral ulcers and mucositis: systematic review

Hubungan Cryotherapy terhadap Mukositis Oral pada Pasien Kanker Payudara dengan Kemoterapi di Ruangan Kemoterapi Rumah Sakit M. Djamil Padang

Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy

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