Potential benefits of phytochemicals from Azadirachta indica against neurological disorders

Sandhir, Rajat; Khurana, Mehak; Singhal, Nitin

doi:10.1016/j.neuint.2021.105023

Cited by 26 publications

(11 citation statements)

References 148 publications

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“…As the literature suggests, the aqueous extracts of A. indica leaves exhibit anti-inflammatory (Modi et al, 2021), hepatoprotective (Sani et al, 2020), antibacterial (Hikaambo et al, 2022), wound healing (Ugoeze et al, 2021), Antidiabetic (Dholi et al, 2011;Hikaambo et al, 2022), etc. Further, the organic extracts of neem leaves have been reported to show anticancer (Kashif et al, 2019), virucidal activity (Baildya et al, 2021), antimalarial activity (Udeinya et al, 2008;Akin-Osanaiya et al, 2013;Afolabi et al, 2021) and neuroprotective effects (Sandhir et al, 2021). It has always been challenging to control the initial release of hydrophilic molecules from delivery systems.…”

Section: Resultsmentioning

confidence: 99%

Development of polymeric nanofibers blended with extract of neem (Azadirachta indica), for potential biomedical applications

et al. 2022

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In recent years, electrospinning has emerged as a promising technique for the preparation of nanofibers with unique properties like flexibility, high porosity and high surface area. In the context of nanodelivery systems, polymer-based nanofibers have become promising carriers of drugs and bioactive compounds ensuring their sustained release and targeted delivery. In this study, neem extract-loaded nanofibers were developed as sustained delivery systems using the electrospinning method. The chitosan, alginate and polyethylene oxide were used as the polymeric matrix for loading of aqueous extract of neem leaves. The prepared nanofibers NF1, NF2 and NF3 carrying 2%, 4% and 6% extract respectively were characterized using SEM, FTIR, XRD and TGA. Further, the as-prepared nanocomposites exhibited a high degree of swelling and dual-phase release of phytoconstituents. Moreover, the developed controlled delivery systems were tested for antifungal and antioxidant potential. Importantly, the bioactivities of the prepared nanofibers could be improved further by using organic extracts which are generally enriched with phytoconstituents. Herein, we selected biodegradable and mucoadhesive biopolymers and an aqueous extract of neem for the development of controlled-delivery nanofibers by electrospinning through a sustainable and cleaner production process. Thus, the prepared biocompatible nanofibrous systems with biphasic release profile could be employed for biomedical applications including wound dressing, soft tissue scaffolds and as transdermal carriers.

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Section: Resultsmentioning

confidence: 99%

Development of polymeric nanofibers blended with extract of neem (Azadirachta indica), for potential biomedical applications

et al. 2022

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“…In the context of cancer control, azadirachtin activates certain pro-apoptotic factors, while inhibiting anti-apoptotic factors that are crucial for cancer management. This results in a reduction in the Bcl-2/Bax ratio and an Azapirone Seeds,bark Anti-malarial, insecticide [27][28] Nimbin Seeds, leaves Anti-fungal [29] Salannin Seeds Ant-ifeedant, anti-fungal [30] meliantriol Seeds Anti-feedant, insecticide [26] Nimbolide Leaves Anti-cancer, insecticide [26] Nimbidin Seeds Anti-inflammatory [31] Nimbiol Seeds, leaves Anti-viral [32] Nimbocinol Seeds, leaves Anti-viral [32] Nimbidol Seeds, leaves Anti-inflammatory [33] Nimbandiol Leaves Anti-viral [34] Nimbinin Seeds Anti-viral [35] Nimolinone Seeds, leaves Anti-tumor [36] 17-Hydroxyazadiradione Leaves Anti-viral, anti-malarial, anti-fungal [34,37] 7-Desacetyl-7-benzoylazadiradione Leaves Anti-diabetic [38] 7-Deacetyl-7-benzoylgedunin Leaves Antiviral [38] Gedunin Seeds, bark Anti-malarial [39] Sterol β-sitosterol Seeds, flowers Anti-hypertensive, anti-cancer [40] Stigmasterol Leaves Anti-hypertensive, anti-cancer [41] Coumarin 7-hydroxy-6-methoxycoumarin All Anti-bacterial [42] Tannin Glycerite Bark Anti-inflammatory [43] Sulfide Propyl, propyl trisulfide Seeds, leaves Insecticidal, repellent, [44] Polysaccharide Polysaccharide GI Bark Anti-cancer [45] Polysaccharide GII, III Anti-allergic [45] Flavone Prenylated flavanone Flowers Anti-mutation [46] Isoprenylated flavanone Leaves Hypotensive [47] Quercetin Flowers, Leaves Lipid-lowering, hypotensive [41] Kaempferol Leaves Lipid-lowering, hypotensive [41] Aliphatic acids Nonacosane Leaves Anti-filtering pathogens [48] elevated expression of Apaf-1 and caspase-3, culminating in the downregulation of proliferating cell nuclear antigens. Consequently, this leads to cell fragmentation, condensation, and ultimately, tumor cell apoptosis.…”

Section: Biological Activity and Mechanism Of Actionmentioning

confidence: 99%

A comprehensive review of azadirachtin: physicochemical properties, bioactivities, production, and biosynthesis

Su,

Liang,

Xue

et al. 2023

Acupuncture and Herbal Medicine

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Azadirachtin, a complex tetratriterpenoid limonin with potent insecticidal properties, is the most widely used biological pesticide worldwide. Its versatile pharmacological applications include the inhibition of tumor growth and anti-malarial, anti-bacterial, and anti-inflammatory properties. Azadirachtin plays a pivotal role in pest control and novel drug development. The primary source of azadirachtin is the neem tree (Azadirachta indica A. Juss), with an azadirachtin content ranging from 0.3% to 0.5%. Despite the market demand for botanical pesticides reaching approximately 100,000 tons per year, the annual neem production in China is only 1.14 tons. Although azadirachtin can be obtained through plant extraction or chemical synthesis, the quantity obtained does not meet the market demand in China. The sluggish pace of azadirachtin biosynthesis results from the limited availability of genetic information and the complexity of the synthetic pathway. Recent advancements in azadirachtin biosynthesis hold promise as an efficient collection method. In this study, we explored the physicochemical properties, biological activities, mechanisms of action, and acquisition methods of azadirachtin. We also delved into recent progress in azadirachtin biosynthesis and assessed potential future usage challenges. This study aims to establish a theoretical foundation for the scientific application and efficient synthesis of azadirachtin, offering valuable reference information to the industry.

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“…2 Their diverse structures contribute to the broad spectrum of biological activities associated with limonoids, including antitumor, anti-inflammatory, antibacterial, antiviral, and insecticidal properties as well as metabolic regulation. [3][4][5][6][7][8] The complexity of limonoid structures presents challenges in both chemical and biosynthetic syntheses. Consequently, limonoids have become a focal point of interest for chemists and pharmacologists.…”

Section: Introductionmentioning

confidence: 99%

Swieteliacates S–U, phragmalin limonoids, from the leaves of Swietenia macrophylla

Sun,

Xie,

Jin

et al. 2024

Org. Biomol. Chem.

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Potential benefits of phytochemicals from Azadirachta indica against neurological disorders

Cited by 26 publications

References 148 publications

Development of polymeric nanofibers blended with extract of neem (Azadirachta indica), for potential biomedical applications

Development of polymeric nanofibers blended with extract of neem (Azadirachta indica), for potential biomedical applications

A comprehensive review of azadirachtin: physicochemical properties, bioactivities, production, and biosynthesis

Swieteliacates S–U, phragmalin limonoids, from the leaves of Swietenia macrophylla

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