Potential biomarker of coal workers' pneumoconiosis

Kim, K.-A.; Lim, Young Wook; Kim, J.-H.; Kim, E.-K.; Chang, Hwang-Shin; Park, Y.-M.; Ahn, Byoung Yong

doi:10.1016/s0378-4274(99)00101-0

Cited by 24 publications

(14 citation statements)

References 8 publications

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“…Latest in vitro release researches have indicated that proinflammatory cytokine levels of TNF-alpha and IL1 were triggered in CWP (Schins and Borm, 1995;Zhai et al, 1998;Kim et al, 1999). According to our data, we found an enhanced release of TNF-alpha from blood monocytes after coal dust and LPS stimulation in contrast to spontaneous release in both controls and patients.…”

Section: Discussionsupporting

confidence: 68%

A Genotyping and Phenotyping Study Concerning the Possible Effects of Some Inflammatory Cytokine Gene Polymorphisms on the Development of Coal Workers' Pneumoconiosis

Ateş¹

2017

SOJI

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Section: Discussionsupporting

confidence: 68%

A Genotyping and Phenotyping Study Concerning the Possible Effects of Some Inflammatory Cytokine Gene Polymorphisms on the Development of Coal Workers' Pneumoconiosis

Ateş¹

2017

SOJI

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“…Studies on the release of monocyte TNF-α after in vitro stimulation with coal dusts showed that TNF-α was increased in miners, especially in the early stages of pneumoconiosis. Miners who showed an abnormally high dust-stimulated release of TNF-α had an increased risk of progression to fibrosis (Kim et al, 1999;Schins & Borm, 1995). It was hypothesized that subjects carrying common functional polymorphisms IRON AND CALCIUM IN LUNG DISEASE 53 in these inflammatory cytokines, chemokines, growth factors, and antioxidant enzymes may be more susceptible to coal dust-induced CWP development (details recently reviewed) (Yucesoy & Luster, 2007).…”

Section: Oxidants Cytokines and Growth Factors In Cwpmentioning

confidence: 99%

Understanding the Chemical Properties of Macerals and Minerals in Coal and its Potential Application for Occupational Lung Disease Prevention

Huang

Finkelman

2008

Journal of Toxicology and Environmental Health, Part B

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Recent increases in oil price further strengthen the argument that coal and coal products will play an increasingly important role in fulfilling the energy needs of our society. Coal is an aggregate of heterogeneous substances composed of organic (macerals) and inorganic (minerals) materials. The objective of this review was to assess whether some chemical parameters in coal play a role in producing environmental health problems. Basic properties of coal--such as chemical forms of the organic materials, structure, compositions of minerals--vary from one coal mine region to another as well as from coals of different ranks. Most importantly, changes in chemical properties of coals due to exposure to air and humidity after mining--a dynamic process--significantly affect toxicity attributed to coal and environmental fate. Although coal is an extremely complex and heterogeneous material, the fundamental properties of coal responsible for environmental and adverse health problems are probably related to the same inducing components of coal. For instance, oxidation of pyrite (FeS2) in the coal forms iron sulfate and sulfuric acid, which produces occupational lung diseases (e.g., pneumoconiosis) and other environmental problems (e.g., acid mine drainage and acid rain). Calcite (CaCO3) contained in certain coals alters the end products of pyrite oxidation, which may make these coals less toxic to human inhalation and less hazardous to environmental pollution. Finally, knowledge gained on understanding of the chemical properties of coals is illustrated to apply for prediction of toxicity due to coal possibly before large-scale mining and prevention of occupational lung disease during mining.

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“…1,2 However, the underlying pathophysiological mechanism for CWP is not completely understood. [3][4][5] Coal dust particles are known to stimulate macrophages. The activated macrophages produce excessive amounts of reactive oxygen species (ROS), and cytokines that play key roles in the pathogenesis of pneumoconiosis.…”

Section: Introductionmentioning

confidence: 99%

Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

et al. 2008

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Coal workers’ pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP is divided into two stages depending on the extent of the disease, as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). In the present study, serum and bronchoalveolar lavage (BAL) cytokine (interleukin-1β [IL-1β], IL-6, tumor necrosis factor-α [TNF-α], transforming growth factor-β [TGF-β]) and antioxidant enzymes levels, their relation with the disease severity, and whether they can be considered as biological markers were investigated. Serum and BAL levels of IL-1β, IL-6, and TNF-α were higher in SP and PMF patient groups compared with that in active and retired miner groups. Serum and BAL IL-1β, IL-6, and TNF-α levels were also found to be higher in patients with PMF compared with the SP group. BAL superoxide dismutase (SOD), glutathione peroxidase, and catalase levels and serum SOD level were increased in both patient groups compared with the control group. In addition, mean serum and BAL TGF-β levels were found to be increased in patients with SP compared with PMF group. Based on these results, BAL and serum cytokine and antioxidant enzymes levels were evaluated and discussed as potential biomarkers for different stages of CWP.

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Potential biomarker of coal workers' pneumoconiosis

Cited by 24 publications

References 8 publications

A Genotyping and Phenotyping Study Concerning the Possible Effects of Some Inflammatory Cytokine Gene Polymorphisms on the Development of Coal Workers' Pneumoconiosis

A Genotyping and Phenotyping Study Concerning the Possible Effects of Some Inflammatory Cytokine Gene Polymorphisms on the Development of Coal Workers' Pneumoconiosis

Understanding the Chemical Properties of Macerals and Minerals in Coal and its Potential Application for Occupational Lung Disease Prevention

Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

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