Potential Chemoprevention of 7,12-Dimethylbenz[a]anthracene Induced Renal Carcinogenesis by Moringa oleifera Pods and Its Isolated Saponin

Sharma, Veena; Paliwal, Ritu

doi:10.1007/s12291-013-0335-y

Cited by 17 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and its isolated saponin (50 mg/kg body weight; p.o.) can attenuate 7,12-dimethylbenz[a]anthracene (DMBA)-induced renal carcinogenesis in mice through effectively suppressing renal oxidative stress and toxicity [ 70 ].…”

Section: Anticancer Property Of M Oleiferamentioning

confidence: 99%

Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

et al. 2018

View full text Add to dashboard Cite

Moringa oleifera Lam. (M. oleifera), which belongs to the Moringaceae family, is a perennial deciduous tropical tree, and native to the south of the Himalayan Mountains in northern India. M. oleifera is rich in proteins, vitamin A, minerals, essential amino acids, antioxidants, and flavonoids, as well as isothiocyanates. The extracts from M. oleifera exhibit multiple nutraceutical or pharmacological functions including anti-inflammatory, antioxidant, anti-cancer, hepatoprotective, neuroprotective, hypoglycemic, and blood lipid-reducing functions. The beneficial functions of M. oleifera are strongly associated with its phytochemicals such as flavonoids or isothiocyanates with bioactivity. In this review, we summarize the research progress related to the bioactivity and pharmacological mechanisms of M. oleifera in the prevention and treatment of a series of chronic diseases—including inflammatory diseases, neuro-dysfunctional diseases, diabetes, and cancers—which will provide a reference for its potential application in the prevention and treatment of chronic diseases or health promotion.

show abstract

Section: Anticancer Property Of M Oleiferamentioning

confidence: 99%

Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Moringa oleifera has been reported to have antipyretic, anti-inflammatory, anti-ulcer, antioxidant, renal and hepatoprotective activities amongst others. 36 An in vivo animal study on the antioxidant potential of Moringa oleifera pods and its isolated saponin was conducted in mice treated with renal carcinogens and with the hydroethanolic extract of the herb (200 and 400mg/kg body weight).…”

Section: The Immunological Activity Of Emblica Officinalismentioning

confidence: 99%

“…The results showed significant (p<0.001) suppressed renal oxidative stress and toxicity in the treatment group when compared to the control group. 36 A study on the anti-inflammatory effects of the aqueous extract of the root of Moringa oleifera was conducted on rats using indomethacin (10mg/kg) as the standard drug. Inhibition in the development of oedema was observed in the Moringa oleifera treatment group (dose of 750mg/kg).…”

Section: The Immunological Activity Of Emblica Officinalismentioning

confidence: 99%

The Immunomodulatory, Nitric Oxide and Cytokine activity of SeptilinTM

Hoosen

2019

Bangladesh J Med Sci

View full text Add to dashboard Cite

Objective: Herbal immunomodulatory preparations are increasing in popularity. In vitro, in vivo and clinical trial studies are needed to ensure safety, quality and efficacy of these herbal medicines. SeptilinTM, a proprietary herbal medicinal product has been reported to have immunomodulatory effects. Methods: For this narrative review the author surveyed the primary literature on SeptilinTM and its ingredients with regards to immunomodulatory, nitric oxide (NO) and cytokine activity. Databases utilized included Pubmed, Science Direct and EBSCO, Google Scholar as well as a hand search through journals and bibliographies was included. English language restriction was observed. The following parameters had to be met for study inclusion: investigations on SeptilinTM as a formulation (liquid or dried form) were accepted. Research on the isolated constituents of SeptilinTM (single herbs) was also accepted. The accepted model types included; in vitro and in vivo, animal and human models. The following were also required; method of preparation of the SeptilinTM, concentration of the plant preparation and dose/exposure time. Only studies providing statistically significant results with regards to immunomodulatory, cytokine and nitric oxide activity were included. Results: SeptilinTM and its ingredients had effects on at least one cytokine. The most frequently studied cytokines were IL-1, IL-2, IL-4, IL-6, TNF, and IFN. Many studies also reported on NO activities. SeptilinTM and its ingredients demonstrated modulation of several cytokines with varying results on NO activity. The bulk of studies conducted on SeptilinTM and its ingredients were in vitro, the few in vivo studies were mainly conducted in rats or mice models with a few studies conducted on humans. Conclusion: The in vitro and in vivo research demonstrates that SeptilinTM and its ingredients modulate the secretion of multiple cytokines and NO with varying effects on cytokine and NO secretion due to divergent research methodologies. The reported therapeutic success of these herbal products by natural medicine practitioners and clinicians may be due to their effects on cytokine and NO activity. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.675-688

show abstract

“…For a potent chemopreventive agent, the presence of phytochemicals having strong antioxidant property which can quence reactive oxygen species, chelate metal ions and generate membrane bound antioxidants is necessary 27 . The antitumor property can be attributed to the presence of antioxidant properties and also to the phytochemical betulinic acid present in the fruit of D.indica.…”

Section: Fig 5: Cumulative Number Of Papillomas Of the Four Groups (Imentioning

confidence: 99%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

Dillenia indica linn fruit, commonly known as elephant apple has indigenous use in various culinary dishes of Assam and it has a history of being used as traditional medicine. The present study was undertaken to evaluate its antioxidant and chemopreventive properties. Ethanolic extract of Dillenia indica fruit was used as experimental sample. Antioxidant activity was studied in vitro, at concentrations (20µg/ml, 40µg/ml ,60µg/ml, 80µg/ml, 100µg/ml) where it showed significant (p<0.05) inhibition of free radicals formation, hydroxyl radical and nitric oxide scavenging property and also reducing ability when compared with a standard antioxidant, ascorbic acid. Chemopreventive potential was evaluated in 8-10 weeks old swiss albino mice by giving a single tropical application of initiator-7,12-dimethylbenza(α)anthracene (DMBA) at a concentration of 100µg/100µl acetone and promotion after 14 days by repeated application of croton oil (1% in acetone) thrice a week for 15 weeks. Oral application of D.indica at dose of 250 mg/kg body weight of mice selected after acute oral toxicity test, showed significant (p<0.05) reduction in DMBA induced mice skin papillomagenesis in (i) post-initiation group (oral dose given on the day of promotion) and (ii) pre+post initiation group (oral dose given 7 days before initiation and continued till the end of experiment). There was reduction in the total papilloma count, tumor yield, tumor burden and tumor incidence when compared with carcinogen control group. Inhibition of tumor formation upto 88.3% was found after 15 weeks of treatment which clearly shows the antitumor property of Dillenia indica fruit.

show abstract

Potential Chemoprevention of 7,12-Dimethylbenz[a]anthracene Induced Renal Carcinogenesis by Moringa oleifera Pods and Its Isolated Saponin

Cited by 17 publications

References 29 publications

Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

The Immunomodulatory, Nitric Oxide and Cytokine activity of SeptilinTM

Untitled

Contact Info

Product

Resources

About