Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark

Singh, Brahma N.; Singh, Braj Raj; Sarma, B. K.; Singh, Hardeep

doi:10.1016/j.cbi.2009.05.007

Cited by 147 publications

(121 citation statements)

References 40 publications

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“…It is known to all that the activity of ALT, AST, ALP, GGT and TBL are representative of liver function and their increased levels are sensitive indicators of hepatic injury (Singh et al, 2009). Generally, liver damage induced by DEN is related to the disruption of liver cell metabolism and membrane instability and subsequently causes distinctive changes in the activities of serum enzyme.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Zhao¹,

Peng²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model. One hundred and twenty male SD rats used in this study were divided into six groups. Those receiving DEN with curcumin (CUR) or HZC were studied compared with the DEN-alone group. The study demonstrated that DEN induced severe histological and immunohistochemical changes in liver tissues, significantly increasing the levels of liver marker enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and total bilirubin level (TBL)). The hepatocarcinoma incidences were 100.0%, 36.7% and 20.0% in the DEN-alone, DEN-CUR and DEN-HZC groups, respectively. Although macroscopic and microscopic features suggested that both CUR and HZC were effective in inhibiting DENinduced hepatocarcinogenesis, HZC was exerted a stronger influence. Immunohistochemical analysis with PCNA demonstrated significantly differences among the groups (all P < 0.05). Taken together, the results suggested application of CUR and HZC could prevent the occurrence of carcinogenesis and HZC may be a more potent compound for prevention of DEN-induced hepatocarcinogenesis in rats than CUR.

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Section: Discussionmentioning

confidence: 99%

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Zhao¹,

Peng²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Plant antioxidant defense systems including enzymatic and non-enzymatic protection have co-evolved with aerobic metabolism to counteract oxidative damage due to ROS. Protective enzymes in-822 R. Davar et al (Asada 2000) Superoxide dismutase Catalyzing the removal of superoxide radical (Chen et al 2010) Guaiacol peroxidase Catalyzing H 2 O 2 in the cytosol, vacuole, and cell wall as well as in extracellular space (Jebara et al 2005) clude catalase (CAT), ascorbate peroxidase (APX), guaiacol peroxidase (GPX), and superoxide dismutase (SOD) ( Table 1), while several molecules, such as glutathione, proline, ascorbate, and carotenoids provide non-enzymatic protection (Jung et al 2000;Lombardi & Sebastiani 2005;Singh et al 2009). Previous studies have shown that alteration in the expression/activity of ROS-scavenging enzymes could also be a key step in the activation of plant defence against phytopathogens.…”

Section: Introductionmentioning

confidence: 99%

Changes in antioxidant systems in sunflower partial resistant and susceptible lines as affected by Sclerotinia sclerotiorum

Davar

Darvishzadeh

Majd³

2013

Biologia

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Sunflower, Helianthus annuus L., is a major oil-seed crop widely cultivated throughout the globe. White mold, caused by necrotrophic pathogen Sclerotinia sclerotiorum (Lib.) de Bary, is a common and widespread disease of sunflower. Changes in various physiological activities such as production of malondialdehyde (MDA) as the main end product of lipid peroxidation, enzymatic and non-enzymatic activities and proline content, were investigated in leaves and stems of sunflower lines either resistant or susceptible to S. sclerotiorum. The results showed accumulation of high amount of free proline in the leaves of the resistant line. S. sclerotiorum invasion resulted in increase in the MDA content in both lines compared to the controls. Superoxide dismutase, ascorbate peroxidase and guaiacol peroxidase activities significantly increased in the stem and leaves of inoculated lines. In the resistant line, Sclerotinia infection significantly induced catalase (CAT) activity both in the stem and leaves of contaminated plants. The activity of CAT was significantly decreased in susceptible line. Based on our results the activity of antioxidant enzymes was much pronounced in sunflower resistant line than in susceptible one. Studied lines showed distinctive activity considering different biochemical parameters, which may point to further directions in exploring host-pathogen interaction and lead to selection and production of new lines to achieve an improvement of plant adaptation to pathogen.

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“…It contains a summary of a multiplicity of bioactive components [12]; plant bark is used widely for bronchitis , colds, diarrhea , leukoderma and bleeding piles [13]. Tender leaves and pods are given to treat diarrhea and are also well thought-out in folk medicine to heal diabetes mellitus [14].…”

Section: ‫الخالصـة‬mentioning

confidence: 99%

Antimicrobial Effect of Acacia Nilotica on Some Gram Positive and Gram Negative Bacteria

Hameed

2018

MJS

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Acacia nilotica is a plant has an inspiring range of medicinal uses. This plant contributes a number of groups among which are alkaloids, volatile essential oils, phenols and phenolic glycosides, resins, oleosins, steroids, tannins and terpenes, this study aims to: examine the antimicrobial action of ethanolic extraction from fruits and seeds of Acacia nilotica. Hot ethanol extract (48°C) of fruits and seeds obtained from Acacia nilotica, used in minimum bactericidal concentration (MBC), agar diffusion method to detect the antibacterial effect of the extract. Elucidate almost for all bacterial types used in this study, the concentration of 100mg/ml was the mostly effective concentration on bacteria (Staphylococcus aureus, Streptococcus pneumonia, and Proteus mirabilis); while the E. coli and Pseudomonas aeruginosa the concentration of 75 mg/ml was the effective concentration for both of them as an optimum concentration.

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Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark

Cited by 147 publications

References 40 publications

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Preventive Effect of Hydrazinocurcumin on Carcinogenesis of Diethylnitrosamine-induced Hepatocarcinoma in Male SD Rats

Changes in antioxidant systems in sunflower partial resistant and susceptible lines as affected by Sclerotinia sclerotiorum

Antimicrobial Effect of Acacia Nilotica on Some Gram Positive and Gram Negative Bacteria

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