Potential compound of<i>Curcuma xanthorrhiza</i>and<i>Curcuma zedoaria</i>as Mortalin inhibitor to control cancer cell growth through computational study

Fitriana, Nur; Rifa’i, Muhaimin; Widodo, Widodo

doi:10.1088/1755-1315/391/1/012032

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2024

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Cited by 2 publications

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Anti-cancer potential of white turmeric extract (Curcuma zedoaria) in MCF-7 and HEPG-2 cancer cells

Rahayu,

Ma’arif,

Afifah

et al. 2024

Proceedings of the 2nd International Interdisciplinary Scientific Conference “Digitalization and Sustainability for Development

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Anti-cancer potential of white turmeric extract (Curcuma zedoaria) in MCF-7 and HEPG-2 cancer cells

Rahayu,

Ma’arif,

Afifah

et al. 2024

Proceedings of the 2nd International Interdisciplinary Scientific Conference “Digitalization and Sustainability for Development

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Synthetic and Natural Inhibitors of Mortalin for Cancer Therapy

Kaushal,

Gupta,

Shefrin

et al. 2024

Cancers

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Upregulation of stress chaperone Mortalin has been closely linked to the malignant transformation of cells, tumorigenesis, the progression of tumors to highly aggressive stages, metastasis, drug resistance, and relapse. Various in vitro and in vivo assays have provided evidence of the critical role of Mortalin upregulation in promoting cancer cell characteristics, including proliferation, migration, invasion, and the inhibition of apoptosis, a consistent feature of most cancers. Given its critical role in several steps in oncogenesis and multi-modes of action, Mortalin presents a promising target for cancer therapy. Consequently, Mortalin inhibitors are emerging as potential anti-cancer drugs. In this review, we discuss various inhibitors of Mortalin (peptides, small RNAs, natural and synthetic compounds, and antibodies), elucidating their anti-cancer potentials.

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Potential compound ofCurcuma xanthorrhizaandCurcuma zedoariaas Mortalin inhibitor to control cancer cell growth through computational study

Cited by 2 publications

References 14 publications

Anti-cancer potential of white turmeric extract (Curcuma zedoaria) in MCF-7 and HEPG-2 cancer cells

Anti-cancer potential of white turmeric extract (Curcuma zedoaria) in MCF-7 and HEPG-2 cancer cells

Synthetic and Natural Inhibitors of Mortalin for Cancer Therapy

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