2011
DOI: 10.1038/hr.2011.113
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Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders

Abstract: The renin-angiotensin system and Wnt/frizzled receptor signaling pathways are important in the development of essential organs, and their aberrant activation results in cardiovascular and renal pathologies. The (pro)renin receptor ((P)RR)-bound (pro)renin is enzymatically active generating angiotensin-II and activating mitogen-activated protein kinases, leading to cell proliferation and to upregulation of profibrotic genes expression, resulting in end-organ damage. The (P)RR does more than bind to (pro)renin, … Show more

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Cited by 25 publications
(12 citation statements)
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References 137 publications
(251 reference statements)
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“…We also could not confirm the predictive value of increased s(P)RR concentration before delivery (in early, middle, and late pregnancy) for preeclampsia in this study. However, as (P)RR contributes to renal disorders, 25 s(P)RR might be associated with proteinuria in preeclampsia pathogenesis, given that high levels of s(P)RR at delivery were associated with the incidence of preeclampsia but not BP late in pregnancy. Future studies are needed to clarify the causal relationship between elevated s(P)RR levels and the pathophysiology of preeclampsia.…”
Section: Discussionmentioning
confidence: 99%
“…We also could not confirm the predictive value of increased s(P)RR concentration before delivery (in early, middle, and late pregnancy) for preeclampsia in this study. However, as (P)RR contributes to renal disorders, 25 s(P)RR might be associated with proteinuria in preeclampsia pathogenesis, given that high levels of s(P)RR at delivery were associated with the incidence of preeclampsia but not BP late in pregnancy. Future studies are needed to clarify the causal relationship between elevated s(P)RR levels and the pathophysiology of preeclampsia.…”
Section: Discussionmentioning
confidence: 99%
“…WNT3 belongs to the Wnt/frizzled receptor signaling pathway, which has been suggested to have an important functional role in cardiovascular and renal disorders. 40…”
Section: Application To the Bp Gwas Data From The Continental Originsmentioning
confidence: 99%
“…The pro-proliferative effect of the prorenin-(P)RR-PLZF axis was previously demonstrated by our group (24) whereas the constitutive functions of the (P)RR were analysed in the present study. MAPKs (78), the Wnt pathway (79) and V-ATPases (80) are known to mediate proliferation in general and likely contribute to pro-survival/pro-proliferative effects of the (P)RR (21,51,81,82). In addition, the phosphatase PRL-1 may be involved in the regulation of proliferation downstream of the (P)RR (1).…”
Section: Figurementioning
confidence: 99%